Gray matter volume differences and the effects of smoking on gray matter in schizophrenia

Tregellas, Jason R.; Shatti, Shireen; Tanabe, Jody; Martin, Laura F.; Gibson, Linzi; Wylie, Korey P.; Rojas, Donald C.

doi:10.1016/j.schres.2007.08.019

Cited by 54 publications

(36 citation statements)

References 44 publications

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“…Results from recent studies suggest that prefrontal and OFC gray matter damage is correlated with chronic tobacco use in healthy smokers [49,50,51], and also Yagi et al [52] reported that lipopolysaccharide, which is an active component of cigarette smoke, could induce apoptosis of olfactory receptor neurons in rats. While Tregellas et al [53] investigated the effects of smoking on gray matter in schizophrenia patients, and found that smoking patients had greater gray matter volumes in lateral prefrontal and superior temporal gyri relative to nonsmoking patients. Although 4 PD patients and 4 healthy controls had a smoking history, 2 of the PD subjects had stopped smoking at least 4 years before disease onset.…”

Section: Discussionmentioning

confidence: 99%

Correlation between Progressive Changes in Piriform Cortex and Olfactory Performance in Early Parkinson’s Disease

Wu¹,

Chen²,

Fan³

et al. 2011

Eur Neurol

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Objectives: The mechanism underlying olfactory dysfunction in Parkinson’s disease (PD) remains unknown. The current study aims to investigate the relationship between sequential changes of volume change of cortex associated with olfactory function and degree of deficiency of olfactory performance in PD. Methods: Based on the arbitrary cut-off score of olfactory performance measured by ‘five odors olfactory detection arrays’, subjects were classified into three groups: PD patients with olfactory impairment (OPD, n = 12), PD without olfactory impairment (NPD, n = 14), and healthy controls without olfactory impairment (NC, n = 26). A morphometric analysis of magnetic resonance images (voxel-based morphometry; VBM) was used to investigate cortical volume change. Results: The scores of olfactory performance were higher in both NPD and OPD groups than in the NC group independent of age and disease duration, indicating that NPD subjects did have board line deficiency of olfaction though not meet the cut-off score for abnormal olfactory function. Both NPD and OPD had cortical atrophy in the parahippocampal gyrus (PCG), but only OPD also had change in orbitofrontal cortex (OFC). Correlation analysis revealed that decrement of volumes of PCG and right OFC was associated with decreased olfactory detection sensitivity, and the right OFC was also correlated to olfactory identification. However, no correlation was found between structural changes and the severity of the disease measured by UPDRS score. Conclusions: The results confirmed that atrophy in piriform cortex and orbitofrontal cortex is associated with olfactory dysfunction in early PD. Atrophy of the orbitofrontal cortex becomes significant as olfactory damage progresses. Volume measurement of olfaction-associated areas together with the assessment of olfactory function may be a sensitive indicator for the early diagnosis of PD.

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Section: Discussionmentioning

confidence: 99%

Correlation between Progressive Changes in Piriform Cortex and Olfactory Performance in Early Parkinson’s Disease

Wu¹,

Chen²,

Fan³

et al. 2011

Eur Neurol

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“…5658 However, findings in patients with schizo phrenia are inconsistent. One ROI study reported smaller grey matter volumes in the hippocampus and the dorsolat eral prefrontal cortex, 58 whereas another study reported larger grey matter volumes in the lateral prefrontal cortex and the superior temporal gyri, 57 and a recent study found no grey matter volume differences between smoking and non smoking patients with schizophrenia. 59 To control for the possible confounding effect of nicotine use, we decided to add nicotine use to the model as a covariate.…”

Section: Limitationsmentioning

confidence: 99%

Brain volume in male patients with recent onset schizophrenia with and without cannabis use disorders

Koenders

Machielsen

Meer

et al. 2015

jpn

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“…In a VBM study, smokers showed increased grey matter volume of the lateral prefrontal and superior temporal gyri compared with nonsmokers. 29 However, the sample was small, and potential confounders could not be ruled out. A recent study found smaller DLPFC volume among smoking patients, 30 while exploratory analyses of the whole brain cortical surface showed thinning limited to a region in the right occipital lobe.…”

Section: J Psychiatry Neurosci 2015;40(4)mentioning

confidence: 99%

Cigarette smoking is associated with thinner cingulate and insular cortices in patients with severe mental illness

Jørgensen

Psychol

Skjærvø

et al. 2015

jpn

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Gray matter volume differences and the effects of smoking on gray matter in schizophrenia

Cited by 54 publications

References 44 publications

Correlation between Progressive Changes in Piriform Cortex and Olfactory Performance in Early Parkinson’s Disease

Correlation between Progressive Changes in Piriform Cortex and Olfactory Performance in Early Parkinson’s Disease

Brain volume in male patients with recent onset schizophrenia with and without cannabis use disorders

Cigarette smoking is associated with thinner cingulate and insular cortices in patients with severe mental illness

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