Green analytical chemistry in the determination of organic pollutants in the aquatic environment

Farré, Marinella; Pérez, Sandra; Gonçalves, C.; Alpendurada, M.F.; Barceló, Damià

doi:10.1016/j.trac.2010.07.016

Cited by 125 publications

(48 citation statements)

References 130 publications

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“…An isocratic procedure was achieved using the vancomycin-based CSP (Chirobiotic TM V column) with 150 × 2.1 mm i.d., with a flow rate of 0.32 mL min −1 and the column oven set at 20 • C. Several attempts were performed to achieve the best condition for enantiomeric resolution, as varying the proportion of ethanol, the column oven temperature and the flow rate, in order to achieve enantioseparation for all target pharmaceuticals within the shortest elution time. The conditions established used ethanol as organic solvent as recommend by green chromatography method development directives [48]. The enantioseparation of sixteen enantiomers of multi-therapeutic classes using ethanol and ammonium acetate buffer with a low flow rate (0.32 mL min −1 ) was achieved in 30 minutes (Fig.…”

Section: Enantiomeric Resolutionmentioning

confidence: 99%

Enantiomeric fraction evaluation of pharmaceuticals in environmental matrices by liquid chromatography-tandem mass spectrometry

Ribeiro

Santos

Maia

et al. 2014

Journal of Chromatography A

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a b s t r a c tThe interest for environmental fate assessment of chiral pharmaceuticals is increasing and enantioselective analytical methods are mandatory. This study presents an enantioselective analytical method for the quantification of seven pairs of enantiomers of pharmaceuticals and a pair of a metabolite. The selected chiral pharmaceuticals belong to three different therapeutic classes, namely selective serotonin reuptake inhibitors (venlafaxine, fluoxetine and its metabolite norfluoxetine), beta-blockers (alprenolol, bisoprolol, metoprolol, propranolol) and a beta 2 -adrenergic agonist (salbutamol). The analytical method was based on solid phase extraction followed by liquid chromatography tandem mass spectrometry with a triple quadrupole analyser. Briefly, Oasis® MCX cartridges were used to preconcentrate 250 mL of water samples and the reconstituted extracts were analysed with a Chirobiotic TM V under reversed mode. The effluent of a laboratory-scale aerobic granular sludge sequencing batch reactor (AGS-SBR) was used to validate the method. Linearity (r 2 > 0.99), selectivity and sensitivity were achieved in the range of 20-400 ng L −1 for all enantiomers, except for norfluoxetine enantiomers which range covered 30-400 ng L −1 . The method detection limits were between 0.65 and 11.5 ng L −1 and the method quantification limits were between 1.98 and 19.7 ng L −1 . The identity of all enantiomers was confirmed using two MS/MS transitions and its ion ratios, according to European Commission Decision 2002/657/EC. This method was successfully applied to evaluate effluents of wastewater treatment plants (WWTP) in Portugal. Venlafaxine and fluoxetine were quantified as non-racemic mixtures (enantiomeric fraction / 0.5). The enantioselective validated method was able to monitor chiral pharmaceuticals in WWTP effluents and has potential to assess the enantioselective biodegradation in bioreactors. Further application in environmental matrices as surface and estuarine waters can be exploited.

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Section: Enantiomeric Resolutionmentioning

confidence: 99%

Enantiomeric fraction evaluation of pharmaceuticals in environmental matrices by liquid chromatography-tandem mass spectrometry

Ribeiro

Santos

Maia

et al. 2014

Journal of Chromatography A

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“…; these products may be hazardous to human health and even for the environment. 15,16 From an economic point of view, GAC has also exerted a positive influence on reducing operating costs and the treatment of waste generated by analytical procedures. In addition, the use of environmentally friendly procedures is required for International Organization for Standardization (ISO) 14000 certification.…”

Section: −14mentioning

confidence: 99%

A rapid, eco-friendly, and reliable microplate method for determination of Cr(VI)

Coreño-Alonso¹,

Jiménez²,

López-Martínez³

et al. 2017

Turk J Chem

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Abstract:In the present work, the reaction of Cr(VI) with 1,5-diphenylcarbazide in microplates (enzyme-linked immunosorbent assay microtiter plate) and a subsequent determination in a plate reader at 540 nm were performed. The Employing the proposed method, the limit of detection (5.95 µ g L −1 ) of Cr(VI) was lower than that obtained with the traditional method. Thus, the analytical results obtained suggest that this methodology is faster, more economical, and more environmentally friendly than the traditional method.

