Graft-vs-host reaction

Abstract

Observations surrounding the clinical manifestations and pathological studies of a neonate who died at 9 weeks of age, indicate that distinctive cutaneous, histopathologic, and ultrastructural findings occur when graft-vs-host reaction (GVHR) complicates combined immune deficiency syndrome (CIDS). The prominence and specificity of the epidermal lesions, particularly a necrotic cell that occurs in association with satellite lymphocytes ("satellite cell necrosis" (SCN)), lead us to recommend that a cutaneous biopsy be performed to facilitate an early definitive diagnosis. Dermatologists can recognize GVHR at the bedside and establish the diagnosis with the pathological findings obtained from the skin biopsy.

A distinctive eruption in patients receiving oxprenolol

“…There are some interesting similarities between the changes seen in our cases and those which have been described in the graft-versus-host reaction, in which lichen planus-like eruptions may occur (Saurat, 1975). In a recent description of a case occurring as a result of materno-fetal cell transfer, Grogan et al (1977) describe the presence of individual necrotic cells at different levels vvithin the epidermis, with focal areas of basal cell damage. A diffuse lymphocytic infiltrate was present in the papillary dermis, with some epidermal invasion.…”

Detection of maternal cells in human fetal blood during the third trimester of pregnancy using allele‐specific PCR amplification

“…These cells, incompletely matched with the histocompatibility antigens of the recipient, could contribute unacceptably to graftversus-host disease (GVHD). GVHD which had occurred in children with severe combined immunodeficiency (SCID) who had not undergone transplantation was the first evidence of the presence of maternal cells in neonatal blood (Grogan et al, 1985). Subsequently, maternal cells were detected by HLA-typing in children suffering from SCID without any GVHD (Pollack et al, 1982).…”

Ultrastructural Findings in Acute and Chronic Graft‐Vs‐Host Reaction of the Skin*

“…Only a few ultrastructural studies of cutaneous GVHR have been published (Claudy et al 1979, De Dobbeler et al 1975, Gallucci et al 1979, Grogan et al 1977, Woodruff et al 1972. In 1972, Woodruff et al referred to a detailed electron microscopic description of acute experimental GVHR in the Rhesus monkey.…”

“…This hypothesis is strongly supported by histopathologic observations of the skin, in which lymphocytes behaving as aggressor cells against epidermis can be observed. The observation of dying epidermal cells surrounded by aggressor lymphocytes has been emphasized by Woodruff et al (1972) in experimental GVHR and termed "satellite cell necrosis" by Grogan et al (1977).…”

“…Since patients with GVHR are relatively rare and since electron microscopic studies are even more scarce (Claudy et al 1979, De Dobbeler et al 1975, Gallucci et aL 1979, Grogan et al 1977, Woodruff et al 1972 we have considered it of interest to report the fine structural analysis of the skin in two patients with GVHR after allogeneic bone marrow transplantation. The clinical data, light microscopic histopathology and immunopathologic findings of these patients have been referred to previously (Mascaro et al 1980).…”