Granuloma Annulare

A Variant of Rheumatoid Arthritis resembling Palindromic Rheumatism

“…All our cases showed true rheumatoid nodules; they could be distinguished (but with some difficulty) from the rare subcutaneous nodule (see Gray, 1914;Goldschmidt, 1925;Grauer, 1934), ofgranuloma annulare, as seen in the four cases of that condition that we have biopsied. The nodules of necrobiosis lipoidica diabeticorum also resemble closely the lesions of granuloma annulare, as Ellis and Kirby Smith have shown: since 10 per cent.…”

Subcutaneous Granuloma Annulare

“…1,2,4,5,20 While there is no such association in the cutaneous lesions, Jacobi demonstrated a relationship in the subcutaneous lesions, where he found the remnants of large blood vessels in necrotic areas. According to his theory, the endovascular and peri-vascular changes result in complete oblit¬ Vascular insufficiency apparently plays a paramount role in the production of necro¬ biosis, and similar vascular changes occur in both cutaneous and subcutaneous granu¬ loma annulare as further evidence that they are parts of the same disease process.…”