Green spectrophotometric methods for the determination of a binary mixture of lidocaine hydrochloride and cetylpyridinium chloride in the presence of dimethylaniline

Merey, Hanan A.; Ramadan, Nesrin K.; Diab, Sherine S.; Moustafa, Azza A.

doi:10.1016/j.saa.2020.118743

Cited by 17 publications

(10 citation statements)

References 41 publications

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“…The results were very reliable with those obtained through the application of the reported methods. 31,34 According to the results of statistical tests such as the analysis of variance (ANOVA), F -test, and Student’s t -test, there was not a substantial variation in the analytical efficiency in terms of accuracy and precision and, respectively, as shown in Supplementary Tables 3S and 4S.…”

Section: Resultsmentioning

confidence: 99%

A sustainable data processing approach using ultraviolet-spectroscopy as a powerful spectral resolution tool for simultaneously estimating newly approved eye solution in the presence of extremely carcinogenic impurity aided with various greenness and whiteness assessment perspectives: Application to aqueous humor

Attia,

El-Olemy,

Abbas

et al. 2023

Journal of Chemical Research

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Drug impurities are now seen as a major threat to drug safety around the world, especially when it comes to carcinogenic impurities. Here, we present the first spectrophotometric approach for the quantification of lignocaine and fluorescein in the presence of 2,6-xylidine, lignocaine’s carcinogenic impurity. The approach depends on overcoming unresolved bands through a data processing strategy employing 10 affordable, simple, and sensitive spectrophotometric methods. Fluorescein analysis (1–16 μg mL−1) was performed using direct ultraviolet spectrophotometry (D0) at 478 nm; then, the ratio subtraction method allowed the removal of interference caused by the fluorescein spectrum. From the resulting ratio spectra, 2,6-xylidine (40–160 μg mL−1) can be efficiently determined at 280 nm. However, lignocaine (72–320 μg mL−1) was analyzed using different ultraviolet-based methods, including continuous wavelet transform, ratio derivative by Savitzky–Golay filters, mean centering, second derivative of ratio spectra, ratio spectra difference spectrophotometry, extended ratio subtraction, absorbance subtraction, Q-absorbance ratio, and area under the curve. In line with International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH), the presented approach was evaluated by its coefficients of determination, detection limits, quantification limits, and relative standard deviations. Similarly, the developed approach was assessed for whiteness, greenness, and sustainability using five assessment tools, including National Environmental Method Index, Eco-Scale Assessment, Complementary Green Analytical Procedure Index, Analytical Greenness Metric, and RGB12, offering promising results. Owing to the satisfactory analytical performance, besides the sustainability, affordability, simplicity, and cost efficiency of the presented methods, their application for quality control and in situ analysis in minimal-infrastructure laboratories increases, increasing the surveillance potential.

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Section: Resultsmentioning

confidence: 99%

A sustainable data processing approach using ultraviolet-spectroscopy as a powerful spectral resolution tool for simultaneously estimating newly approved eye solution in the presence of extremely carcinogenic impurity aided with various greenness and whiteness assessment perspectives: Application to aqueous humor

Attia,

El-Olemy,

Abbas

et al. 2023

Journal of Chemical Research

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“…The literature review revealed several analytical methods for the quantitative determination of bromhexine HCl. These methods include spectrophotometry [7], liquid chromategraphy [8] and gas chromatography [9], whereas lidocaine HCl analytical methods in the literature include spectrophotometry [10,11], electrochemical methods [12,13], HPLC [14,15], and GLC [16]. Oxytetracycline HCl literature survey revealed several methods including spectrophotometry [17], HPLC [18,19], and electrochemical methods [20,21].…”

Section: Introductionmentioning

confidence: 99%

Critical assessment of smart calculation-based spectroscopy versus chemometric-assisted methods: Application to combined antibiotic formulations

et al. 2022

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This work describes a comparative study of two multivariate chemometric and univariate spectrophotometric methods for the determination of a ternary drug mixture containing oxytetracycline HCl, bromhexine HCl, and lidocaine HCl. All methods show high sensitivity and similar linearity range. Meanwhile, the chemometric method has the advantage of higher accuracy, higher specificity and better regression parameters. The two spectrophotometric methods are constant multiplication coupled with spectrum subtraction and successive ratio subtraction coupled with spectrum subtraction while the chemometric method used partial least square and principal component regression models. In addition, a spiking technique was used to increase the concentration of bromhexine HCl in the dosage form, allowing its determination despite its low contribution. Methods were successfully applied in the dosage form Oxyclear® veterinary injection in pure powder as well as in its pharmaceutical formulation. Statistical comparison showed no significant difference between the developed methods and the reference method.

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“…Green Analytical Chemistry is defined briefly as the application of chemical methodologies and procedures to reduce the use of hazardous reagents, solvents and chemicals. This concept has been targeted and achieved in our study with validated accuracy, precision and sensitivity of the proposed assay techniques, Atomic Absorption Spectroscopy (AAS) [1].…”

Section: Introductionmentioning

confidence: 99%

Green Atomic Absorption Spectroscopic Methods for the Determination of Rabeprazole Sodium and Fluvastatin Sodium in Pure and Pharmaceutical Dosage Forms

Kamal

Morshedy

Saad

et al. 2021

IRJPAC

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Aims: Novel green analytical methods have been proposed for the assay of Rabeprazole sodium and Fluvastatin sodium in their pure and formulated dosage forms. Study Design: The methods determine each drug through the estimation of its sodium content, using Flame Atomic Absorption Spectroscopy at wavelength 589 nm. Place and Duration of Study: Central laboratory at Faculty of Pharmacy, Damanhour University. Time duration January-March, 2020. Methodology: Methods are developed and optimized for maximum sensitivity, selectivity and degree of greenness. Linearity is achieved in the range of 8.29- 66.33 ppm of Rabeprazole sodium (equivalent to 0.5- 4 ppm Na) and 14.13- 141.32 ppm of Fluvastatin sodium (equivalent to 0.75 -7.5 ppm Na). The proposed assays are fully validated regarding ICH guidelines. Results: Atomic spectroscopic assays are compared to reported spectrophotometric ones for each drug separately using Student t-test and F-variance ratio. Conclusion: Satisfactory values indicate good agreement and the insignificant difference between both methods. The obtained percentages of recovery (99-101%) indicate no interference from excipients in formulation matrices.

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Green spectrophotometric methods for the determination of a binary mixture of lidocaine hydrochloride and cetylpyridinium chloride in the presence of dimethylaniline

Cited by 17 publications

References 41 publications

Critical assessment of smart calculation-based spectroscopy versus chemometric-assisted methods: Application to combined antibiotic formulations

Green Atomic Absorption Spectroscopic Methods for the Determination of Rabeprazole Sodium and Fluvastatin Sodium in Pure and Pharmaceutical Dosage Forms

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