Grammar improvement following deep brain stimulation of the subthalamic and the pedunculopontine nuclei in advanced Parkinson's disease: A pilot study

Zanini, Sergio; Moschella, Vincenzo; Peppe, Antonella; Pierantozzi, Mariangela; Galati, Salvatore; Costa, Alberto; Mazzone, Paolo; Stanzione, Paolo

doi:10.1016/j.parkreldis.2008.12.003

Cited by 44 publications

(38 citation statements)

References 11 publications

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“…Some linguistic functions improved, whereas some others deteriorated with STN stimulation. These contradictory results were also found in word generation studies (Castner et al, 2008;Silveri et al, 2012) and studies examining syntactic functions (Homer, Rubin, Horowitz, & Richter, 2012;Zanini et al, 2003Zanini et al, , 2009.…”

Section: Introductionmentioning

confidence: 83%

Subthalamic nucleus stimulation and spontaneous language production in Parkinson’s disease: A double laterality problem

et al. 2015

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Section: Introductionmentioning

confidence: 83%

Subthalamic nucleus stimulation and spontaneous language production in Parkinson’s disease: A double laterality problem

et al. 2015

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“…A careful review of the available literature on mammalian PPN suggests that the nucleus is a heterogeneous structure devoted to [ ( _ ) T D $ F I G ] not just motor functions [15][16][17]. For instance, specific subportions might be involved in the modulation of spinal cord excitability [12], whereas others likely affect sleep, associative domains, or even reward [12,[29][30][31]. Our data show that compared with the Off DBS condition, On PPTg DBS and On STN DBS increased of mean walking velocity.…”

Section: Discussionmentioning

confidence: 99%

“…Likewise, the percentage improvement of extrapyramidal symptoms, in particular, gait and balance (items [27][28][29][30], was better when STN and both stimuli were On (see Table 1). …”

Section: Comparisons Between Conditions In Pdmentioning

confidence: 99%

Deep brain stimulation of the pedunculopontine tegmentum and subthalamic nucleus: Effects on gait in Parkinson's disease

et al. 2010

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“…In addition, these patients experienced significant amelioration in cognitive functions as shown by a better performance in delayed recall, executive functions and verbal fluency paradigms. These improvements were accompanied by increased glucose utilization in prefrontal and frontal cortical areas bilaterally and in the ventral striatum [191][192][193].…”

Section: Resultsmentioning

confidence: 97%

Participation of the pedunculopontine tegmental nucleus in arousal-demanding functions

Vitale¹,

Capozzo²,

Mazzone³

et al. 2017

Transl Brain Rhythmicity

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The pedunculopontine tegmental nucleus (PPTg) is part of the locomotor mesencephalic region and the reticular activating system (RAS). As such, it is involved in regulating some aspects of the motor control and the wake/sleep cycle, but the way in which it operates is unclear. PPTg neurons respond to a variety of sensory stimuli and to cues that trigger the execution of goal-directed motor acts. In this paper, we discuss data that suggest that in addition to operating via thalamic nuclei, the PPTg may also operate by activating cerebellar nuclei, especially the dentate nucleus. In such a way, an intense and diffuse activation of the cerebral cortex may be achieved. In arousal-demanding reward-related tasks, separate populations of PPTg neurons modulate their discharge pattern to encode, in particular, expectancy and magnitude of reward. These neuronal responses, which should reach thalamic, basal ganglia, and cerebellar nuclei through ascending PPTg fibers are essential for the formation of stimuli-reward associations and action selection. In parallel, PPTg neurons, via descending fibers directed to lower brainstem and spinal motor structures, may automatically influence motor mechanisms and muscle tone in order to cause movements that are executed in a smooth and timely manner. In patients affected by Parkinson's disease, PPTg deep brain stimulation may increase arousal, thus making patients more attentive to behavioral stimuli that trigger motor act, while simultaneously facilitating movement.

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Grammar improvement following deep brain stimulation of the subthalamic and the pedunculopontine nuclei in advanced Parkinson's disease: A pilot study

Cited by 44 publications

References 11 publications

Subthalamic nucleus stimulation and spontaneous language production in Parkinson’s disease: A double laterality problem

Subthalamic nucleus stimulation and spontaneous language production in Parkinson’s disease: A double laterality problem

Deep brain stimulation of the pedunculopontine tegmentum and subthalamic nucleus: Effects on gait in Parkinson's disease

Participation of the pedunculopontine tegmental nucleus in arousal-demanding functions

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