Gold Nanoparticle‐Based Electrochemical Biosensors for Medical Applications

Anık, Ülkü

doi:10.1002/9781118523025.ch8

Cited by 4 publications

(1 citation statement)

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“…Recent advances in unique properties of nanomaterials have heightened interest in their employment in biosensing sectors, resulting in substantial advancement in the fabrication of nanomaterial-based biosensors. The use of nanostructured materials to organize electrochemical sensing devices has a lot of appeal since they provide an electro-catalytic effect as well as a higher surface area, which is important for enzyme immobilization in electrochemical biosensors [ 64 , 65 ]. Early cancer detection, on the other hand, is crucial for patient survival and effective disease therapy, which demands delicate and specialized methods.…”

Section: Role Of Zno Nps In Diagnosis Of Cancermentioning

confidence: 99%

Recent Advances in Zinc Oxide Nanoparticles (ZnO NPs) for Cancer Diagnosis, Target Drug Delivery, and Treatment

Anjum

Hashim

Malik

et al. 2021

Cancers

246

102

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Cancer is regarded as one of the most deadly and mirthless diseases and it develops due to the uncontrolled proliferation of cells. To date, varieties of traditional medications and chemotherapies have been utilized to fight tumors. However, their immense drawbacks, such as reduced bioavailability, insufficient supply, and significant adverse effects, make their use limited. Nanotechnology has evolved rapidly in recent years and offers a wide spectrum of applications in the healthcare sectors. Nanoscale materials offer strong potential for curing cancer as they pose low risk and fewer complications. Several metal oxide NPs are being developed to diagnose or treat malignancies, but zinc oxide nanoparticles (ZnO NPs) have remarkably demonstrated their potential in the diagnosis and treatment of various types of cancers due to their biocompatibility, biodegradability, and unique physico-chemical attributes. ZnO NPs showed cancer cell specific toxicity via generation of reactive oxygen species and destruction of mitochondrial membrane potential, which leads to the activation of caspase cascades followed by apoptosis of cancerous cells. ZnO NPs have also been used as an effective carrier for targeted and sustained delivery of various plant bioactive and chemotherapeutic anticancerous drugs into tumor cells. In this review, at first we have discussed the role of ZnO NPs in diagnosis and bio-imaging of cancer cells. Secondly, we have extensively reviewed the capability of ZnO NPs as carriers of anticancerous drugs for targeted drug delivery into tumor cells, with a special focus on surface functionalization, drug-loading mechanism, and stimuli-responsive controlled release of drugs. Finally, we have critically discussed the anticancerous activity of ZnO NPs on different types of cancers along with their mode of actions. Furthermore, this review also highlights the limitations and future prospects of ZnO NPs in cancer theranostic.

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Section: Role Of Zno Nps In Diagnosis Of Cancermentioning

confidence: 99%