Glycosaminoglycans and Proteoglycans in Palmar Fascia of Patients With Dupuytren

Nascimento, Priscilla Carneiro Hirai; Kobayashi, Elsa Yoko; Lenzi, L; Santos, João Baptista Gomes dos; Nader, Helena B.; Faloppa, Flávio

doi:10.1590/1413-785220162402154342

Cited by 2 publications

(2 citation statements)

References 16 publications

(22 reference statements)

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“…This contributes to the thickening of the palmar fascia seen in the disease. Dermatan sulfate has been found to be two fold greater in tissue affecting by Dupuytren's and is known to affect collagen organization, deposition rate, and maintenance of fibers [43]. The same study also demonstrated an increased heparin sulfate composition in patients with Dupuytren's, which has been shown to play a role in cell recognition, adhesion, growth control, and angiogenesis.…”

Section: Biochemical Changesmentioning

confidence: 78%

Dupuytren’s Disease

Lubahn¹

2018

Essentials of Hand Surgery

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Dupuytren's disease is a fibroproliferative disease affecting the palmar fascia of the hand and leading to flexion contractures of the digits. It was first described in Northern European populations and derived its namesake from Dr. Baron Dupuytren, a French surgeon, who was one of the first to lecture on the disease. The etiology of Dupuytren's disease is unclear but is likely influenced by both genetic and environmental factors. Older individuals and men are most at risk of developing the disease. Dupuytren's disease is a clinical diagnosis and patients often present with gradually worsening flexion contractures. Mild disease is usually observed, but surgical treatment is preferred for debilitating contractures. A variety of surgical techniques have been described involving either incising or excising diseased fascia. Overall, surgery is effective in correcting contractures and improving function, but despite successful treatment some patients still experience recurrence. More recently, collagenase injections and percutaneous procedures have been utilized to treat Dupuytren's disease and have yielded promising results in select patients.

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“…Collagen lattices are optimal for assessing the evolution of isolated cellularity and the effects of factors that are soluble in them [9], but they do not comprise a "real" comparative field for DC. Alterations in the ECM of DC have been observed, for example, in dermatan sulfate [10] or in the increase of biglycan deposits [11]. Spatial reorganization of the ECM is a crucial turning point for fibroblast activity [12].…”

Section: Problems With DC Researchmentioning

confidence: 99%

Prevention of Recurrences in Dupuytren’s Contracture: Are We in the Right Side?

Sanjuán-Cerveró

2019

SN Compr. Clin. Med.

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Dupuytren contracture is a fibroproliferative disorder affecting the palm of the hand causing a sustained flexion of the fingers due to fibrous cord contracture. Collagenase clostridium histolyticum, as pharmacological treatment, achieves the selective degradation of a portion of the cord, thus enabling the affected finger's functionality. Our hypothesis is based on a literary review looking for associations based on collagenase for the treatment of the Dupuytren's disease. Current treatment options for Dupuytren's are symptomatic and aim at removing part of the affected tissue to restore hand functionality. Recurrence remains the greatest challenge for achieving long-term successful treatment. The association of a hydrogel with the collagenase increases the action time of the latter. The association to a collagenase-hydrogel complex with a third drug (anti-TGFß) acting at the unstructured extracellular matrix in the proliferative phase of the response of wound healing that takes place after the administration of collagenase for direct action on the transformation of fibroblast into myofibroblast, thus resembling as far as possible the actions drugs have on cell cultures. However, in Dupuytren's contracture, the breakage and degradation of the cord that occur with current treatment make this increase in local action time unnecessary. Combining actual treatment options in Dupuytren's disease with a hydrogel acting as a vehicle can provide an alternative to destroy the extracellular matrix and act directly against the myofibroblast.

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Glycosaminoglycans and Proteoglycans in Palmar Fascia of Patients With Dupuytren

Cited by 2 publications

References 16 publications

Dupuytren’s Disease

Prevention of Recurrences in Dupuytren’s Contracture: Are We in the Right Side?

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