Biochemical Pharmacology volume 79, issue 6, P801-809 2010 DOI: 10.1016/j.bcp.2009.10.004 View full text
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Heather A. Mitchell, David Weinshenker

Abstract: AbstractSleep is a crucial biological process is regulated through complex interactions between multiple brain regions and neuromodulators. As sleep disorders can have deleterious impacts on health and quality of life, a wide variety of pharmacotherapies have been developed to treat conditions of excessive wakefulness and excessive sleepiness. The neurotransmitter norepinephrine (NE), through its involvement in the ascending arousal system, impacts the efficacy of many wake-and sleeppromoting medications. Wak…

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