Granulomatous Angiitis of the Meninges in Sarcoidosis

Intrahepatic granulomatous arteriopathy

“…The lesions in this case do indeed bear some resemblance to those occasionally seen in sarcoidosis (Erickson, Osom & Stern, 1948;Meyer, Foley & Campagna-Pinto, 1953). In the reported cases of sarcoid vasculitis, however, the granulomata have been basically parenchymal and vascular involvement has been an accidental result of enlargement of the granulomata, either arteries or veins being involved in an indiscriminate manner.…”

Intrahepatic granulomatous arteriopathy

“…The lesions in this case do indeed bear some resemblance to those occasionally seen in sarcoidosis (Erickson, Osom & Stern, 1948;Meyer, Foley & Campagna-Pinto, 1953). In the reported cases of sarcoid vasculitis, however, the granulomata have been basically parenchymal and vascular involvement has been an accidental result of enlargement of the granulomata, either arteries or veins being involved in an indiscriminate manner.…”

Clinical and MRI phenotypes of sarcoidosis-associated myelopathy

“…Indeed, pathologic studies suggest that parenchymal brain and spinal cord lesions in neurosarcoidosis occur when leptomeningeal-based granulomatous inflammation (which can be present histopathologically even in the absence of clinical symptoms) 35 spreads in a perivascular distribution along smalland medium-sized vessels. 5,[36][37][38] Our finding that medullary enhancement in SAM was always contiguous with the surface of the spinal cord supports this theory. Of interest, the spinal meningeal lymphatics are thought to be predominantly dorsally situated, 3,39 where the BSCB is also thought to be most permeable 10 and where subpial enhancement is most frequent in SAM.…”

Sarcoidosis of the central nervous system

“…The affinity of the sarcoid granuloma for cerebral vessels has been stressed by many authors (Longcope and Freiman, 1952;Meyer et al, 1953;Reske-Nielson et al, 1962;Robert, 1962;Urich, 1967) and was striking in the pathological material obtained from the cases reported here (Figs 2 and 5). This probably offers one explanation for the variable response to corticosteroid therapy.…”

“…This probably offers one explanation for the variable response to corticosteroid therapy. Areas of cerebral ischaemia and infarction have been described in relation to granulomatous cerebral angiitis (Meyer et al, 1953) and were found in case J.S. in this series.…”

Intrahepatic granulomatous arteriopathy

“…The lesions in this case do indeed bear some resemblance to those occasionally seen in sarcoidosis (Erickson, Osom & Stern, 1948;Meyer, Foley & Campagna-Pinto, 1953). In the reported cases of sarcoid vasculitis, however, the granulomata have been basically parenchymal and vascular involvement has been an accidental result of enlargement of the granulomata, either arteries or veins being involved in an indiscriminate manner.…”

Clinical and MRI phenotypes of sarcoidosis-associated myelopathy

“…Indeed, pathologic studies suggest that parenchymal brain and spinal cord lesions in neurosarcoidosis occur when leptomeningeal-based granulomatous inflammation (which can be present histopathologically even in the absence of clinical symptoms) 35 spreads in a perivascular distribution along smalland medium-sized vessels. 5,[36][37][38] Our finding that medullary enhancement in SAM was always contiguous with the surface of the spinal cord supports this theory. Of interest, the spinal meningeal lymphatics are thought to be predominantly dorsally situated, 3,39 where the BSCB is also thought to be most permeable 10 and where subpial enhancement is most frequent in SAM.…”

Sarcoidosis of the central nervous system

“…The affinity of the sarcoid granuloma for cerebral vessels has been stressed by many authors (Longcope and Freiman, 1952;Meyer et al, 1953;Reske-Nielson et al, 1962;Robert, 1962;Urich, 1967) and was striking in the pathological material obtained from the cases reported here (Figs 2 and 5). This probably offers one explanation for the variable response to corticosteroid therapy.…”

“…This probably offers one explanation for the variable response to corticosteroid therapy. Areas of cerebral ischaemia and infarction have been described in relation to granulomatous cerebral angiitis (Meyer et al, 1953) and were found in case J.S. in this series.…”

Intrahepatic granulomatous arteriopathy

“…The lesions in this case do indeed bear some resemblance to those occasionally seen in sarcoidosis (Erickson, Osom & Stern, 1948;Meyer, Foley & Campagna-Pinto, 1953). In the reported cases of sarcoid vasculitis, however, the granulomata have been basically parenchymal and vascular involvement has been an accidental result of enlargement of the granulomata, either arteries or veins being involved in an indiscriminate manner.…”

Clinical and MRI phenotypes of sarcoidosis-associated myelopathy

“…Indeed, pathologic studies suggest that parenchymal brain and spinal cord lesions in neurosarcoidosis occur when leptomeningeal-based granulomatous inflammation (which can be present histopathologically even in the absence of clinical symptoms) 35 spreads in a perivascular distribution along smalland medium-sized vessels. 5,[36][37][38] Our finding that medullary enhancement in SAM was always contiguous with the surface of the spinal cord supports this theory. Of interest, the spinal meningeal lymphatics are thought to be predominantly dorsally situated, 3,39 where the BSCB is also thought to be most permeable 10 and where subpial enhancement is most frequent in SAM.…”

Sarcoidosis of the central nervous system

“…The affinity of the sarcoid granuloma for cerebral vessels has been stressed by many authors (Longcope and Freiman, 1952;Meyer et al, 1953;Reske-Nielson et al, 1962;Robert, 1962;Urich, 1967) and was striking in the pathological material obtained from the cases reported here (Figs 2 and 5). This probably offers one explanation for the variable response to corticosteroid therapy.…”

“…This probably offers one explanation for the variable response to corticosteroid therapy. Areas of cerebral ischaemia and infarction have been described in relation to granulomatous cerebral angiitis (Meyer et al, 1953) and were found in case J.S. in this series.…”