Grape Seed Extract Supplementation and the Effects on the Biomarkers of Oxidative Stress and Metabolic Profiles in Female Volleyball Players: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Abstract

BackgroundOnly limited data are available for evaluating the effects of the administration of grape seed extract (GSE) on the metabolic status of female volleyball players.ObjectivesThis study was conducted to determine the effects of GSE administration on the metabolic status of female volleyball players.MethodsThis randomized, double-blind, placebo-controlled clinical trial was performed among 40 female volleyball players. The subjects were randomly divided into two groups, with members of the test group (n = 20) taking 300 mg of GSE twice a day for eight weeks and members of the control group (n = 20) taking a placebo pearl for the same period. Fasting blood samples were taken before and after the eight-week intervention period in order to determine the related variables.ResultsSupplementation with GSE resulted in a significant rise in the plasma glutathione (GSH) level (+265.5 ± 344.2 vs. +2.2 ± 378.2 µmol/L, P = 0.02), as well as a significant decrease in the malondialdehyde (MDA) level (-1.4 ± 2.0 vs. -0.2 ± 1.2 µmol/L, P = 0.01) when compared to the placebo group. In addition, when compared to the group that received the placebo, the subjects who received GSE had significantly decreased serum insulin concentrations (-23.4 ± 23.4 vs. +1.8 ± 25.2 pmol/L, P = 0.002), a decreased homeostasis model of assessment for insulin resistance (HOMA-IR) (-0.7 ± 0.7 vs. +0.2 ± 0.9, P = 0.002), and an increased quantitative insulin sensitivity check index (QUICKI) (+0.01 ± 0.01 vs. -0.01 ± 0.02, P = 0.03). The administration of GSE had no significant effects on creatine phosphokinase (CPK), total antioxidant capacity (TAC), nitric oxide (NO), fasting plasma glucose (FPG), and lipid concentrations when compared with the administration of the placebo. However, after controlling for baseline NO levels, age, and baseline BMI, the changes in the plasma NO concentrations were significantly different between the two groups.ConclusionsIn conclusion, taking GSE for eight weeks had beneficial effects on the plasma GSH, MDA levels, and markers of insulin metabolism of female volleyball players.

The effects of grape seed extract on glycemic control, serum lipoproteins, inflammation, and body weight: A systematic review and meta‐analysis of randomized controlled trials

“…After screening 724 studies, 15 (Abedini et al, ; Alirezaei et al, ; Argani et al, ; Clifton, ; Kar, Laight, Rooprai, Shaw, & Cummings, ; Mellen, Daniel, Brosnihan, Hansen, & Herrington, ; Park, Edirisinghe, Choy, Waterhouse, & Burton‐Freeman, ; Pourghassem‐Gargari, Abedini, Babaei, Aliasgarzadeh, & Pourabdollahi, ; Sano et al, ; Sivaprakasapillai, Edirisinghe, Randolph, Steinberg, & Kappagoda, ; Taghizadeh, Malekian, Memarzadeh, Mohammadi, & Asemi, ; Terauchi et al, ; Turki et al, ; Vigna et al, ; Ward et al, ) of them were eligible to be included in this meta‐analysis. These studies were detected by a process that is shown in Figure .…”

“…General characteristics of eligible studies are summarized in Table . The studies were conducted in Italy (Vigna et al, ), Australia (Clifton, ; Ward et al, ), Japan (Sano et al, ; Terauchi et al, ), United Kingdom (Kar et al, ), United States (Mellen et al, ; Park et al, ; Sivaprakasapillai et al, ), Iran (Abedini et al, ; Alirezaei et al, ; Argani et al, ; Pourghassem‐Gargari et al, ; Taghizadeh et al, ), and Tunisia (Turki et al, ). Studies were published between 2003 and 2017.…”

“…Studies were published between 2003 and 2017. Ten studies (Abedini et al, ; Argani et al, ; Park et al, ; Pourghassem‐Gargari et al, ; Sano et al, ; Sivaprakasapillai et al, ; Taghizadeh et al, ; Terauchi et al, ; Turki et al, ; Ward et al, ) had parallel design and other (Alirezaei et al, ; Clifton, ; Kar et al, ; Mellen et al, ; Vigna et al, ) had crossover design. One study was performed on men (Vigna et al, ), two studies (Taghizadeh et al, ; Terauchi et al, ) on women, and other studies (Abedini et al, ; Alirezaei et al, ; Argani et al, ; Clifton, ; Kar et al, ; Mellen et al, ; Park et al, ; Pourghassem‐Gargari et al, ; Sano et al, ; Sivaprakasapillai et al, ; Turki et al, ; Ward et al, ) on both sexes.…”

“…Ten studies (Abedini et al, ; Argani et al, ; Park et al, ; Pourghassem‐Gargari et al, ; Sano et al, ; Sivaprakasapillai et al, ; Taghizadeh et al, ; Terauchi et al, ; Turki et al, ; Ward et al, ) had parallel design and other (Alirezaei et al, ; Clifton, ; Kar et al, ; Mellen et al, ; Vigna et al, ) had crossover design. One study was performed on men (Vigna et al, ), two studies (Taghizadeh et al, ; Terauchi et al, ) on women, and other studies (Abedini et al, ; Alirezaei et al, ; Argani et al, ; Clifton, ; Kar et al, ; Mellen et al, ; Park et al, ; Pourghassem‐Gargari et al, ; Sano et al, ; Sivaprakasapillai et al, ; Turki et al, ; Ward et al, ) on both sexes. Totally, 825 subjects (451 in intervention and 374 in control group) were enrolled in these studies (Abedini et al, ; Alirezaei et al, ; Argani et al, ; Clifton, ; Kar et al, ; Mellen et al, ; Park et al, ; Pourghassem‐Gargari et al, ; Sano et al, ; Sivaprakasapillai et al, ; Taghizadeh et al, ; Terauchi et al, ; Turki et al, ; Vigna et al, ; Ward et al, ).…”

Estado Físico, Fisiológico E Psicossocial De Atletas Do Tae Kwon Do Na Pré-Competição

“…De fato, um elevado estresse oxidativo tem sido encontrado em atletas de combate 32,33 . Estes dados devem ser ponderados pelo fato de que a MDA é um metabólico inespecífico para avaliação do estresse oxidativo 34 , embora venha sendo usada em estudos que avaliam este fenômeno 35,36 . Quanto à PCR-us, um resultado semelhante ao do presente estudo foi observado por Garatachea et al 37 , em oito atletas de caiaque durante 42 semanas de treinamento.…”