Green biosynthesis of berberine-mediated silver nanorods: Their protective and antidiabetic effects in streptozotocin-induced diabetic rats

Khalaf, Yousif H.; Dawood, Yousaf; Khashan, Atheer A.

doi:10.1016/j.rechem.2022.100722

Cited by 9 publications

(2 citation statements)

References 66 publications

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“…Induction with multiple small doses is considered better in maintaining blood glucose levels, but does not completely damage pancreatic β cells so that mice's blood glucose levels can return to normal after STZ induction is stopped. Fasting for too long before the injection will also affect the success of developing diabetes in mice (Khalaf et al, 2023).…”

Section: Blood Glucose Observation Of Micementioning

confidence: 99%

Histopathological Picture of the Pancreas of Mice (Mus Musculus) Diabetes Induced by Streptozotocin-Sukrosa by Giving Pepaya Seed Extract (Carica Papaya L.)

Sitompul,

Christy,

Sani

et al. 2024

JOSR

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This study aimed to investigate the potential of papaya seed extract as an antihyperglycemic agent and to determine the histopathological features of the pancreas of female mice induced by streptozotocin-sucrose. The study used female DDY mice and divided them into five groups, including a negative control group, a positive control group, and three test groups given different doses of papaya seed methanol extract. The parameters measured were the decrease in fasting blood glucose levels, the number, diameter, and area of the islets of Langerhans in each group. The data was analyzed using the one-way ANOVA method with a confidence level of 95% followed by a comparison test using the Least Significant Difference method. The results showed that the methanol extract of papaya seeds has the potential to reduce blood glucose levels and improve the histological structure of the pancreas of diabetic mice induced by streptozotocin-sucrose at an optimum dose of 100 mg/kgBW. There was a significant difference in reducing blood glucose levels between the negative control group and the test group given 100 mg/kgBW papaya seed methanol extract after seven days of treatment. After fourteen days, there was a significant difference between the negative control group and test groups I, II, and III. Although no significant differences were found in the number, diameter, and area of the islets of Langerhans through morphometric photo testing, microscopic photo testing showed that test group I had the best histopathological picture with no vacuolization and necrosis found.

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Section: Blood Glucose Observation Of Micementioning

confidence: 99%

Histopathological Picture of the Pancreas of Mice (Mus Musculus) Diabetes Induced by Streptozotocin-Sukrosa by Giving Pepaya Seed Extract (Carica Papaya L.)

Sitompul,

Christy,

Sani

et al. 2024

JOSR

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“…The nanomaterial obtained consists of a metallic particle surrounded by an organic matrix corresponding to the residual molecules of the extract adsorbed on the metallic surface. These materials have been used in biomedicine for the treatment of diabetes, hypolipidemia, and diseases involving inflammatory processes [ 19 , 20 , 21 , 22 , 23 , 24 ]. In addition to being cost-effective and environmentally friendly, the biological approach offers several advantages over traditional physical and chemical methods.…”

Section: Introductionmentioning

confidence: 99%

Monocyte (THP-1) Response to Silver Nanoparticles Synthesized with Rumex hymenosepalus Root Extract

Alvarez-Cirerol,

Galván-Moroyoqui,

Rodríguez-León

et al. 2024

Nanomaterials

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The study, synthesis, and application of nanomaterials in medicine have grown exponentially in recent years. An example of this is the understanding of how nanomaterials activate or regulate the immune system, particularly macrophages. In this work, nanoparticles were synthesized using Rumex hymenosepalus as a reducing agent (AgRhNPs). According to thermogravimetric analysis, the metal content of nanoparticles is 55.5% by weight. The size of the particles ranges from 5–26 nm, with an average of 11 nm, and they possess an fcc crystalline structure. The presence of extract molecules on the nanomaterial was confirmed by UV-Vis and FTIR. It was found by UPLC-qTOF that the most abundant compounds in Rh extract are flavonols, flavones, isoflavones, chalcones, and anthocyanidins. The viability and apoptosis of the THP-1 cell line were evaluated for AgRhNPs, commercial nanoparticles (AgCNPs), and Rh extract. The results indicate a minimal cytotoxic and apoptotic effect at a concentration of 12.5 μg/mL for both nanoparticles and 25 μg/mL for Rh extract. The interaction of the THP-1 cell line and treatments was used to evaluate the polarization of monocyte subsets in conjunction with an evaluation of CCR2, Tie-2, and Arg-1 expression. The AgRhNPs nanoparticles and Rh extract neither exhibited cytotoxicity in the THP-1 monocyte cell line. Additionally, the treatments mentioned above exhibited anti-inflammatory effects by maintaining the classical monocyte phenotype CD14++CD16, reducing pro-inflammatory interleukin IL-6 production, and increasing IL-4 production.

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Nano-engineered silver rods from Pleurolobus gangeticus root extract and their antilithiatic and cytoprotective role on oxalate injured renal epithelial cells

Mohan,

Krishna,

Stephy

et al. 2023

Biocatalysis and Agricultural Biotechnology

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Green biosynthesis of berberine-mediated silver nanorods: Their protective and antidiabetic effects in streptozotocin-induced diabetic rats

Cited by 9 publications

References 66 publications

Histopathological Picture of the Pancreas of Mice (Mus Musculus) Diabetes Induced by Streptozotocin-Sukrosa by Giving Pepaya Seed Extract (Carica Papaya L.)

Histopathological Picture of the Pancreas of Mice (Mus Musculus) Diabetes Induced by Streptozotocin-Sukrosa by Giving Pepaya Seed Extract (Carica Papaya L.)

Monocyte (THP-1) Response to Silver Nanoparticles Synthesized with Rumex hymenosepalus Root Extract

Nano-engineered silver rods from Pleurolobus gangeticus root extract and their antilithiatic and cytoprotective role on oxalate injured renal epithelial cells

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