2022
DOI: 10.1128/spectrum.00459-22
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Abstract: SARS-CoV-2 or COVID-19’s first case was discovered in December 2019 in Wuhan, China, and by March 2020 it was declared a pandemic by the WHO. It has been shown that various underlying conditions can increase the chance of having severe COVID-19.

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Cited by 14 publications
(24 citation statements)
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“…However, we found that the IS4 "NSPR" created a pat7 NLS "PRRARSV" in the S protein, which was unique to SARS-CoV-2. We first reported that the S protein translocated into the nucleus in the SARS-CoV-2-infected airway epithelium, which is an appropriate lung model for studying respiratory virus infection in vitro [2,43]. Our results confirmed that the SARS-CoV-2 S protein was a unique addition to the list of viral proteins that possess NLSs and consequently translocate into the nucleus of infected cells [17,30,31,44].…”
Section: Discussionsupporting
confidence: 72%
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“…However, we found that the IS4 "NSPR" created a pat7 NLS "PRRARSV" in the S protein, which was unique to SARS-CoV-2. We first reported that the S protein translocated into the nucleus in the SARS-CoV-2-infected airway epithelium, which is an appropriate lung model for studying respiratory virus infection in vitro [2,43]. Our results confirmed that the SARS-CoV-2 S protein was a unique addition to the list of viral proteins that possess NLSs and consequently translocate into the nucleus of infected cells [17,30,31,44].…”
Section: Discussionsupporting
confidence: 72%
“…In this study, we used cells from five donors: nonsmoker healthy adults (donors #1 and #2) and adult with chronic obstructive pulmonary disease (COPD) (donor #3). The protocols for subculturing primary NHBE cells were published previously [2, 43, 50]. SARS-CoV-2 (USA/WA-CDC-WA1/2020 isolate, GenBank accession no.…”
Section: Methodsmentioning
confidence: 99%
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