Green approach on the development of lock-and-key polymers for API purification

Viveiros, Raquel; Lopes, Maria Inês; Heggie, William; Casimiro, Teresa

doi:10.1016/j.cej.2016.09.040

Cited by 28 publications

(42 citation statements)

References 28 publications

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“…To verify the extent to which polymerization occurs when using different ratios of glycerol in the dimethacrylate systems, middle infrared spectroscopy (MIR) could be used [17][18][19][20]. Scanning electron microscope (SEM) is widely used to analyze the morphological aspects of the polymers [25,26].…”

Section: Introductionmentioning

confidence: 99%

Dimethacrylate polymers with different glycerol content

Alarcon

Gaglieri

Bannach

2018

J Therm Anal Calorim

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The objectives of this study were to verify thermal properties, degree of conversion, and morphological features of several dimethacrylate polymers with different glycerol content and obtain the better proportion system to decrease cost of final polymer. These polymers were synthesized by photopolymerization, which has economic and ecological advantages. The glycerol can be used as a coinitiator in photopolymerization and has the advantage of being inexpensive and non-toxic; thus, it is in the scope of the green chemistry principles. Simultaneous thermogravimetry-differential thermal analysis and derivative thermogravimetric, differential scanning calorimetry, middle infrared spectroscopy, and scanning electronic microscopy were used to determine thermal properties, degree of conversion, and morphological characteristics of polymers obtained. The thermoanalytical results showed that glycerol addition in the dimethacrylate system caused few modifications in the thermal stability of the polymer and thermal events when compared with pure polymers (without glycerol). Two dimethacrylate systems (UDMA/glycerol and Bis-GMA/glycerol) showed good results for conversion degree and morphological aspects when compared with pure systems.

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Section: Introductionmentioning

confidence: 99%

Dimethacrylate polymers with different glycerol content

Alarcon

Gaglieri

Bannach

2018

J Therm Anal Calorim

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“…Moreover, both the synthesized polymeric materials are characterized by m values above 1, which is indicative of a cooperative adsorption. This kind of process occurs when the binding of one molecule affects the binding of others [35]. Based on the obtained R 2 values, which were shown in Table 4, SUT adsorption on the prepared MIP better fit the Langmuir model.…”

Section: Imprinting Efficacy and Selectivitymentioning

confidence: 73%

Molecularly Imprinted Polymers (MIPs) as Theranostic Systems for Sunitinib Controlled Release and Self-Monitoring in Cancer Therapy

et al. 2020

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Cytotoxic agents that are used conventionally in cancer therapy present limitations that affect their efficacy and safety profile, leading to serious adverse effects. In the aim to overcome these drawbacks, different approaches have been investigated and, among them, theranostics is attracting interest. This new field of medicine combines diagnosis with targeted therapy; therefore, the aim of this study was the preparation and characterization of Molecularly Imprinted Polymers (MIPs) selective for the anticancer drug Sunitinib (SUT) for the development of a novel theranostic system that is able to integrate the drug controlled release ability of MIPs with Rhodamine 6G as a fluorescent marker. MIPs were synthesized by precipitation polymerization and then functionalized with Rhodamine 6G by radical grafting. The obtained polymeric particles were characterized in terms of particles size and distribution, ξ-potential and fluorescent, and hydrophilic properties. Moreover, adsorption isotherms and kinetics and in vitro release properties were also investigated. The obtained binding data confirmed the selective recognition properties of MIP, revealing that SUT adsorption better fitted the Langmuir model, while the adsorption process followed the pseudo-first order kinetic model. Finally, the in vitro release studies highlighted the SUT controlled release behavior of MIP, which was well fitted with the Ritger-Peppas kinetic model. Therefore, the synthesized fluorescent MIP represents a promising material for the development of a theranostic platform for Sunitinib controlled release and self-monitoring in cancer therapy.

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“…The Langmuir model, as shown in Equation (1), was used to correlate the experimental equilibrium data considering monolayer adsorption on a uniform surface containing a finite number of uniform adsorption sites within the polymer, which means that no further adsorption occurs at this site [ 24 ]. The maximum adsorption of the surface can be obtained when the surface reaches saturation.…”

Section: Methodsmentioning

confidence: 99%

Performance Assessment of Ordered Porous Electrospun Honeycomb Fibers for the Removal of Atmospheric Polar Volatile Organic Compounds

Wang

Chang

2018

Nanomaterials

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This study explored a new facile method of preparing ordered porous electrospun honeycomb fibers to obtain the most promising composites for maximal adsorption of volatile organic compounds (VOCs). The self-assembly ordered porous material (OPM) and polyacrylonitrile (PAN) were formulated into a blend solution to prepare honeycomb fibers. SEM and TEM images showed that OPM was effectively bonded in PAN fibers because of the composite’s structure. Acetone was used as a model to assess the VOC adsorption performances of electrospun honeycomb fibers with different OPM contents. Experimental results revealed that the adsorption capacity of honeycomb fibers increased with the increase of loaded OPM within the PAN fibers. The highest adsorption capacity was 58.2 μg g−1 by the fibers containing with 60% OPM in weight. After several recycling times, the adsorption capacities of the reused honeycomb fibers were almost the same with the fresh fibers. This finding indicated that the electrospun honeycomb fibers have potential application in removing VOCs in the workplace, and promote the performance of masks for odor removal.

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Green approach on the development of lock-and-key polymers for API purification

Cited by 28 publications

References 28 publications

Dimethacrylate polymers with different glycerol content

Dimethacrylate polymers with different glycerol content

Molecularly Imprinted Polymers (MIPs) as Theranostic Systems for Sunitinib Controlled Release and Self-Monitoring in Cancer Therapy

Performance Assessment of Ordered Porous Electrospun Honeycomb Fibers for the Removal of Atmospheric Polar Volatile Organic Compounds

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