Gonadotrophins for idiopathic male factor subfertility

Is There a Role for Hormonal Therapy in Men with Oligoasthenoteratozoospermia (OAT)?

“…Therefore, the primary therapeutic role of gonadotropins is to increase sperm production in synergy with intratesticular testosterone. These agents are reported to have a significantly higher spontaneous pregnancy rate (16%) compared to controls (7%), as reported in a Cochrane review [14]. A meta-analysis by Santi et al analyzed 15 studies including 1275 men (half of the men treated with FSH and half of the men treated with placebo or untreated) and reported that FSH treatment provided significant increases in pregnancy rates spontaneously or with the use of assisted reproductive technology (ART) and an increase in sperm concentration in men with various severity of OAT [19].…”

Is There a Role for Hormonal Therapy in Men with Oligoasthenoteratozoospermia (OAT)?

“…Therefore, the primary therapeutic role of gonadotropins is to increase sperm production in synergy with intratesticular testosterone. These agents are reported to have a significantly higher spontaneous pregnancy rate (16%) compared to controls (7%), as reported in a Cochrane review [14]. A meta-analysis by Santi et al analyzed 15 studies including 1275 men (half of the men treated with FSH and half of the men treated with placebo or untreated) and reported that FSH treatment provided significant increases in pregnancy rates spontaneously or with the use of assisted reproductive technology (ART) and an increase in sperm concentration in men with various severity of OAT [19].…”

MECHANISMS IN ENDOCRINOLOGY: Hormonal regulation of spermatogenesis: mutant mice challenging old paradigms

“…Our findings may also explain why FSH has proven disappointing in the treatment of idiopathic oligozoospermia (35). The FSH doses have to be higher than the standard 75-150 IU every other day in order to improve spermatogenesis.…”

From Diagnosis to Treatment: Comprehensive Care by Reproductive Urologists in Assisted Reproductive Technology

“…A Cochrane Review revealed that the live pregnancy rate was significantly higher in treated men compared to the placebo or untreated group. The spontaneous pregnancy rate was also found to be higher in treated men [131].…”

Is There a Role for Hormonal Therapy in Men with Oligoasthenoteratozoospermia (OAT)?

“…Therefore, the primary therapeutic role of gonadotropins is to increase sperm production in synergy with intratesticular testosterone. These agents are reported to have a significantly higher spontaneous pregnancy rate (16%) compared to controls (7%), as reported in a Cochrane review [14]. A meta-analysis by Santi et al analyzed 15 studies including 1275 men (half of the men treated with FSH and half of the men treated with placebo or untreated) and reported that FSH treatment provided significant increases in pregnancy rates spontaneously or with the use of assisted reproductive technology (ART) and an increase in sperm concentration in men with various severity of OAT [19].…”

MECHANISMS IN ENDOCRINOLOGY: Hormonal regulation of spermatogenesis: mutant mice challenging old paradigms

“…Our findings may also explain why FSH has proven disappointing in the treatment of idiopathic oligozoospermia (35). The FSH doses have to be higher than the standard 75-150 IU every other day in order to improve spermatogenesis.…”

From Diagnosis to Treatment: Comprehensive Care by Reproductive Urologists in Assisted Reproductive Technology

“…A Cochrane Review revealed that the live pregnancy rate was significantly higher in treated men compared to the placebo or untreated group. The spontaneous pregnancy rate was also found to be higher in treated men [131].…”

Is There a Role for Hormonal Therapy in Men with Oligoasthenoteratozoospermia (OAT)?

“…Therefore, the primary therapeutic role of gonadotropins is to increase sperm production in synergy with intratesticular testosterone. These agents are reported to have a significantly higher spontaneous pregnancy rate (16%) compared to controls (7%), as reported in a Cochrane review [14]. A meta-analysis by Santi et al analyzed 15 studies including 1275 men (half of the men treated with FSH and half of the men treated with placebo or untreated) and reported that FSH treatment provided significant increases in pregnancy rates spontaneously or with the use of assisted reproductive technology (ART) and an increase in sperm concentration in men with various severity of OAT [19].…”

MECHANISMS IN ENDOCRINOLOGY: Hormonal regulation of spermatogenesis: mutant mice challenging old paradigms

“…Our findings may also explain why FSH has proven disappointing in the treatment of idiopathic oligozoospermia (35). The FSH doses have to be higher than the standard 75-150 IU every other day in order to improve spermatogenesis.…”

From Diagnosis to Treatment: Comprehensive Care by Reproductive Urologists in Assisted Reproductive Technology

“…A Cochrane Review revealed that the live pregnancy rate was significantly higher in treated men compared to the placebo or untreated group. The spontaneous pregnancy rate was also found to be higher in treated men [131].…”