Granular cell ameloblastoma

Martin, Yakob; Sathyakumar, M; Premkumar, Jeyanthi; Magesh, Karupur Thiagarajan

doi:10.4103/jomfp.jomfp_45_15

Cited by 8 publications

(8 citation statements)

References 9 publications

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“…Easier and more immediate is the differential diagnosis with entities such as Granular Cell Ameloblastoma (GCA) and Granular Cell Basal Cell Carcinoma (GCBCC) which have very distinct morphological characteristics, and which, even when the granular cells should represent the greatest part of the lesion, allow to detect a certain percentage of typical neoplasm that helps the pathologist to make the correct diagnosis. [9][10][11][12][13]…”

Section: Discussionmentioning

confidence: 99%

Granular cell dermatofibroma: A potential diagnostic pitfall

et al. 2022

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Dermatofibroma, also known as “fibrous histiocytoma”, is one of the most common cutaneous soft-tissue tumours. Many variants of dermatofibromas have been described and knowledge of these variations is important to avoid a misdiagnosis of a possibly more aggressive tumour. Histological features of different variants can coexist in the same lesion, but typical common fibrous histiocytoma features are generally found, at least focally, in all cases. However, when cellular changes make up the majority of the lesion, the histopathological diagnosis can become more complex and requires immunohistochemical investigations for a correct nosographic classification. We report on the case of a cutaneous fibrous histiocytoma, "granular cell" variant, found on the left leg of a 74 years old woman.

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Section: Discussionmentioning

confidence: 99%

Granular cell dermatofibroma: A potential diagnostic pitfall

et al. 2022

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“…The latter are due to an increased number of secondary lysosomes and maintain the same histiocyte cellular lineage [5]. Different theories [5,6] have been proposed to explain the mechanisms underlying lysosomal aggregation within the cytoplasm of these cells. It would appear that this process is caused by the dysfunction of a lysosomal enzyme or a lysosomal-associated protein involved in enzyme activation, rather than enzymatic targeting or lysosomal biogenesis [5,6].…”

Section: Discussionmentioning

confidence: 99%

“…Different theories [5,6] have been proposed to explain the mechanisms underlying lysosomal aggregation within the cytoplasm of these cells. It would appear that this process is caused by the dysfunction of a lysosomal enzyme or a lysosomal-associated protein involved in enzyme activation, rather than enzymatic targeting or lysosomal biogenesis [5,6]. These cytoplasmic changes are a constant features of granular cell tumors.…”

Section: Discussionmentioning

confidence: 99%

Granular Cell Dermatofibroma: When Morphology Still Matters

et al. 2021

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Dermatofibroma, also known as “fibrous histiocytoma”, is one of the most common cutaneous soft-tissue tumors. Many variants of dermatofibromas have been described, and knowledge of these variations is important to avoid misdiagnosis of a possibly more aggressive tumor. Histological features of different variants can coexist in the same lesion, but typical common fibrous histiocytoma features are generally found, at least focally, in all cases. However, when cellular changes make up the majority of the lesion, the histopathological diagnosis can become more complex and requires immunohistochemical investigations for correct nosographic classification. We present the case of a cutaneous fibrous histiocytoma, “granular cell” variant, found on the left leg of a 74-year-old woman.

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“…Six histopathologic subtypes of ameloblastoma are recognized: Follicular, acanthomatous, granular cell, basal cell, desmoplastic, and plexiform. Granular cell ameloblastomas are uncommon lesions accounting for about 3-5% of all histologic subtypes of ameloblastoma [1][2][3]. Granular cell ameloblastoma is diagnosed by the presence of granular cells, which typically occur within the central area of the tumor and progressively replace the stellate reticulum [1].…”

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confidence: 99%

Granular cell ameloblastoma: A rare and unique variant

Saxena

Somanathan

Anitha

2022

Indian J Case Reports

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Ameloblastoma is a slow-growing and locally invasive epithelial odontogenic tumor of the jaw that runs a benign course in most cases. Granular cell ameloblastoma is a rare subtype of ameloblastoma, showing the granular transformation of its cytoplasm. It is considered as an aggressive variant of ameloblastoma. Herein, we report the case of a 34-year-old male patient who presented with a swelling in the left cheek for a 1-year duration with a recent rapid increase in size. Examination showed a 4 × 3 cm growth involving the left buccal mucosa and retromolar area. Imaging studies showed expansile lytic lesion mandible. Biopsy revealed neoplasm with odontogenic epithelial islands showing peripheral palisading of tall columnar cells with reversal of polarity and the center of the islands showing stellate reticulum-like cells which were markedly replaced by granular cells. Granular cells can appear in various odontogenic and non- odontogenic tumors. When there is extensive granular cell change in ameloblastoma, it should be differentiated from other oral lesions with granular cells including granular cell odontogenic tumor, granular cell tumor, and congenital epulis.Herein we report the case of a 34-year-old male patient presented with swelling left cheek of one-year duration with recent rapid increase in size. Examination showed a 4x3 cm growth involving left buccal mucosa and retromolar area. Imaging studies showed expansile lytic lesion mandible. Biopsy revealed neoplasm with odontogenic epithelial islands showing peripheral palisading of tall columnar cells with reversal of polarity and the center of the islands showing stellate reticulum like cells which were markedly replaced by granular cells. Granular cells can appear in various odontogenic and nonodontogenic tumors. When there is extensive granular cell change in ameloblastoma it should be differentiated from other oral lesions with granular cells including granular cell odontogenic tumour, granular cell tumour and congenital epulis.

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Granular cell ameloblastoma

Cited by 8 publications

References 9 publications

Granular cell dermatofibroma: A potential diagnostic pitfall

Granular cell dermatofibroma: A potential diagnostic pitfall

Granular Cell Dermatofibroma: When Morphology Still Matters

Granular cell ameloblastoma: A rare and unique variant

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