Glycolytic metabolite phosphoenolpyruvate protects host from viral infection through promoting AATK expression
Lu Zhao,
Renjie Song,
Yang Liu
Abstract:Viral infections can result in metabolism rewiring of host cells, which in turn affects the viral lifecycle. Phosphoenolpyruvate (PEP), a metabolic intermediate in the glycolytic pathway, plays important roles in several biological processes including anti‐tumor T cell immunity. However, whether PEP might participate in modulating viral infection remains largely unknown. Here, we demonstrate that PEP generally inhibits viral replication via upregulation of AATK expression. Targeted metabolomic analyses shown t… Show more
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