Gradient cross-linked biodegradable polyelectrolyte nanocapsules for intracellular protein drug delivery

Dendrimer-like assemblies based on organoclays as multi-host system for sustained drug delivery

“…The resulting values were R 2 = 0.9067 and n = 0.3564, higher than R 2 = 0.90 and lower than n = 0.50, indicated that CP release from assemblies followed the diffusion controlled mechanism (Fickian diffusion) [39]. The diffusion involves three steps, i.e.…”

“…These silanol groups can bond covalently to a suitable substrate, especially inorganic solid surfaces displaying appropriate surface chemistries (such as -OH) [38], thus the free terminal amino groups can serve as attachment sites for b-CD [39]. So b-CD is conjugated as the host molecule that can complex with a guest drug to drive the self-assembly process.…”

Microspheres for Solid-Phase Modification of Proteins

“…Here, another example of hollow nanocapsule for protein loading is described. In order to improve loading efficiency and protein activity and reduce burst release, Shu et al (51) prepared gradient shell cross-linked hollow polyelectrolyte nanocapsules composed of cysteamine-conjugated chitosan and DS by layer-byDrug-Loading Methods layer adsorption on β-cyclodextrin (β-CD)-functionalized silica spheres followed by cross-linking thiols and removal of silica core, and the preparation process is shown in Fig. 9.26.…”

The Impact of Nanotechnology on Chitin and Chitosan Biomaterials Research

“…Li et al used a silica-based combination with β-cyclodextrin and chitosan to study the delivery of protein and peptide drugs through the GI tract [37]. Aminofunctionalized silica nanospheres were prepared from tetraethoxysilane (TEOS), 3-Aminopropyltriethoxysilane (APTES), and β-cyclodextrin (CD) via sequential 19 Excerpted from Yuan et al [35] with permission from Elsevier.…”