Graphene-based field-effect transistor biosensors for the rapid detection and analysis of viruses: A perspective in view of COVID-19

Sengupta, Joydip; Hussain, Chaudhery Mustansar

doi:10.1016/j.cartre.2020.100011

Cited by 119 publications

(73 citation statements)

References 69 publications

(93 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…FET based biosensors are classified into different groups according to the technique of gate voltage application, design, gate material, and the channel region. FET based biosensors have found an extensive application in biomolecules detection [ 106 ]. Recently, this technique coupled with graphene advantages is used for COVID-19 detection.…”

Section: Sars-cov-2 Detection Based On Applied Analytical Methodsmentioning

confidence: 99%

Novel approaches for rapid detection of COVID-19 during the pandemic: A review

Ilkhani

Hedayat

Farhad

2021

Analytical Biochemistry

View full text Add to dashboard Cite

The rapid spread of the SARS-CoV-2 virus that caused the COVID-19 disease, has highlighted our urgent need for sensitive, fast and accurate diagnostic technologies. In fact, one of the main challenges for flatting COVID-19 spread charts is the ability to accurately and rapidly identify asymptomatic cases that result in spreading the virus to close contacts. SARS-CoV-2 virus mutation is also relatively rapid, which makes the detection of COVID-19 diseases still crucial even after the vaccination. Conventional techniques, which are commercially available have focused on clinical manifestation, along with molecular and serological detection tools that can identify the SARS-CoV-2 virus however, owing to various disadvantages including low specificity and sensitivity, a quick, low cost and easy approach is needed for diagnosis of COVID-19. Scientists are now showing extensive interest in an effective portable and simple detection method to diagnose COVID-19. There are several novel methods and approaches that are considered viable advanced systems that can meet the demands. This study reviews the new approaches and sensing technologies that work on COVID-19 diagnosis for easy and successful detection of SARS-CoV-2 virus.

show abstract

Section: Sars-cov-2 Detection Based On Applied Analytical Methodsmentioning

confidence: 99%

Novel approaches for rapid detection of COVID-19 during the pandemic: A review

Ilkhani

Hedayat

Farhad

2021

Analytical Biochemistry

View full text Add to dashboard Cite

show abstract

“…The drawback of this technology is the baseline drift in an aqueous environment. This limits their ability to respond to target molecules [156][157][158]. Figure 8 presents the COVID-19 biomarker sensors.…”

Section: Graphene Field Effect Transistormentioning

confidence: 99%

COVID-19 Biomarkers and Advanced Sensing Technologies for Point-of-Care (POC) Diagnosis

et al. 2021

View full text Add to dashboard Cite

COVID-19, also known as SARS-CoV-2 is a novel, respiratory virus currently plaguing humanity. Genetically, at its core, it is a single-strand positive-sense RNA virus. It is a beta-type Coronavirus and is distinct in its structure and binding mechanism compared to other types of coronaviruses. Testing for the virus remains a challenge due to the small market available for at-home detection. Currently, there are three main types of tests for biomarker detection: viral, antigen and antibody. Reverse Transcription-Polymerase Chain Reaction (RT-PCR) remains the gold standard for viral testing. However, the lack of quantitative detection and turnaround time for results are drawbacks. This manuscript focuses on recent advances in COVID-19 detection that have lower limits of detection and faster response times than RT-PCR testing. The advancements in sensing platforms have amplified the detection levels and provided real-time results for SARS-CoV-2 spike protein detection with limits as low as 1 fg/mL in the Graphene Field Effect Transistor (FET) sensor. Additionally, using multiple biomarkers, detection levels can achieve a specificity and sensitivity level comparable to that of PCR testing. Proper biomarker selection coupled with nano sensing detection platforms are key in the widespread use of Point of Care (POC) diagnosis in COVID-19 detection.

show abstract

“…Among the currently used BREs, antibodies are one of the most prominent and reliable biosensing elements for the accurate detection of the whole viral particle or their structural proteins, and sequester them from the solution [ 64 ]. The binding of these capturing antibodies to the transducer surfaces allows the production of electrical signals from chemical ones.…”

Section: Biorecognition Elementsmentioning

confidence: 99%

Towards Fully Integrated Portable Sensing Devices for COVID-19 and Future Global Hazards: Recent Advances, Challenges, and Prospects

2021

View full text Add to dashboard Cite

Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, this fatal disease has been the leading cause of the death of more than 3.9 million people around the world. This tragedy taught us that we should be well-prepared to control the spread of such infectious diseases and prevent future hazards. As a consequence, this pandemic has drawn the attention of many researchers to the development of portable platforms with short hands-on and turnaround time suitable for batch production in urgent pandemic situations such as that of COVID-19. Two main groups of diagnostic assays have been reported for the detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) including nucleic acid-based and protein-based assays. The main focus of this paper is on the latter, which requires a shorter time duration, less skilled technicians, and faces lower contamination. Furthermore, this paper gives an overview of the complementary metal-oxide-semiconductor (CMOS) biosensors, which are potentially useful for implementing point-of-care (PoC) platforms based on such assays. CMOS technology, as a predominant technology for the fabrication of integrated circuits, is a promising candidate for the development of PoC devices by offering the advantages of reliability, accessibility, scalability, low power consumption, and distinct cost.

show abstract

Graphene-based field-effect transistor biosensors for the rapid detection and analysis of viruses: A perspective in view of COVID-19

Cited by 119 publications

References 69 publications

Novel approaches for rapid detection of COVID-19 during the pandemic: A review

Novel approaches for rapid detection of COVID-19 during the pandemic: A review

COVID-19 Biomarkers and Advanced Sensing Technologies for Point-of-Care (POC) Diagnosis

Towards Fully Integrated Portable Sensing Devices for COVID-19 and Future Global Hazards: Recent Advances, Challenges, and Prospects

Contact Info

Product

Resources

About