Glycine stimulates striatal dopamine release in conscious rats

Yadid, Gal; Pacák, Karel; Golomb, Eliahu; Harvey−White, Judith; Lieberman, Daniel M.; Kopin, Irwin J.; Goldstein, David S.

doi:10.1111/j.1476-5381.1993.tb13770.x

Cited by 79 publications

(83 citation statements)

References 22 publications

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“…In the central nervous system, glycine and these receptors mediate inhibitory neurotransmission in the same manner as GABA and work simultaneous with GABA (Legendre 2001;Lopez et al 2001). Moreover, it was revealed that glycine injection increases dopamine concentration in the rat striatum interstitium (Yadid et al 1993). Thus, we examined whether theanine increased interstitial glycine concentration and whether glycine neurotransmission contributed to the increase in interstitial dopamine.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, some studies suggested that dopamine could modify glutamate neurotransmission. (Moghaddam et al 1990;Yadid et al 1993;Koga and Momiyama 2000). Because the chemical structure of theanine is similar to glutamic acid, some studies of theanine examined its relationship to glutamic acid function and metabolism (Sugiyama et al 2003;Kakuda et al 2002a;Tsuge et al 2003;Oda et al 1980); however, the glutamate receptor antagonist MK-801 did not affect the increase of dopamine concentration by theanine injection in the rat striatum (Yokogoshi et al 1998a).…”

Section: Discussionmentioning

confidence: 99%

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Theanine, γ-glutamylethylamide, a unique amino acid in tea leaves, modulates neurotransmitter concentrations in the brain striatum interstitium in conscious rats

et al. 2008

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Theanine (c-glutamylethylamide) is one of the major amino acid components in green tea and can pass through the blood-brain barrier. Recent studies suggest that theanine affects the mammalian central nervous system; however, the detailed mechanism remains unclear. In this study, we demonstrated the effect of theanine on neurotransmission in the brain striatum by in vivo brain microdialysis. Theanine injection into the rat brain striatum did not increase the concentration of excitatory neurotransmitters in the perfusate. On the other hand, theanine injection increased the concentration of glycine in the perfusate. Because it has been reported that theanine promotes dopamine release in the rat striatum, we investigated the glycine and dopamine concentrations in the perfusate. Co-injection of glycine receptor antagonist, strychnine, reduced theanine-induced changes in dopamine. Moreover, AMPA receptor antagonist, which regulates glycine and GABA release from glia cells, inhibited these effects of theanine and this result was in agreement with the known inhibitory effect of theanine at AMPA receptors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Theanine, γ-glutamylethylamide, a unique amino acid in tea leaves, modulates neurotransmitter concentrations in the brain striatum interstitium in conscious rats

et al. 2008

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“…This serotoninergic hyperinnervation, often observed in animal models of PD (Zhou et al, 1991;Gaspar et al, 1993;Yamazoe et al, 2001), may be compensatory. Indeed, 5-HT may promote DA release from the remaining dopaminergic fibers (Benloucif and Galloway, 1991;Yadid et al, 1994). Finally, the correlation between 5-HT concentration in the associative-limbic territory and recovery time strongly suggests a role for 5-HT in recovery.…”

Section: Relevance Of Repeated Microdialysis For Investigating Neurocmentioning

confidence: 99%

Behavioral Recovery in MPTP-Treated Monkeys: Neurochemical Mechanisms Studied by Intrastriatal Microdialysis

Boulet

Mounayar²,

Poupard³

et al. 2008

J. Neurosci.

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Parkinson's disease (PD) patients express motor symptoms only after 60 -80% striatal dopamine (DA) depletion. The presymptomatic phase of the disease may be sustained by biochemical modifications within the striatum. We used an appropriate specific 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) monkey model (Mounayar et al., 2007) to study the compensatory mechanisms operating in recovery from PD motor symptoms. We assessed the levels of DA and its metabolites (DOPAC, homovanillic acid), GABA, glutamate (Glu), serotonin (5-HT) and its metabolite (5HIAA) by repeated intracerebral microdialysis in awake animals before exposure to MPTP during full expression of the motor symptoms induced by MPTP and after recovery from these symptoms. Measurements were obtained from two functionally and anatomically different striatal areas: the associative-limbic territory and sensorimotor territory. Animals with motor symptoms displayed an extremely large decrease in levels of DA and its metabolites and an increase in Glu and GABA levels, as reported by other studies. However, we show here for the first time that serotonin levels increased in these animals. We found that increases in DA levels in the sensorimotor and/or associative-limbic territory and high levels of 5-HT and of its metabolite, 5HIAA, were associated with recovery from motor symptoms in this model. Determining whether similar changes in DA and 5-HT levels are involved in the compensatory mechanisms delaying the appearance of motor symptoms in the early stages of PD might make it possible to develop new treatment strategies for the disease.

