Goblet cell carcinoid of the appendix

Butler, John; Houshiar, Amir M.; Lin, Fritz; Wilson, Samuel E.

doi:10.1016/s0002-9610(05)80145-x

Cited by 108 publications

(92 citation statements)

References 8 publications

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“…They can also be detected incidentally during surgery that is performed for other organ diseases. These tumors rarely compose a discrete mass; therefore, they can be diagnosed only by postoperative histological analysis (6). Abnormal thickening of the appendix wall or deposition of mucinous material in its lumen are determinative signs for GCC (16).…”

Section: Discussionmentioning

confidence: 99%

“…Conversely, some authors suggest the necessity of right hemicolectomy because of the unpredictable behavior of GCC (9). While appendectomy is adequate for most patients, more radical approaches may be required in cases that present more complicated profiles, such as diffuse appendix involvement, tumor size greater than 2 cm, cellular undifferentiation, increased mitotic activity, presence of cecal wall involvement, or lymph node metastasis (3,6). Due to the high risk of metastasis to the ovaries in female cases, bilateral oophorectomy is recommended in addition to right hemicolectomy (19).…”

Section: Discussionmentioning

confidence: 99%

“…Goblet cell carcinoid tumors are located between carcinoid tumors and well-differentiated adenocarcinomas in terms of prognosis (6). The most important prognostic factor is the stage of the tumor (22).…”

Section: Discussionmentioning

confidence: 99%

“…The most important prognostic factor is the stage of the tumor (22). However, discussion regarding tumor size is controversial because tumors do not always form a significant mass (6). Metastasis to the ovaries and expansion into the abdominal cavity influence the prognosis very negatively.…”

Section: Discussionmentioning

confidence: 99%

“…GCC constitutes less than 5% of primary appendix tumors, and the mean age for GCC was determined to be 58.9 years (4,5). Because its behavior is more aggressive than that of the other standard carcinoid tumors, more extensive surgical approaches may be required (6). A five-year survey revealed a survival rate of 60%-84% (7).…”

Section: Introductionmentioning

confidence: 99%

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Goblet cell carcinoid of the appendix accompanied by adenomatous polyp with high-grade dysplasia at the cecum

et al. 2018

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Goblet cell carcinoid tumor of the appendix is an uncommon neoplasia that shares the histological attributes of both adenocarcinoma and carcinoid tumors. Its prognosis has a more aggressive course than the other known carcinoid tumors. Clinical diagnosis of goblet cell carcinoid is seldom made preoperatively. The most common clinical presentation of goblet cell carcinoid tumor is acute appendicitis. In this study, we report a patient on whom right hemicolectomy was performed because of a cacal sessile polyp with high grade dysplasia; goblet cell carcinoid tumor of the appendix was revealed incidentally during microscopic evaluation of the appendectomy specimen. The patient healed uneventfully and no recurrence was observed after the 12-month follow-up period. Careful microscopic examination of the appendectomy specimen is key for the diagnosis of appendiceal tumors such as goblet cell carcinoid, especially in elderly patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Goblet cell carcinoid of the appendix accompanied by adenomatous polyp with high-grade dysplasia at the cecum

et al. 2018

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Is Right Hemicolectomy for 2.0-cm Appendiceal Carcinoids Justified?

Bamboat

Berger²

2006

Arch Surg

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We believe right hemicolectomy (RHC) is not necessary in patients with an appendiceal carcinoid greater than 2.0 cm. Design: A retrospective review of patients with a histologically confirmed appendiceal carcinoid from April 1, 1980, to February 28, 2005, and an analysis of the literature. Setting: Tertiary care referral center. Patients: Forty-eight patients (34 females and 14 males) with a histologically confirmed diagnosis of appendiceal carcinoid were included in the study. Appendiceal carcinoid was diagnosed incidentally in all 48 patients. Patient ages ranged from 11 to 86 years (mean age, 41 years). Postoperative follow-up and disease-free survival were confirmed in 33 patients via medical record review. Main Outcome Measures: We assessed the relationship between survival, tumor size, and the role of RHC vs appendectomy alone. Results: Four patients in our series underwent secondary RHC and lymph node dissection for tumors greater than 2.0 cm, and none had positive lymph nodes. Following review of the literature, we were unable to find any recent evidence ofdistantmetastasisfromcarcinoidsinpatientsalreadytreated by appendectomy. There seem to be no conclusive data to support the notion that RHC confers a survival benefit over appendectomy for carcinoids greater than 2.0 cm. Conclusion: Appendiceal carcinoids greater than 2.0 cm can be managed effectively with simple appendectomy, given their low malignant potential and slow growth, obviating the need for RHC in this group of patients without affecting overall survival.

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