Goiter and Impairment of Thyroid Function in Acromegalic Patients: Basal Evaluation and Follow-Up

Cannavò, Salvatore; Squadrito, S.; Finocchiaro, M; Curtò, Lorenzo; Almoto, B.; Vieni, A.; Trimarchi, Francesco

doi:10.1055/s-2007-978620

Cited by 33 publications

(36 citation statements)

References 9 publications

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“…These results were similar to those quoted by Maiarano et al, who denied the presence of a link between the demographic data and the tissue levels of IGF-1 in thyroidal cancer patients (20). Additionally, besides controversial data in the literature, we observed no relationship between the tissue levels of IGF-1 and the volumes of thyroid tissues or nodules (20,23).…”

Section: Discussionsupporting

confidence: 91%

The Role of Insulin-Like Growth Factor 1 in the Development of Benign and Malignant Thyroid Nodules

Baştürk¹,

Kement²,

Yavuzer³

et al. 2012

Balkan Med J

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Objective: This study aims to investigate the role of IGF-1 in the development of nodular thyroid disease. Material and Methods:A total number of 100 consecutive patients operated for nodular thyroid disease in our institution were included in this prospective study. In addition to classical pathological examinations, nodules and extranodular healthy tissues were sampled and immunochemically stained for IGF-1. The materials were independently evaluated using an Allred Scoring System ranging from 0 to 8. If the score was ≥1, the tissue was accepted as IGF-1 positive.Results: IGF-1 positivity was observed in 88% and 58% of the samples obtained from nodules and extranodular healthy tissues, respectively. Allred 8-unit scores were higher in benign nodules (n=89; 4.1±2.3) and papillary carcinomas (n=7; 6.7±1.3), than in extranodular healthy tissues in the same patients (2.3±2.3 and 3.3±1.9, respectively); and higher in papillary carcinomas than in benign nodules, when the scores were compared to each other (p<0.01 for all comparisons).Conclusions: Allred 8-unit scores for IGF-1 increase in the presence of benign thyroid nodules, papillary cancer. The results of our study support the findings of previous studies demonstrating the role of IGF-1 in the development of thyroidal nodules.

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Section: Discussionsupporting

confidence: 91%

The Role of Insulin-Like Growth Factor 1 in the Development of Benign and Malignant Thyroid Nodules

Baştürk¹,

Kement²,

Yavuzer³

et al. 2012

Balkan Med J

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“…Acromegalia e patologia tireoidiana A prevalência de distúrbios tireoidianos dentre acromegálicos é aumentada, de 18% a 92% (11)(12)(13)(14)(15), dependendo dos métodos de avaliação clínica (palpação tireoidiana ou ultrassonográfica) e da presença de deficiência de iodo. Com o uso da ultrassonografia, notase que a prevalência de bócio na acromegalia é alta, em torno de 80% (16), sendo que até 66,7% destes bócios são nodulares.…”

Section: Discussionunclassified

“…Doenças auto-imunes aparentemente não têm relação com a acromegalia. A literatura descreve uma relação positiva entre a duração da acromegalia e o tamanho do bócio, sem relação entre os níveis de TSH e o volume tireoidiano (11,(13)(14)(15)19). Já os níveis aumentados de IGF-I e GH parecem estar relacionados ao volume da glândula (11,13,14), embora isso não tenha sido confirmado em outros trabalhos (12,15).…”

