Gold: an allergen of growing significance

Hostýnek, Jurij J.

doi:10.1016/s0278-6915(97)00058-6

Cited by 33 publications

(30 citation statements)

References 48 publications

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“…It was recognised that gold ions are powerful inhibitors of macrophages and polymorphonuclear leucocytes. [67] Most reports are focused on the release of gold ions from implants and their accumulation in tissues and cells. [68] The immuno-modulatory effects of gold ions have been exploited in the treatment of rheumatic arthritis for more than 50 years.…”

Section: Discussionmentioning

confidence: 99%

Gold nanoparticles and ions – friends or foes? As they are seen by human cells U-937 and HL-60

Barbasz

Oćwieja

2015

Journal of Experimental Nanoscience

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Gold nanoparticles (AuN) are one of the most investigated nanomaterials, finding numerous applications from medicine to industry. AuN were obtained by reduction of gold salts using tannic acid as a reducing agent. To detach the impact of AuN onto cells of two lines human monocytic cells (U-937) and human promyelocytic leukaemia cells (HL-60), the effects of postreaction residues (of effluent from sol cleaning) and gold ions were also examined. It was demonstrated that resistance of cells to the toxic action of AuN is dependent not only on incubation time and dosage, but also on stages of cell differentiation. It was found that after incubation of promonocytes U-937 with 25 ppm AuN, the cell viability decreased by 25% and of macrophages by 50%. Differentiated cells U-937 showed a significantly lower resistance than the not-differentiated cells. For HL-60 cells, regardless of differentiation, cell viability decreased by approximately 20% after treatment with 25 ppm AuN sol. It was noticed that U-937 exhibited higher vulnerability to AuN than HL-60 cells. It was proved that AuN induced over a 15-fold increase in nitric oxide and a decrease of intracellular glutathione levels indicating the inflammatory response of cells. Even though gold ions did not show a significant effect on cell viability, they caused fivefold increase of nitric oxide level. The results show a higher cytotoxicity of AuN than gold ions. An overall picture of the interaction of AuN with human cells of first defence line was obtained. The results indicate that AuN may cause changes in the response of phagocytes in inflammatory conditions.

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Section: Discussionmentioning

confidence: 99%

Gold nanoparticles and ions – friends or foes? As they are seen by human cells U-937 and HL-60

Barbasz

Oćwieja

2015

Journal of Experimental Nanoscience

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“…Bei einer Patientin mit Kontaktekzem der Ohrläppchen wurden mit einer Mikro-Rönt-genanalyse noch vier Monate nach Entfernung der Ohrringe Goldspuren im Gewebe nachgewiesen (Suzuki 1998 Weitere, zumeist ältere Berichte über Sensibilisierung durch Gold bzw. Goldverbindungen sind in mehreren Übersichtsarbeiten zusammengefasst Bruze und Andersen 1999;Cronin 1980;Hostynek 1997;Isaksson und Bruze 2000;Rapson 1985). Einige Mitteilungen betreffen Patienten mit vermutlichen Unverträglichkeiten von Zahn(ersatz)materialien und Symptomen an Pharynx, Larynx oder Mundschleimhaut (Aro et al 1993;Fregert et al 1979;Kilpikari 1997;Klaschka 1975 Tvinnereim et al 2003;Schöpf et al 1970).…”

Section: Hautsensibilisierende Wirkungunclassified

Gold und seine anorganischen Verbindungen [MAK Value Documentation in German language, 2006]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 41. Lieferung, Ausgabe 2006 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Aufnahme, Verteilung, Ausscheidung Metabolismus Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Sonstige Wirkungen Bewertung

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“…Patients develop dermatitis, stomatitis, and eosinophilia, and less commonly immune-complex glomerulonephritis, lymphadenopathy, antinuclear antibody, increased serum IgE, hypogammaglobulinemia, and other blood disorders. Although this has led to a decline in the therapeutic use of Au salts in recent years, their history in the treatment of arthritis has given rise to a growing recognition of the importance of Au as a sensitizer [86]. Until recently, Au allergy was considered rare in the absence of its medical use.…”

Section: Goldmentioning

confidence: 99%

“…[84,88]. Various studies have reported positive patch test frequencies of between less than 1 % and greater than 10 %, but it has been proposed that many cases of type IV hypersensitivity to Au are asymptomatic, and the standard protocol of patch testing with gold sodium thiomalate may produce false negatives because a prolonged exposure may be necessary; a positive reaction may require three weeks or more [86]. Women account for the majority of positive subjects in most studies [84,88].…”

Section: Goldmentioning

confidence: 99%

Mechanisms of immunosensitization to metals (IUPAC Technical Report)

Templeton¹

2004

Pure and Applied Chemistry

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A project is underway within IUPAC to evaluate and harmonize the use of various biomarkers for immunosensitization to metals. This present review summarizes our knowledge of the mechanisms by which certain trace elements evoke allergenicity. Some physiological electrolytes (e.g., Na+, K+) and macronutrients (e.g., Ca2+, Fe3+) are immunologically inactive. However, some trace elements essential for cell function (e.g., Co2+, Cu2+, Cr3+), as well as nonessential elements generally considered toxic (e.g., Hg species) or in use as therapeutic agents (e.g., some species of Pt and Au), can give rise to adverse immune reactions. Specific immunological responses to Ni, Co, Cr, Hg, Be, Cu, Pt, Pd, Ir, In, and Au are discussed. In general, these elements can activate T or B cells by specific receptor interactions, resulting in clonal expansion of a metal-specific lymphocyte and an immune response (typically dermatitis) upon re-exposure. Compelling evidence points to the primary role of the T cell in responding to the metal. T-cell activation occurs when a protein of the major histocompatibility complex (MHC) binds to a T-cell receptor in the presence of an MHC binding peptide. Many antigenic substances result in presentation of MHC bound antigenic peptides to the T-cell receptor; metal ions appear to act as haptens that directly or indirectly cause structural changes in MHC molecule-peptide complexes that result in recognition of these complexes by specific T-cell subsets. Nickel and gold are particularly instructive in understanding mechanisms, and are used to discuss models in which the metal may bind to the antigenic peptide (i) before or (ii) after its association with the MHC/T-cell receptor complex, (iii) may bind to the MHC/receptor complex prior to recruitment of the antigenic peptide, or (iv) may bind to the formed peptide/MHC/receptor complex through ligands contributed by one or more of the components.

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Gold: an allergen of growing significance

Cited by 33 publications

References 48 publications

Gold nanoparticles and ions – friends or foes? As they are seen by human cells U-937 and HL-60

Gold nanoparticles and ions – friends or foes? As they are seen by human cells U-937 and HL-60

Gold und seine anorganischen Verbindungen [MAK Value Documentation in German language, 2006]

Mechanisms of immunosensitization to metals (IUPAC Technical Report)

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