2010
DOI: 10.1021/nl100996u
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Abstract: Although biomedical applications of carbon nanotubes have been intensively studied in recent years, its sister, graphene, has been rarely explored in biomedicine. In this work, for the first time we study the in vivo behaviors of nanographene sheets (NGS) with polyethylene glycol (PEG) coating by a fluorescent labeling method. In vivo fluorescence imaging reveals surprisingly high tumor uptake of NGS in several xenograft tumor mouse models. Distinctive from PEGylated carbon nanotubes, PEGylated NGS shows sever… Show more

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Cited by 2,202 publications
(1,684 citation statements)
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References 30 publications
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“…Compared to other conventional therapeutic techniques, PTT boasts many merits such as the simplicity, minimal invasiveness, low incidence of complications, as well as the high spatial and temporal precision of NIR light 8, 9, 10, 11. Various types of nanoagents have been explored to attain better PTT performance12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24 and in the treatment, intravenous injection of the nanoagents (to mice, for example) is followed by high‐power NIR laser irradiation for ablation 25, 26, 27, 28, 29. Despite recent progress, clinical adoption of PTT still faces several hurdles.…”
Section: Introductionmentioning
confidence: 99%
“…Compared to other conventional therapeutic techniques, PTT boasts many merits such as the simplicity, minimal invasiveness, low incidence of complications, as well as the high spatial and temporal precision of NIR light 8, 9, 10, 11. Various types of nanoagents have been explored to attain better PTT performance12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24 and in the treatment, intravenous injection of the nanoagents (to mice, for example) is followed by high‐power NIR laser irradiation for ablation 25, 26, 27, 28, 29. Despite recent progress, clinical adoption of PTT still faces several hurdles.…”
Section: Introductionmentioning
confidence: 99%
“…The spatial localization is usually achieved by biofunctionalization of the nanoparticles (NPs) surface with antigens [7,9,10]. Biofunctionalized gold nanostructures (nanorods [11], nanocubes [12], nanocages [13,14], nanoshells [15] as well as hybrid Au-Fe3O4 [16]) or graphene [17] have been successfully applied as nanoheaters in many in-vitro studies and allowed to diminish most of the drawbacks of the original method. However, cetyltrimethylammonium bromide (CTAB) used as gold nanostructures surfactant and stabilizer, demonstrated inherent toxicity.…”
Section: Introductionmentioning
confidence: 99%
“…In 2011, Liu group developed a method to label nGO-PEG with 125 I by anchoring iodine atoms on the defects and edges of GO (44). Based on this method, a number of studies have been explored.…”
Section: Radionuclide-based Imagingmentioning
confidence: 99%