2015
DOI: 10.2217/nnm.14.169
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Abstract: Photoacoustic (PA) imaging is a biomedical imaging modality that provides functional information regarding the cellular and molecular signatures of tissue by using endogenous and exogenous contrast agents. There has been tremendous effort devoted to the development of PA imaging agents, and gold nanoparticles as exogenous contrast agents have great potential for PA imaging due to their inherent and geometrically induced optical properties. The gold-based nanoparticles that are most commonly employed for PA ima… Show more

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Cited by 489 publications
(381 citation statements)
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“…Indeed, these properties have been utilized to develop AuNPs as contrast agents for the photoacoustic imaging. 72 Recently, an amphiphilic GNR coated with PEG and poly(lactic-coglycolic acid) (PLGA; AuNR⋅PEG⋅PLGA) was developed for the photoacoustic imaging in xenografted mice. 73 The AuNR⋅PEG⋅PLGA could self-assemble into vesicles with the AuNRs embedded in the shell formed by the PLGA and PEG extending into the aqueous environments to stabilize the structure.…”
mentioning
confidence: 99%
“…Indeed, these properties have been utilized to develop AuNPs as contrast agents for the photoacoustic imaging. 72 Recently, an amphiphilic GNR coated with PEG and poly(lactic-coglycolic acid) (PLGA; AuNR⋅PEG⋅PLGA) was developed for the photoacoustic imaging in xenografted mice. 73 The AuNR⋅PEG⋅PLGA could self-assemble into vesicles with the AuNRs embedded in the shell formed by the PLGA and PEG extending into the aqueous environments to stabilize the structure.…”
mentioning
confidence: 99%
“…However, the customisable structure and composition of nanomaterials have motivated their status as perhaps the most 'engineerable' platforms for PAI, particularly for integrating photoacoustic imaging with MRI, OI and therapeutic strategies. Recent years have witnessed the successful application of approaches involving metal-based (nanoparticles, nanorods, nanoshells and nanocages) and carbon-based (carbon dots, nanotubes, nanopolymers and nanovesicles) nanomaterials for targeting cell-specific antigens or the microenvironment (pH, pO2 sensing), or for passive targeting (that is, by taking advantage of the enhanced permeability and retention effect) in PAI 94,[99][100][101][102][103][104][105][106] . Although PAI is limited by tissue-penetration depth of the requisite excitation light, its clinical outlook is terrific for the early detection and monitoring of superficial or near-surface lesions, as well as those accessible via endoscopy.…”
Section: Paimentioning
confidence: 99%
“…Photoacoustic imaging is a hybridized technique combining non-ionizing radiation and ultrasonic detection [292,[370][371][372]. The photoacoustic signal is considered inherently weak due to the low intrinsic absorption of oxyhemoglobin and deoxyhemoglobin in the NIR [177,[373][374][375].…”
Section: Imagingmentioning
confidence: 99%