Goblet cell carcinoid of the appendix

Pahlavan, Payam S.; Kanthan, Rani

doi:10.1186/1477-7819-3-36

Cited by 134 publications

(83 citation statements)

References 53 publications

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“…Our series is representative of the appendiceal GCC population, with similar baseline characteristics (age, gender distribution, symptoms at presentation, metastatic sites of spread) as previously described by other researches [2,4,5,6,7,8,35,36,42]. …”

Section: Discussionmentioning

confidence: 68%

“…The most common site of metastatic spread is to the peritoneum, via trans-coelomic spread, which is most frequently seen with spread to the ovaries (Krukenberg metastases) as reported in multiple case reports [9,16]; hence the rationale for performing bilateral oophorectomy as a prophylactic approach in women diagnosed with GCC by some centres [4,7]. …”

Section: Introductionmentioning

confidence: 99%

“…The median age at diagnosis was 58.9 years, with a similar distribution between genders [4]. Five-year disease-specific survival varies from 58 to 81% depending on the series [5,6,7].…”

Section: Introductionmentioning

confidence: 99%

“…One of the hypotheses for this phenomenon is the characteristic submucosal growth pattern, which increases the rate of distant metastases (mainly peritoneum) even with a low rate of lymph node spread. Moreover, the submucosal spread pattern avoids the development of an appendiceal mass, delaying the diagnosis [4]. …”

Section: Introductionmentioning

confidence: 99%

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Appendiceal Goblet Cell Carcinoids: Management Considerations from a Reference Peritoneal Tumour Service Centre and ENETS Centre of Excellence

Lamarca¹,

Nonaka²,

Escola³

et al. 2015

Neuroendocrinology

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Background: Appendix goblet cell carcinoids are known to share histological features of adenocarcinoma and neuroendocrine tumours. Due to their low incidence, quality evidence is lacking for the management of these patients. Methods: We performed a single-centre retrospective study of patients with a confirmed diagnosis of appendiceal goblet cell carcinoid (GCC; 1996-2014). Patients were divided into curative intent (CI) and palliative intent (PI) cohorts. Our primary end point was overall survival (OS). Results: Seventy-four patients were eligible; 76% were treated with CI [surgery only (36%), cytoreductive surgery (CRS) and hyperthermic intra-peritoneal chemotherapy (HIPEC; 36%), adjuvant chemotherapy (20%) and a combination of CRS and HIPEC followed by adjuvant chemotherapy (9%)], and 23% had advanced-stage disease amenable to palliative treatment (chemotherapy or supportive care) only. Completion right hemicolectomy, performed in 64% of the CI cohort, did not impact on the relapse rate or disease-free survival. FOLFOX chemotherapy was used in both the adjuvant and palliative settings; safety was as expected, and we observed a high rate (60%) of disease control in the palliative cohort. The estimated median OS (all patients), disease-free survival (CI patients) and progression-free survival (PI patients) were 52.1 (95% CI 29.4-90.3), 75.9 (26.6-not reached) and 5.3 (0.6-5.7) months, respectively. Age and stage were independent factors associated with OS in the multivariable analysis. Tang classification showed a trend for impact on OS. No benefit from specific adjuvant approach was identified; however, selection bias for treatment approach was observed. Conclusion: Prospective trials are needed to define optimal approaches in GCC. All GCC patients should be managed by specialized centres due to their esoteric behaviour; we provide management considerations based on our experience and conclusions.

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Section: Discussionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

“…The median age at diagnosis was 58.9 years, with a similar distribution between genders [4]. Five-year disease-specific survival varies from 58 to 81% depending on the series [5,6,7].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Appendiceal Goblet Cell Carcinoids: Management Considerations from a Reference Peritoneal Tumour Service Centre and ENETS Centre of Excellence

Lamarca¹,

Nonaka²,

Escola³

et al. 2015

Neuroendocrinology

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“…In cases with obvious spread of the disease, 5-Fu based chemotherapy regimens commonly used for colorectal cancer are advised [9]. Adjuvant therapy with 5-FU and leucoverin is not effective [10].…”

Section: /9mentioning

confidence: 99%

Goblet Cell Carcinoid Tumors of the Appendix: A Report of Two Cases, Review of a Rare Clinical Entity, and Guidelines for Treatment

Álvarez-Laso¹,

Azcano²,

Carrion³

et al. 2017

OALib

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Goblet cell carcinoid tumor is a rare clinical entity which is usually diagnosed either as acute appendicitis or advanced cancer. Its main characteristic is that the histological findings are between those of adenocarcinoma and typical carcinoid tumor of the appendix. Goblet cell carcinoid tumors appear almost exclusively in the appendix, and prognosis depends mainly on the stage and the subtype of the histological classification. We report three cases of goblet cell carcinoid tumor in the appendix with different clinical presentation and evolution: a 60-year-old male admitted to the emergency room with acute abdominal pain, diagnosed with acute appendicitis and treated with laparoscopic appendectomy; a 65-year-old male undergoing right hemicolectomy to remove a cecal adenoma, with a goblet cell carcinoid tumor found incidentally in the surgical specimen; and a 77-year-old male with acute appendicitis. We discuss the main pathological and clinical findings, and propose a set of guidelines for clinical practice.

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Analysis of 900 Appendiceal Carcinoid Tumors for a Proposed Predictive Staging System

Landry

Woodall²,

Scoggins³

et al. 2008

Arch Surg

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Goblet cell carcinoid of the appendix

Cited by 134 publications

References 53 publications

Appendiceal Goblet Cell Carcinoids: Management Considerations from a Reference Peritoneal Tumour Service Centre and ENETS Centre of Excellence

Appendiceal Goblet Cell Carcinoids: Management Considerations from a Reference Peritoneal Tumour Service Centre and ENETS Centre of Excellence

Goblet Cell Carcinoid Tumors of the Appendix: A Report of Two Cases, Review of a Rare Clinical Entity, and Guidelines for Treatment

Analysis of 900 Appendiceal Carcinoid Tumors for a Proposed Predictive Staging System

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