Gold Nanoparticle Self-Similar Chain Structure Organized by DNA Origami

Ding, Baoquan; Deng, Zhengtao; Yan, Hao; Cabrini, Stefano; Zuckermann, Ronald N.; Bokor, Jeffrey

doi:10.1021/ja9101198

Cited by 498 publications

(492 citation statements)

References 12 publications

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confidence: 99%

“…DNA origami, in particular, has proven useful for organizing nanoscale objects, such as biomolecules [7][8][9] , nanoelectronic or photonic components [10][11][12] , small molecules 13 and moving DNA machines [14][15][16] . While an individual origami can serve as a template for up to 200 small devices, typically only a single multi-component electronic or optical device is constructed 10,12 . For many technological applications it would be desirable to organize origami into periodic arrays, for example, to allow wiring of electronic devices together, to create cooperative optical effects as seen in optical metasurfaces 17 , to create DNA 'etch masks' 18,19 or to enable easier extraction of single-molecule biophysical data 9,20 .…”

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Self-assembly of two-dimensional DNA origami lattices using cation-controlled surface diffusion

2014

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DNA origami has proven useful for organizing diverse nanoscale components into patterns with 6 nm resolution. However for many applications, such as nanoelectronics, large-scale organization of origami into periodic lattices is desired. Here, we report the self-assembly of DNA origami rectangles into two-dimensional lattices based on stepwise control of surface diffusion, implemented by changing the concentrations of cations on the surface. Previous studies of DNA-mica binding identified the fractional surface density of divalent cationsñ s2 ð Þ as the parameter which best explains the behaviour of linear DNA on mica. We show that for n s2 between 0.04 and 0.1, over 90% of DNA rectangles were incorporated into lattices and that, compared with other functions of cation concentration,ñ s2 best captures the behaviour of DNA rectangles. This work shows how a physical understanding of DNA-mica binding can be used to guide studies of the higher-order assembly of DNA nanostructures, towards creating large-scale arrays of nanodevices for technology.

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Self-assembly of two-dimensional DNA origami lattices using cation-controlled surface diffusion

2014

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“…In this novel hybrid system graphene could be used as the electrical interconnect and as an e-beam tailored substrate, while origami can be used as template for material growth, 26,27 sensor, 28,29 or even as a template for specific single-molecule chemical reactions. 30 …”

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confidence: 99%

ssDNA Binding Reveals the Atomic Structure of Graphene

et al. 2010

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We used AFM to investigate the interaction of polyelectrolytes such as ssDNA and dsDNA molecules with graphene as a substrate. Graphene is an appropriate substrate due to its planarity, relatively large surfaces that are detectable via an optical microscope, and straightforward identification of the number of layers. We observe that in the absence of the screening ions deposited ssDNA will bind only to the graphene and not to the SiO 2 substrate, confirming that the binding energy is mainly due to the π-π stacking interaction. Furthermore, deposited ssDNA will map the graphene underlying structure. We also quantify the π-π stacking interaction by correlating the amount of deposited DNA with the graphene layer thickness. Our findings agree with reported electrostatic force microscopy (EFM) measurements. Finally, we inspected the suitability of using a graphene as a substrate for DNA origami-based nanostructures.

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“…The strength of this technique has been demonstrated in a number of applications including control and study of molecular transport in cells [8][9][10] , drug delivery systems 11 , as platforms for single-molecule chemical reactions 12,13 , rulers for super-resolution microscopy 14,15 as well as nanopore biosensors [16][17][18] . Furthermore, the double helical structure of DNA offers the possibility of unique binding sites with a regular spacing of B7 nm (21 bp) along the helix and B3 nm perpendicular to the helical axis 19 which makes DNA origami perfectly suited as a platform for the assembly of multicomponent nanostructures 20,21 .…”

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DNA origami based assembly of gold nanoparticle dimers for surface-enhanced Raman scattering

et al. 2014

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Plasmonic sensors are extremely promising candidates for label-free single-molecule analysis but require exquisite control over the physical arrangement of metallic nanostructures. Here we employ self-assembly based on the DNA origami technique for accurate positioning of individual gold nanoparticles. Our innovative design leads to strong plasmonic coupling between two 40 nm gold nanoparticles reproducibly held with gaps of 3.3±1 nm. This is confirmed through far field scattering measurements on individual dimers which reveal a significant red shift in the plasmonic resonance peaks, consistent with the high dielectric environment due to the surrounding DNA. We use surface-enhanced Raman scattering (SERS) to demonstrate local field enhancements of several orders of magnitude through detection of a small number of dye molecules as well as short single-stranded DNA oligonucleotides. This demonstrates that DNA origami is a powerful tool for the high-yield creation of SERS-active nanoparticle assemblies with reliable sub-5 nm gap sizes.

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Gold Nanoparticle Self-Similar Chain Structure Organized by DNA Origami

Cited by 498 publications

References 12 publications

Self-assembly of two-dimensional DNA origami lattices using cation-controlled surface diffusion

Self-assembly of two-dimensional DNA origami lattices using cation-controlled surface diffusion

ssDNA Binding Reveals the Atomic Structure of Graphene

DNA origami based assembly of gold nanoparticle dimers for surface-enhanced Raman scattering

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