Green chemistry for chemical synthesis

Li, Chao‐Jun; Trost, Barry M.

doi:10.1073/pnas.0804348105

Cited by 782 publications

(361 citation statements)

References 67 publications

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“…T he ongoing pursuit of synthetic efficiency combined with the increasing emphasis on sustainability inspires chemists to explore novel approaches to construct chemical products more efficiently, cleanly, under milder conditions and in an environmentally benign manner 1,2 . Although the past several decades have witnessed tremendous successes of transition-metal catalysis in organic chemistry, the difficulty associated with metal residues has led to concerns in, for example, the pharmaceutical and electronic industries.…”

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confidence: 99%

Empowering a transition-metal-free coupling between alkyne and alkyl iodide with light in water

Liu

2015

Nat Commun

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132

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Methods to assemble alkynes are essential for synthesizing fine chemicals, pharmaceuticals and polymeric photo-/electronic materials. Using light as a clean energy form and water as a green solvent has the potential to make synthetic chemistry more environmentally friendly. Here we present a transition-metal-free coupling protocol between aryl alkyne and alkyl iodide enabled by photoenergy in water. Under ultraviolet irradiation and in basic aqueous media, aryl alkynes efficiently couple with a wide range of alkyl iodides including primary, secondary and tertiary ones under mild conditions. A tentative mechanism for the coupling is also proposed.

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confidence: 99%

Empowering a transition-metal-free coupling between alkyne and alkyl iodide with light in water

Liu

2015

Nat Commun

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132

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“…In this regard, water can best meet the requirements (3,5). The types of organic reactions in water are as diverse as those in nonaqueous conditions, and many remarkable reviews have been published so far on specific topics in this field (1,(5)(6)(7)(8)(9).…”

Section: Water As An Alternative Solventmentioning

confidence: 99%

“…According to data, generally, HPAs are much stronger than H 3 PO 4 and also than the usual inorganic acids (HCl, H 2 SO 4 , HNO 3 , and HBr) and even such strong acids as HClO 4 and CF 3 SO 3 H. It is notable that sulfuric acid ranks 2-5 units of pKa below HPAs (29).…”

Section: Hpasmentioning

confidence: 99%

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Heteropoly acids-catalyzed organic reactions in water: doubly green reactions

Heravi

Fard

Faghihi

2013

Green Chemistry Letters and Reviews

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The organic reactions in water, as the most significant green solvent, have attracted much attention due to their unique properties over conventional organic ones. In the catalytic area, heteropoly acids (HPAs) are also promising green solid acids to replace environmentally harmful liquid acid catalysts. Herein, we wish to report the organic reactions catalyzed by HPAs, their salt, and polyoxometalates (POMs) in aqueous systems.

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“…[1] 4-Aminoantipyrine belongs to the class of phenazones, a predominantly useful heterocyclic compounds, known for their significant role in organic synthesis [2] and diverse biological activity. [3] Benzil (an aromatic 1,2 diketone) is a common building block in organic synthesis which is also reported to be a strong inhibitor of mammalian carboxylesterase enzymes.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Crystal Structure and in vitro DNA Binding Studies of Combretastatin A-4 Analogue

Rizvi¹,

Dangat²,

Yaseen³

et al. 2015

Croat. Chem. Acta

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Synthesis of a novel Combretastatin A-4 analogue using Schiff's reaction of benzil and 4-aminoantipyrine has been achieved under solvent free conditions. The structure of compound was examined spectroscopically and confirmed from single crystal diffraction studies. The synthesized Combretastatin A-4 analogue was investigated for its DNA binding ability as the plausible mechanism for its antitumor activity. The binding propensity of the synthesized compound with calf-thymus (CT) DNA was monitored with absorption and emission spectrophotometric titrations. The calculations predict a binding constant of 7.24 × 10 4 for the complex of the synthesized compound with CT DNA which is comparable in magnitude to that of DNA binding of bactericidal drug enoxacin and typical intercalation indicator ethidium bromide (EB). Competitive binding studies of the synthesized compound with EB using fluorescence titration reveal that it displaces the DNA-bound EB and binds in intercalative mode which was further supported by circular dichroism (CD) spectroscopy. The probable site and binding energy of the compound with DNA was further theoretically investigated by molecular docking studies. The significant DNA binding ability of the synthesized Combretastatin A4 analogue as revealed from this study could be related to the anticancer activity of the Combretastatin A4.

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Green chemistry for chemical synthesis

Cited by 782 publications

References 67 publications

Empowering a transition-metal-free coupling between alkyne and alkyl iodide with light in water

Empowering a transition-metal-free coupling between alkyne and alkyl iodide with light in water

Heteropoly acids-catalyzed organic reactions in water: doubly green reactions

Synthesis, Crystal Structure and in vitro DNA Binding Studies of Combretastatin A-4 Analogue

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