Section: Discussionunclassified

Acromegalia e doença tiroideana: prevalência de câncer de tireóide

Marchisotti

Umeda

Zach

et al. 2005

Arq Bras Endocrinol Metab

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RESUMOA relação entre câncer e acromegalia tem sido objeto de estudo há muitos anos. A partir de um caso de carcinoma diferenciado de tireóide em um de nossos pacientes acromegálicos, estudamos uma série de 100 outros acromegálicos e encontramos dois outros casos de câncer de tireóide, descritos neste trabalho. A partir daí, levantamos os dados da literatura sobre esta última associação e sua possível patogênese. A prevalência de patologias tireoidianas é aumentada dentre os acromegálicos, às custas, principalmente, do bócio nodular. Esta associação será abordada, assim como a relação entre o fator de crescimento insulina símile I (IGF-I) e câncer, numa tentativa de entender melhor seu significado frente aos nossos casos. Nós concluímos que seria prudente realizar exame ultrassonográfico periódico em acromegálicos, seguido de Punção Aspirativa com Agulha Fina (PAAF) dos nódulos suspeitos. The relationship between cancer and acromegaly has been subject of study for many years. From a case of differentiated thyroid carcinoma in one of our acromegalic patients, we reviewed a series of 100 acromegalics and found two others cases of thyroid cancer, which are described in this work. From that point, we have got data from the literature about this last association and its possible pathogenesis. The prevalence of thyroid disease is increased among acromegalic patients, mainly due to nodular goiter. This association will be discussed, as well as the relation between insulin-like growth factor-I and cancer, in an effort to have a better understanding of its meaning for our cases. We concluded that it would be prudent to do periodic ultrasonografic evaluation of acromegalic patients, follow by fine needle aspiration biopsies of suspect nodules. UM LARGO ESPECTRO DE MANIFESTAÇÕES clínicas sistêmicas caracteriza a acromegalia. Bócio, pólipos colônicos, número aumentado de papilomas cutâneos (skin tags) e hiperidrose são geralmente descritas ao diagnóstico, juntamente com crescimento exagerado das mãos e pés, e características faciais grosseiras.Neoplasias malignas são consideradas, em conjunto com doenças

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“…The prevalence of diffuse or nodular goiter in acromegaly is dramatically high (up to 70-100% of patients, in different studies) and the risk of developing thyroid cancer is increased (up to 6%) in patients with active disease (11,12,13,14,15,16,17,18). IGF1 excess is implicated in the development of goiter, as sera of active and untreated acromegalic patients potentiate the proliferative effect of TSH on thyrocytes in vitro (19).…”

Section: Introductionmentioning

confidence: 99%

“…IGF1 excess is implicated in the development of goiter, as sera of active and untreated acromegalic patients potentiate the proliferative effect of TSH on thyrocytes in vitro (19). However, the occurrence of goiter in acromegaly was reported even when serum TSH levels were low, as in central hypothyroidism (CH), thus suggesting that increased GH/IGF1 levels per se may lead to thyroid growth (11,14).…”

Section: Introductionmentioning

confidence: 99%

Effects of GH replacement therapy on thyroid volume and nodule development in GH deficient adults: a retrospective cohort study

Curtò

Giovinazzo

Alibrandi

et al. 2015

European Journal of Endocrinology

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Objective: Despite the well-known effects of GH/IGF1 signaling on the thyroid, few data are available on the risk of developing nodular goiter in hypopituitary subjects during GH replacement therapy (GHRT). We aimed to define the effects of GH therapy on thyroid volume (TV) and nodular growth. Design: The records of 96 subjects (47 males and 49 females, median age 48 years) with GH deficit (GHD) were investigated. Seventy also had central hypothyroidism (CH). At the time of our retrospective evaluation, median treatment duration was 5 years. Results: Pre-treatment TV was smaller in GHD patients than in healthy subjects (PZ0.030). During GH treatment, TV significantly increased (PZ0.016 for the entire group and PZ0.014 in euthyroid GHD patients). Before starting GH therapy, 17 patients harbored thyroid nodules. During GH therapy, nodule size increased slightly in seven patients, and new thyroid nodules occurred in nine patients. Among the 79 patients without pre-existing thyroid nodules, 17 developed one or more nodules. There was no difference in the prevalence of CH in GHD patients with or without thyroid nodules (PZ0.915; PZ0.841, when patients with pre-therapy nodular goiter were excluded), the main predictor for nodule development being serum IGF1 (PZ0.038). Conclusions: GHRT is associated with TV's increase in GHD patients. Thyroid nodules developed in 27% of patients, mainly in relation to pre-therapy IGF1 levels, independently of normal or impaired TSH stimulation.

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Goiter and Impairment of Thyroid Function in Acromegalic Patients: Basal Evaluation and Follow-Up

Cited by 33 publications

References 9 publications

The Role of Insulin-Like Growth Factor 1 in the Development of Benign and Malignant Thyroid Nodules

The Role of Insulin-Like Growth Factor 1 in the Development of Benign and Malignant Thyroid Nodules

Acromegalia e doença tiroideana: prevalência de câncer de tireóide

Effects of GH replacement therapy on thyroid volume and nodule development in GH deficient adults: a retrospective cohort study

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