Granulocyte-macrophage colony-stimulating factor in the management of severe ecthyma gangrenosum related to myelodysplastic syndrome

Non-pseudomonal Ecthyma Gangrenosum and Idiopathic Myelofibrosis in a Two-Year-Old Girl

“…Our patient also showed a good response to appropriate antibiotics. In a similar case study of an adult patient with myelofibrosis and persistent lesions of EG for about four weeks, granulocyte-macrophage colony stimulating factor (GM-CSF) was successfully used in the treatment regimen [ 3 ]. This indicates that supportive therapies to correct cytopenias can also be used for better outcomes.…”

“…There is ample evidence that it may occur secondary to other organisms as well, even occurring in the absence of bacteremia [ 1 ]. Immunocompromised children, such as those with leukemia, are often affected by it; in adults, the condition has also been linked to myelofibrosis [ 2 - 3 ]. Myelofibrosis, a disorder of hematopoietic stem cells, seen rarely in the pediatric population, is characterized by poor proliferation of one or more: myeloid lineage markers, reactive fibrosis of the bone, and extramedullary hematopoiesis.…”