Gold nanoparticles: role of size and surface chemistry on blood protein adsorption

Benetti, Filippo; Fedel, Mariangela; Minati, L.; Speranza, G.; Migliaresi, Claudio

doi:10.1007/s11051-013-1694-2

Cited by 29 publications

(23 citation statements)

References 16 publications

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“…14,15,34,[38][39][40][41] The size of quantum dots functionalized with dihydrolipoic acid or cysteamine increases after serum protein exposure and consequently prevents renal clearance. 21 The composition of the protein corona is influenced by many factors, including the duration of blood exposure, 7-9 the local environment, 7-9 as well as the physicochemical properties 7,18,23,24,[26][27][28][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57] of nanoparticles themselves. 39 Similarly, the formation of the protein corona on plasma treated silica and polystyrene beads show between 5 and 7-fold increased cell uptake, a major reduction in complement and coagulation pathway activation, and close to 40% increased cell viability.…”

Section: The Basis Of Protein Corona Formationmentioning

confidence: 99%

“…While material composition, 23,42 surface chemistry, 7,26,[43][44][45][46][47][48][49] and shape 24,50 have the most important effects on protein corona composition, 42 other physical properties such as the size, 20,24,25,35,39,41,42,60 radius of curvature, 11,18,23,[26][27][28][53][54][55] surface roughness, 57 and hydrophobicity 18,56,11 (Fig. While material composition, 23,42 surface chemistry, 7,26,[43][44][45][46][47][48][49] and shape 24,50 have the most important effects on protein corona composition, 42 othe...…”

Section: The Relationship Between the Synthetic And Biological Identimentioning

confidence: 99%

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Nanoparticle–blood interactions: the implications on solid tumour targeting

et al. 2015

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Nanoparticles are suitable platforms for cancer targeting and diagnostic applications. Typically, less than 10% of all systemically administered nanoparticles accumulate in the tumour. Here we explore the interactions of blood components with nanoparticles and describe how these interactions influence solid tumour targeting. In the blood, serum proteins adsorb onto nanoparticles to form a protein corona in a manner dependent on nanoparticle physicochemical properties. These serum proteins can block nanoparticle tumour targeting ligands from binding to tumour cell receptors. Additionally, serum proteins can also encourage nanoparticle uptake by macrophages, which decreases nanoparticle availability in the blood and limits tumour accumulation. The formation of this protein corona will also increase the nanoparticle hydrodynamic size or induce aggregation, which makes nanoparticles too large to enter into the tumour through pores of the leaky vessels, and prevents their deep penetration into tumours for cell targeting. Recent studies have focused on developing new chemical strategies to reduce or eliminate serum protein adsorption, and rescue the targeting potential of nanoparticles to tumour cells. An in-depth and complete understanding of nanoparticle-blood interactions is key to designing nanoparticles with optimal physicochemical properties with high tumour accumulation. The purpose of this review article is to describe how the protein corona alters the targeting of nanoparticles to solid tumours and explains current solutions to solve this problem.

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Section: The Basis Of Protein Corona Formationmentioning

confidence: 99%

Section: The Relationship Between the Synthetic And Biological Identimentioning

confidence: 99%

Nanoparticle–blood interactions: the implications on solid tumour targeting

et al. 2015

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“…[23]. The study of interactions between synthesized NPs and a biological environment is of primary importance [24]. Therefore, in this work, the effect of PEG on the downward tendency of protein adsorption was investigated by using static BSA protein adsorption test.…”

Section: Protein Adsorption Testmentioning

confidence: 99%

Synthesis of poly(ethylene glycol) (PEG) grafted silica nanoparticles with a minimum adhesion of proteins via one-pot one-step method

Akbari

Yegani

Pourabbas

2015

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…However, there is no universal theory that can be applied to all types of nanoparticles when exposed to human plasma [77]. Human plasma protein corona formation on metallic nanoparticles (i.e., gold and iron) has been reported [78,79].…”

Section: Human Blood Plasmamentioning

confidence: 99%

Silver nanoparticle protein corona and toxicity: a mini-review

Silveira¹,

Durán²,

Martinez³

2016

Nano Online

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(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Silver nanoparticles are one of the most important materials in the nanotechnology industry. Additionally, the protein corona is emerging as a key entity at the nanobiointerface; thus, a comprehensive understanding of the interactions between proteins and silver nanoparticles is imperative. Therefore, literature reporting studies involving both single molecule protein coronas (i.e., bovine and human serum albumin, tubulin, ubiquitin and hyaluronic-binding protein) and complex protein coronas (i.e., fetal bovine serum and yeast extract proteins) were selected to demonstrate the effects of protein coronas on silver nanoparticle cytotoxicity and antimicrobial activity.There is evidence that distinct and differential protein components may yield a "protein corona signature" that is related to the size and/or surface curvature of the silver nanoparticles. Therefore, the formation of silver nanoparticle protein coronas together with the biological response to these coronas (i.e., oxidative stress, inflammation and cytotoxicity) as well as other cellular biophysicochemical mechanisms (i.e., endocytosis, biotransformation and biodistribution) will be important for nanomedicine and nanotoxicology. Researchers may benefit from the information contained herein to improve biotechnological applications of silver nanoparticles and to address related safety concerns. In summary, the main aim of this mini-review is to highlight the relationship between the formation of silver nanoparticle protein coronas and toxicity. Keywords: Silver nanoparticles ; Protein corona; Cytotoxicity BackgroundRecently, silver nanoparticles have received a great deal of attention because of their distinctive physicochemical and biological properties. This interest originated with the use of silver nanoparticles in many different products because of their exceptionally small size and their potential antibacterial effect [1][2][3]. Currently, silver nanoparticles are primarily used for catalysis, transport, sensing and many other biological and medical applications [4,5]. However, these applications have increased the possibility of living organisms being directly or indirectly exposed to silver nanoparticles, which could induce numerous deleterious effects on human health and the environment. The adverse effects (primary or secondary) of silver nanoparticles on organs can extend into the cardiovascular or central nervous system, thereby causing neurotoxicity or immunotoxicity [6,7]. Important aspects of interactions between silver nanoparticle and cellular systemsThe cytotoxicity and genotox...

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Gold nanoparticles: role of size and surface chemistry on blood protein adsorption

Cited by 29 publications

References 16 publications

Nanoparticle–blood interactions: the implications on solid tumour targeting

Nanoparticle–blood interactions: the implications on solid tumour targeting

Synthesis of poly(ethylene glycol) (PEG) grafted silica nanoparticles with a minimum adhesion of proteins via one-pot one-step method

Silver nanoparticle protein corona and toxicity: a mini-review

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