2014
DOI: 10.1038/bjc.2014.280
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Abstract: Background:Glyoxalase I (GI) is a cellular defence enzyme involved in the detoxification of methylglyoxal (MG), a cytotoxic byproduct of glycolysis, and MG-derived advanced glycation end products (AGEs). Argpyrimidine (AP), one of the major AGEs coming from MG modifications of proteins arginines, is a pro-apoptotic agent. Radiotherapy is an important modality widely used in cancer treatment. Exposure of cells to ionising radiation (IR) results in a number of complex biological responses, including apoptosis. T… Show more

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Cited by 55 publications
(55 citation statements)
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“…Moreover, Hiroya et al demonstrated that knockdown of GLOI induced apoptosis in cancer cells [28]. Antognelli et al reported that GLOI inhibition induced apoptosis in irradiated MCF-7 cells [29]. All of these findings are consistent with our results.…”
Section: Discussionsupporting
confidence: 93%
“…Moreover, Hiroya et al demonstrated that knockdown of GLOI induced apoptosis in cancer cells [28]. Antognelli et al reported that GLOI inhibition induced apoptosis in irradiated MCF-7 cells [29]. All of these findings are consistent with our results.…”
Section: Discussionsupporting
confidence: 93%
“…Total protein extraction was performed by lysing the cells with radioimmunoprecipitation assay (RIPA) lysis buffer. 25 The nuclear extracts were prepared with the FractionPREP Cell Fractionation kit (Biovision, Florence, Italy). Protein concentration was determined with the BCA kit, using bovine serum albumin as a standard.…”
Section: Cell Lysate Preparationmentioning
confidence: 99%
“…As high expression of Glo1 supports robust tumour growth then poor treatment outcomes may not be limited to chemotherapy but to radiotherapy and surgical interventions. In radiotherapy dicarbonyl stress is induced by GSH depletion and decreased in situ activity of Glo1 contributes to the tumour cell kill [46]. Increased Glo1 expression was also associated with tissue invasiveness, lymph node metastasis and pathological stage -for example, in gastric cancer [47] -making the effectiveness and success of surgical therapy more challenging.…”
Section: Association Of Increased Glo1 Expression With Robust Tumour mentioning
confidence: 99%