Ariel Avila, Pía M. Vidal, T. Neil Dear, Robert J. Harvey, Jean-Michel Rigo, Laurent Nguyen
Abstract:SummaryGlycine receptors (GlyRs) are detected in the developing CNS before synaptogenesis, but their function remains elusive. This study demonstrates that functional GlyRs are expressed by embryonic cortical interneurons in vivo. Furthermore, genetic disruption of these receptors leads to interneuron migration defects. We discovered that extrasynaptic activation of GlyRs containing the α2 subunit in cortical interneurons by endogenous glycine activates voltage-gated calcium channels and promotes calcium influ…
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