Gold dermatitis. A clinical and histopathological study

Penneys, Neal S.

doi:10.1001/archderm.109.3.372

Cited by 67 publications

(26 citation statements)

References 10 publications

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“…associated with a hyperplastic granular layer leads most probably to a diagnosis of ILP. Contrary to many other types of drug eruptions, it has to be noted that eosinophils are seen infrequently in LDE ( [10][11][12] and our study), whilst they are absent in ILP.…”

Section: Discussioncontrasting

confidence: 61%

Histopathological Discriminant Criteria between Lichenoid Drug Eruption and Idiopathic Lichen planus: Retrospective Study on Selected Samples

Haute¹,

Antoine²,

Lachapelle³

1989

Dermatology

122

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The lesions observed in 15 idiopathic lichen planus (ILP) skin biopsies were compared with those occurring in 15 clinically relevant lichenoid drug eruptions (LDE). Various histopathological features were taken into account. Statistical analysis of results showed that none of these can be considered as a significant criterium allowing a pathognomonic differential diagnosis between ILP and LDE. Nevertheless, a strong suggestion of drug etiology can be inferred when the following histopathological signs (‘LDE-related criteria’) are present: focal parakeratosis, focal interruption of the granular layer, cytoid bodies in the cornified and granular layers, present in more than 50% of LDE and never in ILP

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Section: Discussioncontrasting

confidence: 61%

Histopathological Discriminant Criteria between Lichenoid Drug Eruption and Idiopathic Lichen planus: Retrospective Study on Selected Samples

Haute¹,

Antoine²,

Lachapelle³

1989

Dermatology

122

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“…Patient LM developed a biopsy proven lichen planus-like gold dermatitis shortly after reaching a cumulative dose of 460 mg Myochrysine. Histologic features of the eruption have been published elsewhere (5). Biopsies taken from the skin lesions and from normal-appearing skin showed similar gold concentrations, the lesions having slightly greater gold levels.…”

Section: Resultsmentioning

confidence: 80%

Gold concentrations in hair, nail, and skin during chrysotherapy

Gottlieb

Smith

Penneys

et al. 1974

Arthritis & Rheumatism

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Serial hair and nail specimens were obtained from 18 patients with rheumatoid arthritis receiving chrysotherapy. Punch biopsies of skin lesions and normal-appearing skin from 4 other patients with gold dermatitis, and serial skin biopsies from 4 additional patients were obtained at intervals during chrysotherapy. Gold content was measured in these samples using neutron activation analysis. Small quantities of gold were found in hair (mean = 0.30 pg/g), nail (mean = 0.17 pg/g), and skin (mean = 0.03 pg/g) prior to chrysotherapy, with two-to fivefold increases after 3-12 months of treatment. Compared to those from patients who did not develop gold toxicity, gold concentrations in all three tissues were similar in patients who developed gold toxicity. Gold levels were identical in skin lesions and normal-appearing skin of patients with gold dermatitis. These findings indicate that gold has little affinity for keratinous tissues, and that determination of gold content in these tissues is not helpful in differentiating gold-toxic from nontoxic patients.Recent studies (1,2) have confirmed earlier reports (3) of the efficacy of gold compounds in the treatment of rheumatoid arthritis (RA). Although gold compounds

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“…The most common form of gold-induced dermatitis is non-allergic, since following clearance of the original eruption, patients can be restarted on gold treatment without developing further dermatitis. 43 In contrast, allergic contact dermatitis occurs at a lower incidence and represents an immune reactivity to gold which usually necessitates total cessation of gold therapy. 44 Diarrhea is also frequently associated with administration of gold complexes, but with a greater incidence when patients use oral gold preparations.…”

Section: Gold Toxicitymentioning

confidence: 99%

Gold Nanoparticles: A Revival in Precious Metal Administration to Patients

et al. 2011

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Gold has been used as a therapeutic agent to treat a wide variety of rheumatic diseases including psoriatic arthritis, juvenile arthritis and discoid lupus erythematosus. Although the use of gold has been largely superseded by newer drugs, gold nanoparticles are being used effectively in laboratory based clinical diagnostic methods whilst concurrently showing great promise in vivo either as a diagnostic imaging agent or a therapeutic agent. For these reasons, gold nanoparticles are therefore well placed to enter mainstream clinical practice in the near future. Hence, the present review summarizes the chemistry, pharmacokinetics, bio-distribution, metabolism and toxicity of bulk gold in humans based on decades of clinical observation and experiments in which gold was used to treat patients with rheumatoid arthritis. The beneficial attributes of gold nanoparticles, such as their ease of synthesis, functionalization and shape control are also highlighted demonstrating why gold nanoparticles are an attractive target for further development and optimization. The importance of controlling the size and shape of gold nanoparticles to minimize any potential toxic side effects is also discussed.

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Gold dermatitis. A clinical and histopathological study

Cited by 67 publications

References 10 publications

Histopathological Discriminant Criteria between Lichenoid Drug Eruption and Idiopathic Lichen planus: Retrospective Study on Selected Samples

Histopathological Discriminant Criteria between Lichenoid Drug Eruption and Idiopathic Lichen planus: Retrospective Study on Selected Samples

Gold concentrations in hair, nail, and skin during chrysotherapy

Gold Nanoparticles: A Revival in Precious Metal Administration to Patients

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