Graphene-based analytical lab-on-chip devices for detection of viruses: A review

Sengupta, Joydip; Adhikari, Arpita; Hussain, Chaudhery Mustansar

doi:10.1016/j.cartre.2021.100072

Cited by 33 publications

(14 citation statements)

References 114 publications

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“…One improvement could be integration with lab-on-chip to clean up the sample and pre-concentrate the analyte of interest. The application of graphene in LOC devices has greatly increased their sensing capabilities [ 104 ].…”

Section: Future Outlook and Challengesmentioning

confidence: 99%

Fluorescent Biosensors for the Detection of Viruses Using Graphene and Two-Dimensional Carbon Nanomaterials

2022

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Two-dimensional carbon nanomaterials have been commonly employed in the field of biosensors to improve their sensitivity/limits of detection and shorten the analysis time. These nanomaterials act as efficient transducers because of their unique characteristics, such as high surface area and optical, electrical, and magnetic properties, which in turn have been exploited to create simple, quick, and low-cost biosensing platforms. In this review, graphene and two-dimensional carbon material-based fluorescent biosensors are covered between 2010 and 2021, for the detection of different human viruses. This review specifically focuses on the new developments in graphene and two-dimensional carbon nanomaterials for fluorescent biosensing based on the Förster resonance energy transfer (FRET) mechanism. The high-efficiency quenching capability of graphene via the FRET mechanism enhances the fluorescent-based biosensors. The review provides a comprehensive reference for the different types of carbon nanomaterials employed for the detection of viruses such as Rotavirus, Ebola virus, Influenza virus H3N2, HIV, Hepatitis C virus (HCV), and Hepatitis B virus (HBV). This review covers the various multiplexing detection technologies as a new direction in the development of biosensing platforms for virus detection. At the end of the review, the different challenges in the use of fluorescent biosensors, as well as some insights into how to overcome them, are highlighted.

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Section: Future Outlook and Challengesmentioning

confidence: 99%

Fluorescent Biosensors for the Detection of Viruses Using Graphene and Two-Dimensional Carbon Nanomaterials

2022

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“…For the fabrication of the basic structure of LOC, many organic and inorganic materials were used to date [ 10 ]. However, most of the materials are not suitable for the fabrication of GGLOC as the material is not environment-friendly.…”

Section: Green Pathways For Graphene-based Locmentioning

confidence: 99%

Prospective pathways of green graphene-based lab-on-chip devices: the pursuit toward sustainability

Sengupta¹,

Hussain

2022

Microchim Acta

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At present, analytical lab-on-chip devices find their usage in different facets of chemical analysis, biological analysis, point of care analysis, biosensors, etc. In addition, graphene has already established itself as an essential component of advanced lab-on-chip devices. Graphene-based lab-on-chip devices have achieved appreciable admiration because of their peerless performance in comparison to others. However, to accomplish a sustainable future, a device must undergo “green screening” to check its environmental compatibility. Thus, extensive research is carried out globally to make the graphene-based lab-on-chip green, though it is yet to be achieved. Nevertheless, as a ray of hope, there are few existing strategies that can be stitched together for feasible fabrication of environment-friendly green graphene-based analytical lab-on-chip, and those prospective pathways are reviewed in this paper. Graphical abstract

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“…viruses, such as Ebola, Zika, and influenza, are considered in the reviews [68,69] and are partially presented in Table 1.…”

Section: Graphene Biosensors For Detecting Bacteria and Virusesmentioning

confidence: 99%

Biosensors Based on Graphene Nanomaterials

Кулакова

Лисичкин

2022

Moscow Univ. Chem. Bull.

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This review is devoted to the development, properties, and application of biosensors based on graphene nanomaterials. It is shown that such biosensors are characterized by their sensitivity, specificity of detection of analytes, high speed, and small size. Examples of the use of graphene biosensors for the detection of viruses, bacteria, markers of socially significant diseases, and various toxins are given.

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Graphene-based analytical lab-on-chip devices for detection of viruses: A review

Cited by 33 publications

References 114 publications

Fluorescent Biosensors for the Detection of Viruses Using Graphene and Two-Dimensional Carbon Nanomaterials

Fluorescent Biosensors for the Detection of Viruses Using Graphene and Two-Dimensional Carbon Nanomaterials

Prospective pathways of green graphene-based lab-on-chip devices: the pursuit toward sustainability

Biosensors Based on Graphene Nanomaterials

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