Good Preclinical Bioanalytical Chemistry Requires Proper Sampling from Laboratory Animals: Automation of Blood and Microdialysis Sampling Improves the Productivity of LC/MSMS.

Xie, Fang; Bruntlett, Craig S.; Zhang, Yongxin; Kissinger, Candice B.; Kissinger, Peter T.

doi:10.2116/analsci.19.479

Cited by 15 publications

(15 citation statements)

References 11 publications

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“…A recent study demonstrated that this method can be used for the analysis of CBZ and CBZ-E in rat brain microdialysis samples [24]. The present study also describes the determination of CBZ and CBZ-E in rats following oral administration of CBZ in two different blood collection experiments.…”

Section: Introductionmentioning

confidence: 82%

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Liquid chromatography/tandem mass spectrometry for the determination of carbamazepine and its main metabolite in rat plasma utilizing an automated blood sampling system

Zhang

Chiang

Wulster-Radcliffe

et al. 2005

Journal of Pharmaceutical and Biomedical Analysis

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Section: Introductionmentioning

confidence: 82%

“…Therefore, automated blood sampling of conscious cannulated animals in a stress-free environment may result in more meaningful pharmacokinetic data. Automated blood sampling combined with LC/MS/MS also provide a mean to determine CBZ and CBZ-E in rat blood and rat brain microdialysate simultaneously [24].…”

Section: Introductionmentioning

confidence: 99%

Liquid chromatography/tandem mass spectrometry for the determination of carbamazepine and its main metabolite in rat plasma utilizing an automated blood sampling system

Zhang

Chiang

Wulster-Radcliffe

et al. 2005

Journal of Pharmaceutical and Biomedical Analysis

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“…As a reactive biological fl uid, blood and its fractions are fully amenable to liquid handling and fl uorogenic substrate probes for real-time monitoring of protease function [9][10][11][12] , including microarray reactions with nanoliter volumes [13][14][15] . This allows large data sets to be generated for a single blood sample [8] .…”

mentioning

confidence: 99%

Stochastic Modeling of Blood Coagulation Initiation

Denney

Diamond³

2005

Pathophysiol Haemos Thromb

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A kinetic Monte Carlo simulation was developed using the deterministic reaction network developed by the Mann laboratory for tissue-factor (TF)-initiated blood coagulation. The model predicted thrombin dynamics in recalcified whole blood (3-fold diluted) pretreated with convulxin (platelet GPVI activator) and picomolar levels of TF (0–14 pM). The model did not accurately predict coagulation times at low TF (0–0.7 pM). The simulation revealed that ∼0.2 pM TF was the critical concentration to cause 50% of reactions containing 3-fold diluted whole blood to reach a clotting threshold of 0.05 U/ml thrombin by 1 h. Simulations of 1 nl of blood (5 pM TF) revealed small stochastic variations in thrombin initiation time, while 16.6 pl simulations were highly stochastic at this level of TF (50 molecules/16.6 pl). Further experiment and simulation will require evaluation of mechanisms of coagulation kinetics at subpicomolar levels of TF.

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“…Therefore, catheterization of the duct near the hilum of the liver will allow the collection of pure bile (Fig. 7) [46,[58][59][60][61][62][63][64]. For bile duct cannulation, a midline abdominal incision of about 2 cm is made in an anaesthetized rat.…”

Section: Bile Samplingmentioning

confidence: 99%