Granulome éosinophile isolé de l’orbite

Harzallah, L.; Braham, N.; Chérifa, L. Ben; Bakir, D.; Hamdi, I.; Bellara, I.; Amara, H.; Yakoubi, M; Kraiem, C.

doi:10.1016/s0181-5512(05)81127-1

Cited by 4 publications

(1 citation statement)

References 3 publications

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“…Six prior reports in the literature described the regression of LCH in the orbit; most of which were published in the ophthalmological literature ( Table 1 ). 3 11 12 13 14 15 All the cases were single, unifocal lesions that were confirmed histologically to be LCH. A report by Glover and Grove was the first to describe the spontaneous resolution and re-ossification of LCH in a 13-year-old boy with a right orbital EG.…”

Section: Discussionmentioning

confidence: 93%

Resolution and Re-ossification of Orbital-Wall Langerhans Cell Histiocytosis Following Stereotactic Needle Biopsy

et al. 2022

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Introduction Langerhans cell histiocytosis (LCH) is a rare disease that encompasses a spectrum of clinical syndromes. It is characterized by the proliferation and infiltration of white blood cells into organs or organ systems. Reports of management of these lesions have included biopsy, resection, curettage, radiation and/or chemotherapy. Case Presentation A 40-year-old man presented with a history of right proptosis and retro-orbital pain and was found to have a lytic mass involving the greater wing of the sphenoid extending into the right orbit. A stereotactic needle biopsy using neuronavigation demonstrated this to be LCH. After no further treatment, the mass spontaneously resolved, with virtual normalization of the orbital MRI at 10 months following the needle biopsy. The bony defect of the temporal bone caused by the mass also re-ossified following the needle biopsy. Discussion This report highlights the potential for an isolated LCH lesion to regress after simple needle biopsy, an outcome only rarely reported previously. Thus, expectant management of such lesions following biopsy or initial debridement should be considered prior to proceeding with additional treatment.

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