Glyphosate affects persistence and tolerance but not antibiotic resistance

Ospino, Katia; Spira, Beny

doi:10.1186/s12866-023-02804-1

Cited by 2 publications

(1 citation statement)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Glyphosate co-selects for AR [122] and induces imipenem resistance in P. aeruginosa [123]; glyphosate and dicamba modify b the effects of antibiotics [93]; glyphosate, glufosinate, and dicamba promote conjugation [124], and increase prevalence of AR genes and their transfer [125]; glyphosate affects persistence and tolerance without affecting antibiotic MICs [126]. Dazomet (soil fumigant) increases the relative abundance of AR genes, incidence of mobile genetic elements, and conjugation [127].…”

Section: Antibiotics Increase Conjugation Frequencymentioning

confidence: 99%

Non-Canonical Aspects of Antibiotics and Antibiotic Resistance

Amábile-Cuevas,

Lund-Zaina

2024

Antibiotics

View full text Add to dashboard Cite

The understanding of antibiotic resistance, one of the major health threats of our time, is mostly based on dated and incomplete notions, especially in clinical contexts. The “canonical” mechanisms of action and pharmacodynamics of antibiotics, as well as the methods used to assess their activity upon bacteria, have not changed in decades; the same applies to the definition, acquisition, selective pressures, and drivers of resistance. As a consequence, the strategies to improve antibiotic usage and overcome resistance have ultimately failed. This review gathers most of the “non-canonical” notions on antibiotics and resistance: from the alternative mechanisms of action of antibiotics and the limitations of susceptibility testing to the wide variety of selective pressures, lateral gene transfer mechanisms, ubiquity, and societal factors maintaining resistance. Only by having a “big picture” view of the problem can adequate strategies to harness resistance be devised. These strategies must be global, addressing the many aspects that drive the increasing prevalence of resistant bacteria aside from the clinical use of antibiotics.

show abstract

Section: Antibiotics Increase Conjugation Frequencymentioning

confidence: 99%

Non-Canonical Aspects of Antibiotics and Antibiotic Resistance

Amábile-Cuevas,

Lund-Zaina

2024

Antibiotics

View full text Add to dashboard Cite

show abstract

RpoS role in antibiotic resistance, tolerance and persistence in E. coli natural isolates

Valencia,

de Moraes Gomes,

Ospino

et al. 2024

BMC Microbiol

View full text Add to dashboard Cite

Background The intrinsic concentration of RpoS, the second most abundant sigma factor, varies widely across the E. coli species. Bacterial isolates that express high levels of RpoS display high resistance to environmental stresses, such as temperature, pH and osmolarity shifts, but are less nutritional competent, making them less capable of utilising alternative nutrient sources. The role of RpoS in antibiotic resistance and persistence in standard laboratory domesticated strains has been examined in several studies, most demonstrating a positive role for RpoS. Results Using disk diffusion assays we examined bacterial resistance to 15 different antibiotics, including $$\upbeta$$ β -lactams (penicillins, monobactams, carbapenems and cephalosporins), aminoglycosides, quinolones and anti-folates, in a representative collection of 328 E. coli natural isolates displaying a continuum of different levels of RpoS. There was an overall trend that isolates with higher levels of RpoS were slightly more resistant to these antibiotics. In addition, the effect of RpoS on bacterial tolerance and persistence to 3 different antibiotics - ampicillin, ciprofloxacin and kanamycin was evaluated through time-kill curves. Again, there was a small beneficial effect of RpoS on tolerance and persistence to these antibiotics, but this difference was not statistically significant. Finally, a K-12 strain expressing high levels of RpoS was compared with its isogenic RpoS-null counterpart, and no significant effect of RpoS was found. Conclusion Based on a representative collection of the species E. coli, RpoS was found to have a very small impact on antibiotic resistance, tolerance, or persistence.

show abstract

Glyphosate affects persistence and tolerance but not antibiotic resistance

Cited by 2 publications

References 63 publications

Non-Canonical Aspects of Antibiotics and Antibiotic Resistance

Non-Canonical Aspects of Antibiotics and Antibiotic Resistance

RpoS role in antibiotic resistance, tolerance and persistence in E. coli natural isolates

Contact Info

Product

Resources

About