Gold nanotubes: synthesis, properties and biomedical applications

Liu, Yanling; Zhu, Jingtao; Weng, Guo-jun; Li, Jianjun; Zhao, Jing

doi:10.1007/s00604-020-04460-y

Cited by 29 publications

(16 citation statements)

References 101 publications

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“…Au NCs contain various advantages such as low toxicity, good biocompatibility, stable luminescence, strong anti-bleaching capability and high stability. Therefore, they display great potential in the field of environmental detection, biomarker development, cell imaging and drug loading [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. Different protectants can be used to synthesize Au NCs (Figure…”

Section: Introductionmentioning

confidence: 99%

Nanotheranostic Application of Fluorescent Protein-Gold Nanocluster Hybrid Materials: A Mini-review

Ding¹,

Chen²

2021

Nanotheranostics

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The gold nanoclusters (Au NCs) are a special kind of gold nanomaterial containing several gold atoms. Because of their small size and large surface area, Au NCs possess macroscopic quantum tunneling and dielectric domain effects. Furthermore, Au NCs fluorescent materials have longer luminous time and better photobleaching resistance compared with other fluorescent materials. The synthetic process of traditional Au NCs is complicated. Traditional Au NCs are prepared mainly by using polyamide amine type dendrites, and sixteen alkyl trimethylamine bromide or sulfhydryl small molecule as stabilizers. They are consequently synthesized by the reduction of strong reducing agents such as sodium borohydride. Notably, these materials are toxic and environmental-unfriendly. Therefore, there is an urgent need to develop more effective methods for synthesizing Au NCs via a green approach. On the other hand, the self-assembly of protein gold cluster-based materials, and their biomedical applications have become research hotspots in this field. We have been working on the synthesis, assembly and application of protein conjugated gold clusters for a long time. In this review, the synthesis and assembly of protein-gold nanoclusters and their usage in cell imaging and other medical research are discussed.

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Section: Introductionmentioning

confidence: 99%

Nanotheranostic Application of Fluorescent Protein-Gold Nanocluster Hybrid Materials: A Mini-review

Ding¹,

Chen²

2021

Nanotheranostics

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“…63 Thus many applications of Au nanotubes have been used in biosensing, protein transportation, photothermal therapy, and imaging. 64 First, open-ended nanotubes have large inner voids considered as containers that can be filled with suitable drugs for targeted delivery in methods of chemotherapy. Second, compared to their spherical counterparts, the elongated nanotubes have extinction bands in the spectral range of transparency of hemoglobin that makes it possible to use them for laser photothermal therapy and hyperthermia of malignant cells.…”

Section: ■ Resultsmentioning

confidence: 99%

“…Au nanotubes offer new potential advantages that can be exploited in theranostic applications that integrate targeting, imaging, and therapy into one platform . Thus many applications of Au nanotubes have been used in biosensing, protein transportation, photothermal therapy, and imaging . First, open-ended nanotubes have large inner voids considered as containers that can be filled with suitable drugs for targeted delivery in methods of chemotherapy.…”

Section: Resultsmentioning

confidence: 99%

Plasmonic Enhancement of Local Fields in Ultrafine Metal Nanoparticles

et al. 2021

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We present an analysis of ultrafine metallic nanoparticles (1–15 nm) with respect to electromagnetic field generation by plasmonic excitations. A number of structures with different symmetries and geometries are studied in order to analyze the distributions of plasmonically generated near-electric fields and the concentration of hot and cold spots around the particles. The study is made possible by the recent development of an extended discrete interaction model (Ex-DIM) where the explicit dependency of the plasmonic spectra on the structure and composition of particles in the range of 1–15 nm is accounted for. With the Ex-DIM, the optical response of the internal crystal structure of the nanoscale particles can be visualized, thereby making it possible to predict the dependence of the generated local fields with respect to the position of the particles relative to the external field polarization. The results indicate rather surprising concentrations of the plasmon fields in very confined hot spots also in cases when the particles retain a high symmetry. The consequence of the findings of this study when using small symmetric nanoparticles for near-field imaging is briefly discussed.

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“…In the material selection process, it is also important to consider the suitability of the substrate material in terms of its stability in an environment or condition where it is to be applied. Each plasmonic metal exhibit their own characteristic properties that are not found in other metals; for example, gold is a biocompatible material but provides a lower signal enhancement than silver, which on the other hand is less stable due to it being prone to oxidation ( Liu et al, 2020 ). Studies have thus explored the use of both of these metals to take advantage of combining these properties, giving synergistic effects.…”

Section: Introductionmentioning

confidence: 99%

Challenges of SERS technology as a non-nucleic acid or -antigen detection method for SARS-CoV-2 virus and its variants

Sitjar

Liao

Lee

et al. 2021

Biosensors and Bioelectronics

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The COVID-19 pandemic has caused a significant burden since December 2019 that has negatively impacted the global economy owing to the fact that the SARS-CoV-2 virus is fast-transmitting and highly contagious. Efforts have been taken to minimize the impact through strict screening measures in country borders in order to isolate potential virus carriers. Effective fast-screening methods are thus needed to identify infected individuals. The standard diagnostic methods for screening SARS-CoV-2 virus have always been to perform nucleic acid-based and serological tests. However, with each having drawbacks on producing false results at very early or later stage after symptoms onset, supplementary techniques are needed to back up these tests. Surface-enhanced Raman spectroscopy (SERS) as a detection technique has continuously advanced throughout the years in terms of sensitivity and capability to detect ultralow concentration of analytes ranging from single molecule to pathogens, to present as a highly potential alternative to known sensing methods. SERS technology as a candidate for an alternative and supplementary diagnostic method for the viral envelope of SARS-CoV-2 virus is presented, comparing its pros and cons to the standard methods and what other aspects it could offer that the other methods are not capable of. Factors that contribute to the detection effectivity of SERS is also discussed to show the advantages and limitations of this technique. Despite its promising capabilities, challenges like sources of SARS-CoV-2 virus and its variations, reliable SERS spectra, mass production of SERS-active substrates, and compliance to regulations for wide-scale testing scenario are highlighted.

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Gold nanotubes: synthesis, properties and biomedical applications

Cited by 29 publications

References 101 publications

Nanotheranostic Application of Fluorescent Protein-Gold Nanocluster Hybrid Materials: A Mini-review

Nanotheranostic Application of Fluorescent Protein-Gold Nanocluster Hybrid Materials: A Mini-review

Plasmonic Enhancement of Local Fields in Ultrafine Metal Nanoparticles

Challenges of SERS technology as a non-nucleic acid or -antigen detection method for SARS-CoV-2 virus and its variants

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