Grade 2 Chondrosarcoma: Stage I or Stage II Tumor?

Reith, John D.; Horodyski, Mary Beth; Scarborough, Mark T.

doi:10.1097/01.blo0000093895.12372.c1

Cited by 34 publications

(31 citation statements)

References 31 publications

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“…It grows slowly inside the medullary canal of a long bone for years before producing mild pain or a pathologic fracture [18,22,23]. A pathologic fracture usually is caused by a sudden progression of the local disease that is often a sign of transformation into high malignancy (dedifferentiation) [21].…”

Section: Introductionmentioning

confidence: 99%

“…Grading and staging are fundamental to establish the most appropriate type of surgery for CS [18]. Standard radiography often is sufficient to assess the extent of the tumor in the medullary canal and its relation with the cortex [5,9,14,15].…”

Section: Introductionmentioning

confidence: 99%

“…Although enchondroma can be treated by curettage, or in case of inactive lesions, even nonsurgically [6], Grade I CS usually is treated with en bloc resection with wide margins. The adequacy of intralesional surgery is advocated by some surgeons [2,13] and opposed by others [17][18][19]23].…”

Section: Introductionmentioning

confidence: 99%

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Surgical Treatment of Grade I Central Chondrosarcoma

Donati

Colangeli

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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The grade of chondrosarcoma relates to the likelihood of local recurrence and metastases. Many Grade I chondrosarcomas behave benignly if aggressively, and the question arises regarding whether wide resection is essential to control the disease. We therefore asked whether intralesional surgery also could be extended to Grade I chondrosarcomas without an increase in recurrence. We retrospectively reviewed 31 patients with Grade I chondrosarcomas of the limbs. The minimum followup was 66 months (mean, 157 months; range, 66-296 months

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Surgical Treatment of Grade I Central Chondrosarcoma

Donati

Colangeli

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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“…For lesions in expandable location, primary wide resection or amputation without biopsy may be indicated to decrease the chance of tumour contamination [11,12]. …”

Section: Discussionmentioning

confidence: 99%

Trans-articular chondrosarcoma grade 2 of proximal phalanx resulting in its fracture along with destruction of middle phalanx of 2nd toe right foot: a case report and review of the literature

Bashir

Gupta

Khan

et al. 2009

Cases J

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Foot is an unusual site for chondrosarcoma and involvement of phalanges is extremely rare. We report a case of grade 2 chondrosarcoma of proximal phalanx resulting in its fracture along with transarticular extension to the middle phalanx of the 2nd toe of right foot in a 62 year old female. The patient presented with 1 and ½ year history of pain and swelling in right 2nd toe. X-ray showed presence of expanding lytic lesion with amorphous calcification along with fracture proximal phalanx. Fine needle aspiration cytology showed some pleomorphs, osteoclasts and some giant cells. We went for amputation of toe without a biopsy. Histopathological examination of specimen showed multiple pleomorphic cells, nuclear atypia, hyperchromasia with some giant cells (grade 2 chondrosarcoma).

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“…Low-grade tumors typically are well differentiated, with moderate cellularity, and little pleomorphism or atypia. Other features such as host bone entrapement are more indicative of a malignant process [41,42,46,47]. The grading system progresses in degrees from low grade to high, depending on the appearance of the above characteristics.…”

Section: Histologymentioning

confidence: 98%

Chondrosarcoma of Bone

Leddy

Holmes

2014

Cancer Treatment and Research

111

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Chondrosarcoma is a cartilage forming neoplasm, which is the second most common primary malignancy of bone. Clinicians who treat chondrosarcoma patients must determine the grade of the tumor, and must ascertain the likelihood of metastasis. Acral lesions are unlikely to metastasize, regardless of grade, whereas axial, or more proximal lesions are much more likely to metastasize than tumors found in the distal extremities with equivalent histology. Chondrosarcoma is resistant to both chemotherapy and radiation, making wide local excision the only treatment. Local recurrence is frequently seen after intralesional excision, thus wide local excision is sometimes employed despite significant morbidity, even in low-grade lesions. Chondrosarcoma is difficult to treat. The surgeon must balance the risk of significant morbidity with the ability to minimize the chance of local recurrence and maximize the likelihood of long-term survival.

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Grade 2 Chondrosarcoma: Stage I or Stage II Tumor?

Cited by 34 publications

References 31 publications

Surgical Treatment of Grade I Central Chondrosarcoma

Surgical Treatment of Grade I Central Chondrosarcoma

Trans-articular chondrosarcoma grade 2 of proximal phalanx resulting in its fracture along with destruction of middle phalanx of 2nd toe right foot: a case report and review of the literature

Chondrosarcoma of Bone

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