Granulomatous mastitis due to coinfection with Histoplasma sp. and Paracoccidioides sp.: A case report

Merino-Alado, Rommie; Pineda, Jacinto; Rasquin, Juan Hernandez; Landaeta, María Eugenia; Mata-Essayag, Sofía

doi:10.1016/j.mmcr.2020.01.006

Cited by 4 publications

(6 citation statements)

References 18 publications

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“… 43 Other reports from Venezuela had shown a higher concurrence of PCM and histoplasmosis, representing over 28% of the studied cases. 44 Authors such as Shikanai-Yasuda previously report carcinoma concurrence in 0.16% to 14.1% of patients during PCM infection or after therapeutic management of PCM. In any case, a reliable and interdisciplinary study of clinical manifestations is mandatory to rapidly discard any malignancy associated with PCM lesions.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of paracoccidioidomycosis in Venezuela: a retrospective study from 1954 to 2019

Alvarado

Teixeira

Cavallera

et al. 2021

Mem. Inst. Oswaldo Cruz

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Section: Discussionmentioning

confidence: 99%

Epidemiology of paracoccidioidomycosis in Venezuela: a retrospective study from 1954 to 2019

Alvarado

Teixeira

Cavallera

et al. 2021

Mem. Inst. Oswaldo Cruz

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“…On the other hand, non-infectious contributors involve hormonal fluctuations, smoking, and autoimmune disorders such as granulomatosis with polyangiitis, giant cell arteritis, and sarcoidosis. The challenge lies in the fact that distinguishing between these entities through clinical and radiographic means is intricate 12 , 19 . In the current study, bacterial, protozoan, and fungal infections were identified, whereas instances of tuberculosis were not detected.…”

Section: Discussionmentioning

confidence: 99%

“… 1 reported an exceptionally rare instance of GM associated with Salmonella . There is also some evidence suggesting that Corynebacterium may play a role in the development of GM 12 , 18 , 19 . Taylor’s study, for instance, discovered Corynebacterium in the breast tissue of 55% of 64 GM patients, particularly among those who had fever or an abscess 18 .…”

Section: Discussionmentioning

confidence: 99%

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Investigation of multi-infections and breast disease comorbidities in granulomatous mastitis

Esmaeil,

Salih

2024

Annals of Medicine &Amp; Surgery

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Introduction: Granulomatous mastitis (GM) is an inflammatory breast disease typically caused by infection, posing diagnostic challenges. It can coexist with other breast disorders or multiple infections, which have been vaguely discussed. This study investigates the incidence of multi-infection and breast disease comorbidities in GM. Method: The study enrolled 63 females who had a confirmed diagnosis of GM. Laboratory investigations and bacterial cultures had been conducted for all the cases. The patients had undergone ultrasonography examination utilizing the LOGIQ E9 system. Core needle biopsy had been done to procure tissue samples for histopathological examination. Thorough scrutiny and assessment of patients’ records were performed. The variables encompassed age at presentation, breastfeeding data, parity, smoking status, seasonal affliction, hair-washing agents, exposure to radiation, comorbidities, and clinical, ultrasound and histopathological findings. Results: The patients’ ages ranged from 24 to 50. Breastfeeding history was positive in nearly all cases (97%). The majority of cases exhibited multiparity (81%). In total, 63.5% were passive smokers. Multi-infections were detected in 6 cases (9.5%). Among them, B. cepacia complex and Toxoplasma gondii were identified in 2 cases (3.16%). Other multi-infections involved Staphylococcus epidermidis and Toxoplasma gondii, Burkholderia cepacia and S. kloosii and Toxoplasma gondii, Staphylococcus epidermis and Brucella spp., Candida spp. and Brucella spp. Histopathological analysis revealed GM comorbidities with other breast diseases in 35% of the cases. Conclusion: Multi-infections and breast disease comorbidities may further complicate diagnosis and management of GM. The findings of this study may raise additional questions about the nature of the disease or potential complications associated with it.

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“…As manifestações clínicas, além dos dados epidemiológicos, devem ser exaustivamente coletadas, pois podem auxiliar no diagnóstico da doença, o uso de colorações fungicidas específicas, cultura, exames histopatológicos de amostras clínicas obtidas de lesões suspeitas e sorologia devem ser realizados para confirmação do diagnóstico clínico (Merino-Alado, et al, 2020). Após um reexame da biópsia pulmonar, verificou-se a detecção de partículas Groccot positivas intracelulares acompanhadas de pneumonia de células gigantes, sugestiva de infecção por fungos, manchas iniciais mostraram pequenas leveduras mais alinhadas com histoplasmose, o teste sorológico foi realizado para histoplasmose usando métodos de imunodifusão dupla (IDD) bem como para paracoccidioidomicose (IDD), os anticorpos histoplasma e paracoccidioides foram detectados por IDD.…”

Section: Discussionunclassified

Avanços e desafios no diagnóstico de paracoccidioidomicose causada pelo complexo de espécies da paracoccidioides: revisão integrativa

Trindade¹,

Diniz²,

Alves³

et al. 2022

RSD

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O artigo a seguir apresenta o diagnóstico clássico e alguns avanços da paracoccidioidomicose, doença infecciosa com espectro de evolução aguda, subaguda ou crônica causada pelo fungo Paracoccidioides spp., a doença é contraída através da inalação de partículas fúngicas transportadas pelo ar, tendo como principais sintomas a tosse, falta de ar, emagrecimento e lesões na pele ou mucosas. Os sintomas clínicos dificultam um diagnóstico correto, em vista da semelhança com outras doenças, como, por exemplo, a tuberculose e a sarcoidose, além de que em algumas situações pode haver um extenso período de tempo entre a exposição do indivíduo ao fungo e a manifestação dos sintomas. Levando isso em consideração, o objetivo do trabalho é avaliar e discorrer dos métodos de diagnósticos, bem como, identificar os novos avanços realizados pelos métodos moleculares, sorológicos, micológicos e histopatológicos para essa micose. Para esta finalidade, foram realizados uma leitura sobre estudos de casos, ensaio experimental e uma revisão sistemática.

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Granulomatous mastitis due to coinfection with Histoplasma sp. and Paracoccidioides sp.: A case report

Cited by 4 publications

References 18 publications

Epidemiology of paracoccidioidomycosis in Venezuela: a retrospective study from 1954 to 2019

Epidemiology of paracoccidioidomycosis in Venezuela: a retrospective study from 1954 to 2019

Investigation of multi-infections and breast disease comorbidities in granulomatous mastitis

Avanços e desafios no diagnóstico de paracoccidioidomicose causada pelo complexo de espécies da paracoccidioides: revisão integrativa

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