Green Hydrotropic Technology as a Convenient Tool for the Handling of Poor Water-Soluble Candidates Proceeding Their Economic Analytical Measurements

Hamd, Mohamed A. El; El-Maghrabey, Mahmoud; Almawash, Saud; El-Shaheny, Rania

doi:10.1007/978-3-030-96534-1_6

Cited by 1 publication

(1 citation statement)

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“…The environmental friendliness of an analytical process was evaluated from sample collection to the final assessment using a new tool designated GAPI [36, 55]. GAPI can be utilized as a five‐pentagram symbol to assess how each step of an analytical technique affects the environment.…”

Section: Resultsmentioning

confidence: 99%

Isoquinoline‐based intrinsic fluorescence assessment of erythropoiesis‐stimulating agent, Roxadustat (FG‐4592), in tablets: applications to content uniformity and human plasma evaluation

Batakoushy,

Hafez,

Soliman

et al. 2024

Luminescence

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In the present study, a first validated and green spectrofluorimetric approach for its assessment and evaluation in different matrices was investigated. After using an excitation wavelength of 345 nm, Roxadustat (ROX) demonstrates a highly native fluorescence at an emission of 410 nm. The influences of experimental factors such as pH, diluting solvents, and different organized media were tested, and the most appropriate solvent choice was ethanol. It was confirmed that there was a linear relationship between the concentration of ROX and the relative fluorescence intensity in the range 60.0–1000.0 ng ml−1, with the limit of detection and limit of quantitation, respectively, being 17.0 and 53.0 ng ml−1. The mean recoveries % [±standard deviation (SD), n = 5] for pharmaceutical preparations were 100.11% ± 2.24%, whereas for plasma samples, they were 100.08 ± 1.08% (±SD, n = 5). The results obtained after the application of four greenness criteria, Analytical Eco‐Scale metric, NEMI, GAPI, and AGREE metric, confirmed its eco‐friendliness. In addition, the whiteness meter (RGB12) confirmed its level of sustainability. The International Council for Harmonisation (ICH) criteria were used to verify the developed method through the study in both spiked plasma samples and content uniformity evaluation. An appropriate standard for various applications in industry and quality control laboratories was developed.

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Section: Resultsmentioning

confidence: 99%