Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion

Schmieg, John; Yang, Guangli; Franck, Richard W.; Rooijen, Nico van; Tsuji, Moriya

doi:10.1073/pnas.0408288102

Cited by 113 publications

(91 citation statements)

References 43 publications

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“…Viruses cDC requirement for LCMV, 35 HSV-1, 36 VSV, 37 influenza, 38 CTL response cDC independence of anti-VSV B and CD4 T-cell response 36,39 Bacteria cDC requirement for anti-Listeria CTL response 11,40 cDC requirement for efficient Mycobacterium tuberculosis CD4 T-cell response 41 cDC requirement for anti-Salmonella response 42,43 cDC independence of UPEC clearance 44 Parasites cDC requirement for anti-Plasmodium 11 and anti-Leishmania response 45,46 Prions cDC requirement for intestinal Scrapie agent neuroinvasion 47 Miscellaneous Tolerance cDC role in Ig complex-mediated priming and tolerization 48,49 cDC independence of peripheral CD4 T-cell tolerization 50 NK responses cDC requirement for NK cell activation by IL-15 trans-presentation 25 NKT responses cDC requirement for glycolipid presentation 51,52 CTL responses cDC requirement for efficient CTL memory generation 27 Respiratory tract cDC requirement for asthma and experimental allergic rhinitis 18,53 Tumor studies cDC requirement for antitumor immunity 52 DC functions by conditional cell ablation A Sapoznikov and S Jung subpopulations and generally provided by non-hematopoietic cells, including stromal and follicular dendritic cells; 58 and (2) the chemokine macrophage migration inhibitory factor (MIF) that controls mature B-and tumor cell survival through triggering of the CD74-CD44 receptor complex. [59][60][61] 70 on pDC.…”

Section: Pathogen Defensementioning

confidence: 99%

Probing in vivo dendritic cell functions by conditional cell ablation

Sapoznikov

2008

Immunol Cell Biol

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Dendritic cells (DCs) play a central role in T-cell activation and the control of the inherent autoreactivity of the T-cell compartment. Pleiotropic DC functions are likely associated with discrete DC subsets. However, the latter remain largely defined by phenotype and unique anatomic location, rather than function. The investigation of DC involvement in complex phenomena that rely on multicellular interactions, such as immuno-stimulation and tolerization calls for an assessment of DC functions within physiological context. Given the highly dynamic DC compartment, the method of choice to study in vivo DC functions is their conditional ablation in the intact organism. Here, we summarize the recent progress in this field highlighting pitfalls and prospects of the approach.

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Section: Pathogen Defensementioning

confidence: 99%

Probing in vivo dendritic cell functions by conditional cell ablation

Sapoznikov

2008

Immunol Cell Biol

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“…In their studies, they used a C-glycosidic form of ␣-GalCer in analyses of the adjuvant properties of ␣-GalCer. It was found that the C-glycoside induced more of a Th1 (i.e., IFN-␥) response, was longer lasting, and was actually a better adjuvant than the parental compound itself in murine models of malaria and metastatic melanoma (53)(54)(55)(56)(57). Furthermore, ␣-GalCer administration has been shown to be mostly protective activity against viruses (58 -61), bacteria (62)(63)(64)(65)(66)(67), and other pathogens (68,69).…”

Section: ␣-Galactosylceramide (␣-Galcer) and ␣-Galcer Analogsmentioning

confidence: 99%

CD1d Ligands: The Good, the Bad, and the Ugly

Brutkiewicz

2006

The Journal of Immunology

160

132

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The MHC class I-like CD1d glycoprotein is a member of the CD1 family of Ag-presenting molecules and is responsible for the selection of NKT cells. A number of ligands that can be presented by CD1d to NKT or other CD1d-restricted T cells have been identified. These include glycolipids from a marine sponge, bacterial glycolipids, normal endogenous glycolipids, tumor-derived phospholipids and glycolipids, and nonlipidic molecules. The presentation of many of these molecules can have immunopotentiating effects, such as serving as an adjuvant against malaria or resulting in a more rapid clearance of certain virus infections. They can also be protective in autoimmune diseases or cancer or can be deleterious. This review will highlight these ligands in a discussion of their potential use against (and role in the pathogenesis of) these diseases.

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“…Although special roles for tissue-specific APCs in activating iNKT cells have recently been described, in theory any CD1d ϩ cell is capable of eliciting some type of iNKT cell response (27). To address the possibility that the observed Lck-CD1d Tg ϩ iNKT cell phenotype is due to the selective absence of CD1d on some cell types, we repeated the in vivo ␣-GalCer stimulation assays in both Lck-CD1d TgCD1°and Lck-CD1d TgCD1 ϩ mice, the latter of which maintain the endogenous CD1d expression program.…”

Section: Inefficient Ag Presentation Cannot Account For the Hyporespomentioning

confidence: 99%

“…The mechanism(s) regulating iNKT function is unclear. Functional differences in iNKT cells in various disease models may be mediated by the quality of the stimulating signal, which may be attributable to differential TCR/ligand interactions (25,26) and selective presentation of Ag by different CD1d-expressing cell types (27). Activation of phenotypically and/or anatomically distinct subsets of iNKT cells may also account for differences in iNKT function.…”

mentioning

confidence: 99%

A Cell-Type Specific CD1d Expression Program Modulates Invariant NKT Cell Development and Function

Zimmer

Colmone

Felio

et al. 2006

The Journal of Immunology

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Invariant NK T (iNKT) cells are a distinct subset of T cells that rapidly produce an array of immunoregulatory cytokines upon activation. Cytokines produced by iNKT cells subsequently transactivate other leukocytes and elicit their respective effector functions. In this way, iNKT cells play a central role in coordinating the development of immune responses in a variety of settings. However, the mechanisms governing the quality of the iNKT cell response elicited remain poorly defined. To address whether changes in the CD1d expression pattern could regulate iNKT cell function, we generated a transgenic (Tg) mouse model in which thymocytes and peripheral T cells express high levels of CD1d (Lck-CD1d Tg+ mice). The expression of CD1d by T cells was sufficient to rescue development of iNKT cells in mice deficient of endogenous CD1d. However, the relative proportions of iNKT cell subsets in Lck-CD1d Tg+ mice were distinctly different from those in wild-type mice, suggesting an altered developmental program. Additionally, iNKT cells were hyporesponsive to antigenic stimulation in vivo. Interestingly, Lck-CD1d Tg+ mice develop liver pathology in the absence of any exogenous manipulation. The results of these studies suggest that changes to the CD1d expression program modulate iNKT cell development and function.

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Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion

Cited by 113 publications

References 43 publications

Probing in vivo dendritic cell functions by conditional cell ablation

Probing in vivo dendritic cell functions by conditional cell ablation

CD1d Ligands: The Good, the Bad, and the Ugly

A Cell-Type Specific CD1d Expression Program Modulates Invariant NKT Cell Development and Function

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