Granulomatosis With Polyangiitis Accompanied by Manifestations of Ovarian and Cervical Lesions

Granulomatosis with Polyangiitis-Mimicking Advanced Gynecological Cancer: A Case Report and Systematic Review of the Literature

“…Our systematic review identified 19 patients with GPA and genital tract involvement [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. Among them 11/19 (58%) had primary disease, and 8/19 (42%) had recurrence.…”

“…Once studies with patients with MPA or EGPA (5) were removed, a total of 17 studies fulfilled all inclusion criteria and were selected for full-text evaluation and systematic review [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. After reviewing the 17 articles, 18 patients were identified as GPA with gynecological involvement (two patients reported by Stone et al) [12].…”

“…The results are shown in Tables 1 and 2. In thirteen of the 19 patients (68%) [14][15][16][17][18][20][21][22][24][25][26][27][28],including our case, the authors considered gynecologic cancer as the first possibility of diagnosis. Among them, 11 (58%) thought they were dealing with cervical cancer [14][15][16][17][18]21,22,[24][25][26][27][28].…”

“…In thirteen of the 19 patients (68%) [14][15][16][17][18][20][21][22][24][25][26][27][28],including our case, the authors considered gynecologic cancer as the first possibility of diagnosis. Among them, 11 (58%) thought they were dealing with cervical cancer [14][15][16][17][18]21,22,[24][25][26][27][28]. Isolated genital involvement and multi-site involvement were present in 10 and in 9 out of 19 patients, respectively (43%).…”

Granulomatosis with polyangiitis complicated by genital involvement: sustained response to rituximab

“…Genital tract involvement in GPA while unusual has been reported in the literature, [1][2][3][4][5][6] with most published cases showing varying responses to cyclophosphamide. A case reported by Bastone et al demonstrates near resolution of disease at 20 months post commencement of rituximab therapy.…”