Gray Matter Abnormalities in Type 1 and Type 2 Diabetes: A Dual Disorder ALE Quantification

Yu, Kevin; Cheing, Gladys L.Y.; Cheung, CW; Kranz, Georg S.; Cheung, Kwok-Kuen

doi:10.3389/fnins.2021.638861

Cited by 5 publications

(2 citation statements)

References 94 publications

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“…T2D is associated with neuronal degeneration (Madhusudhanan et al, 2020;Yu et al, 2021), and a variety of neurodegenerative diseases are accompanied by gray matter (GM) abnormalities (Last et al, 2017). Previous studies have documented alterations in GM in T2D patients (Garcia-Casares et al, 2014;Liu et al, 2017;Redel et al, 2018;Roy et al, 2020;Feng et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Causal Structural Covariance Network Suggesting Structural Alterations Progression in Type 2 Diabetes Patients

Zhang

Liu

Guo

et al. 2022

Front. Hum. Neurosci.

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Background and PurposeAccording to reports, type 2 diabetes (T2D) is a progressive disease. However, no known research has examined the progressive brain structural changes associated with T2D. The purpose of this study was to determine whether T2D patients exhibit progressive brain structural alterations and, if so, how the alterations progress.Materials and MethodsStructural magnetic resonance imaging scans were collected for 81 T2D patients and 48 sex-and age-matched healthy controls (HCs). Voxel-based morphometry (VBM) and causal structural covariance network (CaSCN) analyses were applied to investigate gray matter volume (GMV) alterations and the likely chronological processes underlying them in T2D. Two sample t-tests were performed to compare group differences, and the differences were corrected using Gaussian random field (GRF) correction (voxel-level p < 0.001, cluster-level p < 0.01).ResultsOur findings demonstrated that GMV alterations progressed in T2D patients as disease duration increased. In the early stages of the disease, the right temporal pole of T2D patients had GMV atrophy. As the diseases duration prolonged, the limbic system, cerebellum, subcortical structures, parietal cortex, frontal cortex, and occipital cortex progressively exhibited GMV alterations. The patients also exhibited a GMV alterations sequence exerting from the right temporal pole to the limbic-cerebellum-striatal-cortical network areas.ConclusionOur results indicate that the progressive GMV alterations of T2D patients manifested a limbic-cerebellum-striatal-cortical sequence. These findings may contribute to a better understanding of the progression and an improvement of current diagnosis and intervention strategies for T2D.

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Section: Introductionmentioning

confidence: 99%

Causal Structural Covariance Network Suggesting Structural Alterations Progression in Type 2 Diabetes Patients

Zhang

Liu

Guo

et al. 2022

Front. Hum. Neurosci.

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“…GM atrophy was not observed in subjects with diabetes, unlike in previous studies. 32,33 The follow-up period of 4 years might be insufficient to evaluate brain volume changes in middle-aged adults. Brain structural damage is an early manifestation of hyperglycaemia.…”

mentioning

confidence: 99%

Association of long‐term hyperglycaemia and insulin resistance with brain atrophy and cognitive decline: A longitudinal cohort study

Kim

Park

et al. 2023

Diabetes Obesity Metabolism

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Aim: To investigate the longitudinal changes in brain volume and cognitive function associated with diabetes at midlife, and to examine whether long-term hyperglycaemia, insulin resistance or secretory function is associated with brain atrophy and cognitive decline. Materials and Methods:We used data from 2377 participants with both baseline and 4-year follow-up brain magnetic resonance images and neuropsychological measures from the Ansan cohort of the Korean Genome Epidemiology Study. Timeweighted mean glycaemic values were calculated using all measurements over an average duration of 10.6 years from cohort initiation to baseline visits.Results: Type 2 diabetes was associated with greater white matter volume reduction (adjusted volume difference = À1.96 ml, 95% CI: À3.73, À0.18) and executive function decline (adjusted Z score difference = À0.14, 95% CI: À0.23, À0.05) during the follow-up period of 4.2 years. Decline of verbal and visual memory or verbal fluency was not associated with diabetes. Greater executive function decline was associated with higher time-weighted mean HbA1c level over the preceding 10.6 years (P < .001), but not with insulin resistance markers in the diabetes group. Participants with diabetes, whose time-weighted average HbA1c level was maintained above 6.5% over the previous decade, showed greater decline in executive function and global cognition than the normal glucose group.Conclusions: Long-term hyperglycaemia was a major independent factor associated with rapid cognitive decline in middle-aged adults with diabetes. Maintaining ideal glucose levels in diabetes at midlife might prevent later rapid cognitive decline.

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Structural characteristics of amygdala subregions in type 2 diabetes mellitus

Qiu,

Yue,

Huang

et al. 2024

Behavioural Brain Research

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Gray Matter Abnormalities in Type 1 and Type 2 Diabetes: A Dual Disorder ALE Quantification

Cited by 5 publications

References 94 publications

Causal Structural Covariance Network Suggesting Structural Alterations Progression in Type 2 Diabetes Patients

Causal Structural Covariance Network Suggesting Structural Alterations Progression in Type 2 Diabetes Patients

Association of long‐term hyperglycaemia and insulin resistance with brain atrophy and cognitive decline: A longitudinal cohort study

Structural characteristics of amygdala subregions in type 2 diabetes mellitus

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