2021
DOI: 10.1038/s41598-020-79288-w
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Abstract: To analyze functional and anatomical response patterns to dexamethasone (DEX) implant in diabetic macular edema (DME), to describe proportion of responders and non-responders, and to propose a new DME grading system. Retrospective, multicenter, observational cohort study. Naïve and non-naïve DME patients were treated with DEX, with visual acuity (VA) ≥ 0.2 logMAR and central subfield thickness (CST) of ≥ 300 µm. Functional and anatomical responses were graded after 2 and 4 months, and categorized as early and … Show more

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Cited by 3 publications
(2 citation statements)
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“…Not surprisingly, anatomical outcomes followed functional outcomes and demonstrated a significant decrease from baseline and during the follow-up period. The inverse relation between CMT and BCVA has been described earlier 18,19 and should prompt a rapid retreatment when even slight edema recurs. 20 The decrease in CMT was similar between phakic and pseudophakic patients and showed around 40% of total edema reabsorption.…”
Section: Discussionmentioning
confidence: 66%
“…Not surprisingly, anatomical outcomes followed functional outcomes and demonstrated a significant decrease from baseline and during the follow-up period. The inverse relation between CMT and BCVA has been described earlier 18,19 and should prompt a rapid retreatment when even slight edema recurs. 20 The decrease in CMT was similar between phakic and pseudophakic patients and showed around 40% of total edema reabsorption.…”
Section: Discussionmentioning
confidence: 66%
“…Because of the anti-inflammatory properties [13] , corticosteroid therapy, including intravitreal triamcinolone and long-acting dexamethasone implants [14][15] , is an effective therapy for DME. As potent anti-inflammatory agents, corticosteroids are thought to counteract many of the pathological processes in the development of macular edema [16] .…”
Section: Discussionmentioning
confidence: 99%