Graphene-based nanomaterials for bioimaging

Lin, Jing; Chen, Xiaoyuan; Huang, Peng

doi:10.1016/j.addr.2016.05.013

Cited by 300 publications

(137 citation statements)

References 131 publications

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“…were decided for serial PET sweeps. The PET imaging exhibited CD105 particular targeting of TRC105 conjugated GO . Also a parallel study using 66 Ga named nGO–PEG for tumor‐focused on PET imaging has been conducted.…”

Section: Biomedical Applicationsmentioning

confidence: 97%

Graphene and Graphene‐Based Materials in Biomedical Science

Swetha

Manisha

Prasad

2018

Part & Part Syst Charact

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Graphene and its composite materials are very important in many disciplines of science and have been used enormously by researchers since their discovery in 2004. These are a new group of compounds, and are also wonderful model systems for quantum behavior studies. Their properties like exceptional conductivity, biocompatibility, surface area, mechanical strength, and thermal properties make them rising stars in the scientific community. Graphene and its composite compounds are utilized widely in different medical applications, for example, biosensing of biological compounds responsible for disease development, bioimaging of various cells, tissues, microorganisms, animal models, etc. In addition, they are used for enhancing and supporting the stem cell differentiation, i.e., regenerative medicine for regeneration studies of various human organs, tissue engineering in biology for the development of carrier materials, as well as in bone reformation. This review focuses on the modification procedure involved in the fabrication of graphene‐based biomaterials for various applications and recent developments in research related to graphene and graphene‐based materials in biosensing, optical sensing, gas sensing, drug, gene, protein delivery, tissue engineering, and bioimaging. In addition, the potential toxicological effects of graphene‐based biomaterials are discussed.

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Section: Biomedical Applicationsmentioning

confidence: 97%

Graphene and Graphene‐Based Materials in Biomedical Science

Swetha

Manisha

Prasad

2018

Part & Part Syst Charact

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“…Graphene materials have various applications and are widely used in the biomedical field in tumor therapy, [1][2][3] diagnostics, 4,5 bio-imaging, [6][7][8] and drug delivery. 9,10 The widespread use of graphene materials has prompted concerns about the possible human health and environmental safety impacts of these materials.…”

Section: Introductionmentioning

confidence: 99%

The mechanisms of graphene-based materials-induced programmed cell death: a review of apoptosis, autophagy, and programmed necrosis

Lin

Song

et al. 2017

IJN

159

108

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Graphene-based materials (GBMs) are widely used in many fields, including biomedicine. To date, much attention had been paid to the potential unexpected toxic effects of GBMs. Here, we review the recent literature regarding the impact of GBMs on programmed cell death (PCD). Apoptosis, autophagy, and programmed necrosis are three major PCDs. Mechanistic studies demonstrated that the mitochondrial pathways and MAPKs (JNK, ERK, and p38)- and TGF-β-related signaling pathways are implicated in GBMs-induced apoptosis. Autophagy, unlike apoptosis and necroptosis which are already clear cell death types, plays a vital pro-survival role in cell homeostasis, so its role in cell death should be carefully considered. However, GBMs always induce unrestrained autophagy accelerating cell death. GBMs trigger autophagy through inducing autophagosome accumulation and lysosome impairment. Mitochondrial dysfunction, ER stress, TLRs signaling pathways, and p38 MAPK and NF-κB pathways participate in GBMs-induced autophagy. Programmed necrosis can be activated by RIP kinases, PARP, and TLR-4 signaling in macrophages after GBMs exposure. Though apoptosis, autophagy, and necroptosis are distinguished by some characteristics, their numerous signaling pathways comprise an interconnected network and correlate with each other, such as the TLRs, p53 signaling pathways, and the Beclin-1 and Bcl-2 interaction. A better understanding of the mechanisms of PCD induced by GBMs may allow for a thorough study of the toxicology of GBMs and a more precise determination of the consequences of human exposure to GBMs. These determinations will also benefit safety assessments of the biomedical and therapeutic applications of GBMs.

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“…Owing to their unique structural, electric and optical properties, two‐dimensional (2D) single‐ or few‐layered materials, including graphene and metal dichalcogenides (e.g., MoS 2 and WS 2 ), hold great promise in many biomedical applications, such as drug/gene delivery, biosensing, photothermal therapy and photoacoustic imaging . A key challenge in these applications is the production of large‐scale, low‐defect, and size‐controllable, single‐ or few‐layered 2D materials that readily interface with diverse biomolecules.…”

Section: Figurementioning

confidence: 99%

Engineered Recombinant Proteins for Aqueous Ultrasonic Exfoliation and Dispersion of Biofunctionalized 2D Materials

Wang

et al. 2019

Chemistry A European J

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Aqueous ultrasonic exfoliation by using proteins as dispersants allows for the simultaneous production and biofunctionalization of single‐ or few‐layered 2D materials for biomedical applications. However, the production yield and quality are always a concern. Here, the production of stable, low‐defect, and biofunctionalized 2D flakes of graphene by using bifunctional chimeric polyproteins as dispersants is shown. The chimeric polyproteins contain an amphiphilic protein, hydrophobin (HFBI), to serve as the anchoring point that strongly binds to graphene layers and tandem repeats of a globular protein, GB1, to respond and transmit the ultrasonic force for efficient mechanical exfoliation. For this reason, the production yield is much higher than those obtained by using HFBI alone. Moreover, the yield, lateral size and number of layers can be fine‐tuned by the number of GB1 repeats. Other 2D materials, such as MoS2 and WS2, can also be exfoliated in the same manner, demonstrating the versatility of this approach.

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Graphene-based nanomaterials for bioimaging

Cited by 300 publications

References 131 publications

Graphene and Graphene‐Based Materials in Biomedical Science

Graphene and Graphene‐Based Materials in Biomedical Science

The mechanisms of graphene-based materials-induced programmed cell death: a review of apoptosis, autophagy, and programmed necrosis

Engineered Recombinant Proteins for Aqueous Ultrasonic Exfoliation and Dispersion of Biofunctionalized 2D Materials

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