Green chemistry oriented multi-component strategy to hybrid heterocycles

Abstract

An oxindole decorated 4H-chromene scaffold has been synthesized in water under catalyst-free reaction conditions at ambient temperature by integrating the guiding principles of Diversity Oriented Synthesis (DOS) and green chemistry.

Design and synthesis of Azolidinedione/Thiazolidinediones teth-ered benzo[f]chromene derivatives and there in silico evaluation as tubulin inhibitors

“…We are actively engaged in accessing hybrid heterocyclic scaffolds through multicomponent reactions by integrating the concepts of diversity oriented synthesis and bioisosterism particularly build/ couple/pair strategy. [13][14][15] Recently we have reported the synthesis of double ring replacement analogues of 4-heterocycle substituted 4H-chromenes. 16 The synthesis of azolidinedione/thiazolidinediones tethered benzochromene analogues were carried out as outlined in Figure 3 & Figure 4.…”

Design and synthesis of benzothiazole/thiophene-4H-chromene hybrids

“…Our research group is actively engaged in developing multicomponent reaction protocols for accessing diverse scaffolds particularly 4-heterocycle-substituted-4H-chromene with inherent exibility for incorporating appendages including replacing the benzene ring of chromene moiety by heterocyclic ring, by innovative design and synthesis of building blocks. [28][29][30][31][32][33][34] Herein we disclose the design ( Fig. 1) and synthesis of hybrid heterocyclic's by simultaneous incorporation of substituent's at 3 and 4 positions of 4H-chromenes in an efficient three component reaction (Fig.…”

A Bioisosteric and Scaffold Hopping Approach for the Design and Synthesis of Double Ring Replacement Analogues of 4‐Aryl‐4H‐Chromenes and in silico Tubulin Inhibitor Studies

“…Recently, we reported the synthesis of 4‐heterocycle substituted 4 H ‐chromenes by the replacement of aryl group at 4‐position with a heterocycle, in an eco‐friendly approach …”

“…Recently, we reported the synthesis of 4-heterocycle substituted 4H-chromenes by the replacement of aryl group at 4-position with a heterocycle, in an eco-friendly approach. [27] Herein we disclose the three component reaction of isosteric analogues of salicylaldehyde with heterocycle carbon nucleophiles and malononitrile for the synthesis of bioisosteric analogues of 4-aryl-4H-chromenes (Figure 3).…”