2014
DOI: 10.1530/erc-14-0245
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Abstract: Elevated insulin levels have been associated with an increased cancer risk as well as with aggressive and metastatic cancer phenotypes characterized by a poor prognosis. Insulin stimulates the proliferation, migration, and invasiveness of cancer cells through diverse transduction pathways, including estrogen signaling. As G protein estrogen receptor 1

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Cited by 37 publications
(28 citation statements)
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References 56 publications
(79 reference statements)
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“…Further extending our previous findings [43], the present analysis showed a positive correlation between GPER and IGF1 expression in ER-negative BC patients. These data fit well with the capability of IGF1 to regulate GPER expression toward BC growth [28,43,76]. Moreover, in the current study, PDGFRB was demonstrated as an additional FA gene associated with GPER.…”
Section: Discussionsupporting
confidence: 88%
“…Further extending our previous findings [43], the present analysis showed a positive correlation between GPER and IGF1 expression in ER-negative BC patients. These data fit well with the capability of IGF1 to regulate GPER expression toward BC growth [28,43,76]. Moreover, in the current study, PDGFRB was demonstrated as an additional FA gene associated with GPER.…”
Section: Discussionsupporting
confidence: 88%
“…Consistent with these described survival effects, G-1 as well as ERĪ±- and ERĪ²-selective estrogenic ligands improved human islet-graft survival in a murine insulin-deficient xenotransplantation model; however, whereas all three ligands improved islet survival, only the ERĪ±- and ERĪ²-selective ligands improved islet revascularization [84]. Recent results also demonstrate the regulation of GPER expression by insulin [85] and insulin-like growth factor-I [86], as well as the GPER-mediated down regulation of miR-338-3p microRNA during pregnancy, enhancing both proliferation and survival under pro-apoptotic conditions [87], providing additional possible links between GPER, Ī²-cell survival and glucose metabolism.…”
Section: Gper and Glucose Homeostasismentioning
confidence: 72%
“…In ovariectomized female mice, the E2-mediated improvements in weight and fat reduction, glucose homeostasis, and adipocyte size were absent or mitigated in GPER knockout mice (Davis et al, 2014). The recent demonstration of the regulation of GPER expression by insulin suggests an additional potential linkage between GPER and metabolism (De Marco et al, 2014).…”
Section: B Endocrine/neuroendocrine Systemmentioning
confidence: 99%