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“…10,11 Os biossensores são definidos 12 como um subgrupo dos sensores químicos capazes de proporcionar informação analítica quantitativa ou semiquantitativa, usando um elemento de reconhecimento biológico (como enzimas, anticorpos, proteínas, tecidos, microorganismos) em contato a transdutores químicos ou físicos (como eletroquímicos, ópticos, térmicos, etc). Dentre as substâncias biológicas mais usadas, destacam-se as enzimas, que podem ser encontradas em sua forma purificada ou presentes em microorganismos ou em porções de tecido animal e vegetal.…”

Section: Introductionunclassified

Development of a Electrochemical Biosensor Obtained from Vegetable Extract for the Triglycerides Determination in Biodiesel

Moino¹,

Guilherme²,

Nogueira³

2014

Revista Virtual De Química

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Biodiesel is a renewable energy source, alternative to fossil fuels, which has received much attention because it presents similar characteristics and, in some cases, even better than mineral diesel. However, to ensure the quality control of this biofuel, the National Petroleum Agency (ANP) has set appropriate limits to maintain their chemical and physical-chemical characteristics. In this context, a biosensor based on carbon peroxidase from turnip extract was used for the determination of unreacted triglycerides in samples of biodiesel. The device tested presented accuracy, simplicity and low cost. The results when compared with gas chromatography show a variation of 5.8 % in the triglycerides concentration and a linear region of 5.5 to 55 µmol L -1 and a detection limit of 4.0 10 -8 mol L -1 (IUPAC method). Analyses performed by biosensors fall into the Green Analytical Chemistry because they use few reagents and generate a low level of waste.Keywords: Enzymatic biosensor; triglyceride; peroxidase; biodiesel. ResumoUma fonte energética renovável, alternativa aos combustíveis fósseis, que tem recebido bastante atenção é o biodiesel, por apresentar características similares e, em alguns casos, até melhores que o diesel mineral. No entanto, para garantir o controle da qualidade deste biocombustível, a Agência Nacional do Petróleo e Biocombustiveis (ANP), estabelece limites considerados adequados para manter suas características químicas e físico-químicas. Neste contexto, um biossensor de pasta de carbono a base de peroxidase, proveniente de extrato de nabo, foi utilizado para a determinação de triglicerídeos não reagidos em amostras de biodiesel. O dispositivo apresentou precisão das medidas, além de simplicidade de utilização e baixo custo. Os resultados obtidos foram comparados com a cromatografia gasosa, obtendo-se uma variação de 3,37% nos teores, com uma região linear de 5,5 e 55 µmol L -1 e limite de detecção de 4,0 10 -8 mol L -1 (método IUPAC). As análises com biossensores se enquadram na Química Analítica Verde, pois utilizam poucos reagentes e geram baixo índice de resíduos.Palavras-chave: Biossensor enzimático; triglicerídeo; peroxidase; biodiesel.

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Green analytical chemistry in the determination of organic pollutants in the aquatic environment

Cited by 125 publications

References 130 publications

Enantiomeric fraction evaluation of pharmaceuticals in environmental matrices by liquid chromatography-tandem mass spectrometry

Enantiomeric fraction evaluation of pharmaceuticals in environmental matrices by liquid chromatography-tandem mass spectrometry

A rapid, eco-friendly, and reliable microplate method for determination of Cr(VI)

Development of a Electrochemical Biosensor Obtained from Vegetable Extract for the Triglycerides Determination in Biodiesel

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