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“…Many neurochemical studies demonstrate this relationship (Nurse et al 1988;Blandina et al 1988;Yi et al 1991;Jacocks and Cox 1992;Hallbus et al 1997;Benloucif and Galloway 1991;Parsons and Justice 1993;Yadid et al 1994;Yoshimoto et al 1996). The 5-HT-DA interaction question has been approached in an elegant and novel way by Broderick and Phelix (1997).…”

Section: -Ht-da Interactions In Reward and Motor Behavior 449mentioning

confidence: 99%

Serotonin-Dopamine Interactions in the Control of Conditioned Reinforcement and Motor Behavior

Sasaki‐Adams

Kelley

2001

Neuropsychopharmacology

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These studies addressed the question of serotonin (5-HT)-dopamine (DA) interactions with regard to reward-related behavior and motor activity in rats. The first experiment evaluated the effect of chronic treatment with fluoxetine (7 mg/kg/day), a serotonin-selective reuptake inhibitor, and buproprion (15 mg/kg/day), a dopamine reuptake inhibitor, on responding for conditioned reinforcement (CR). Chronic fluoxetine, but not buproprion, enhanced CR responding, and also potentiated cocaine-induced increases in CR responding. In the second experiment, animals received intra-accumbens infusions of either 1, 5, and 10 g) or DA (10, 20 g) The dopaminergic and serotonergic neurotransmitter systems are thought to play a critical role in the regulation of emotion and mood, and have been implicated in a spectrum of neuropsychiatric disorders. Psychotropic drugs affecting dopaminergic or serotonergic systems have been used to treat such disorders as depression, bipolar disorder, schizophrenia, eating disorders, obsessive compulsive disorder, and autism and have also been used to alleviate motor dysfunction associated with Tourette's syndrome, Parkinson's disease, and self-injurious behavior. Since both these transmitter systems appear to play such a critical role in mental functions, there has been a considerable amount of interest in their potential interactions. The nucleus accumbens, which has been implicated in reward and motivation, is one brain region where such an interaction may take place. There are high levels of dopamine (DA), dopamine receptors, serotonin (5-HT), and serotonin receptors in this forebrain region (Beal and Martin 1985;Bonaventure et al. 1997;Bouyer et al. 1984;Eberle-Wang et al. 1997;Joyce and Marshall 1987;Kilpatrick et al. 1987; Phelix and Broderick 1995;. The classical role of dopamine in the nucleus accumbens has been attributed to regulating motivation and reward-related behavior (Robbins and Everitt 1996;Schultz 1997;Wise and Rompré 1989). For example, drugs of abuse, such as cocaine and amphetamine, are believed to exert their euphoric effects primarily via activating the dopamine system (Di Chiara and Imperato 1988; Koob and Bloom 1988). In contrast to the substantial body of research on dopamine in the nucleus accumbens, there has been comparatively little attention given to the role of serotonin and serotonin-dopamine interactions in the nucleus accumbens.There are a number of reasons why further understanding of dopamine-serotonin interactions would be useful. Although depression undoubtedly involves a complex dysregulation of many transmitter and neuroendocrine systems, a majority of drugs used to treat depression affects the serotonin system. Serotoninselective re-uptake inhibitors (SSRIs) such as fluoxetine enhance synaptic levels of serotonin (5-HT), and are generally quite effective in ameliorating the symptoms of depression. Thus, one widely held hypothesis is that dysfunction in serotonergic neurons and their targets may underlie depressive symptomatology (van Praag et al. 1...

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Glycine stimulates striatal dopamine release in conscious rats

Cited by 79 publications

References 22 publications

Theanine, γ-glutamylethylamide, a unique amino acid in tea leaves, modulates neurotransmitter concentrations in the brain striatum interstitium in conscious rats

Theanine, γ-glutamylethylamide, a unique amino acid in tea leaves, modulates neurotransmitter concentrations in the brain striatum interstitium in conscious rats

Behavioral Recovery in MPTP-Treated Monkeys: Neurochemical Mechanisms Studied by Intrastriatal Microdialysis

Serotonin-Dopamine Interactions in the Control of Conditioned Reinforcement and Motor Behavior

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