Glycemic Control Rate of T2DM Outpatients in China: A Multi-Center Survey

Zou, Da-jin

doi:10.12659/msm.892246

Cited by 44 publications

(24 citation statements)

References 24 publications

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“…However, at present, glycemic control is less than ideal all over the world. A cross-sectional study of 9065 T2DM outpatients from 26 medical centers in China found that blood glucose levels were controlled in only 32.6% of patients [ 27 ],which was similar to the rate of 31.78% among 238,639 diabetes patients reported by Ji et al in 2013 [ 28 ]. The International Diabetes Mellitus Practice Study [ 29 ] included 11,799 patients from 17 countries in Eastern Europe, Africa, South America, and Latin America and found a blood glucose-control rate of only 25%.…”

Section: Discussionsupporting

confidence: 62%

Lower Extremity Peripheral Arterial Disease Is an Independent Predictor of Coronary Heart Disease and Stroke Risks in Patients with Type 2 Diabetes Mellitus in China

Pang

Han

et al. 2017

International Journal of Endocrinology

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We aimed to determine the relationship between lower extremity peripheral arterial disease (PAD), 10-year coronary heart disease (CHD), and stroke risks in patients with type 2 diabetes (T2DM) using the UKPDS risk engine. We enrolled 1178 hospitalized T2DM patients. The patients were divided into a lower extremity PAD group (ankle-brachial index ≤ 0.9 or >1.4; 88 patients, 7.5%) and a non-PAD group (ankle-brachial index > 0.9 and ≤1.4; 1090 patients, 92.5%). Age; duration of diabetes; systolic blood pressure; the hypertension rate; the use of hypertension drugs, ACEI /ARB, statins; CHD risk; fatal CHD risk; stroke risk; and fatal stroke risk were significantly higher in the PAD group than in the non-PAD group (P < 0.05 for all). Logistic stepwise regression analysis indicated that ABI was an independent predictor of 10-year CHD and stroke risks in T2DM patients. Compared with those in the T2DM non-PAD group, the odds ratios (ORs) for CHD and stroke risk were 3.6 (95% confidence interval (CI), 2.2–6.0; P < 0.001) and 6.9 (95% CI, 4.0–11.8; P < 0.001) in those with lower extremity PAD, respectively. In conclusion, lower extremity PAD increased coronary heart disease and stroke risks in T2DM.

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Section: Discussionsupporting

confidence: 62%

Lower Extremity Peripheral Arterial Disease Is an Independent Predictor of Coronary Heart Disease and Stroke Risks in Patients with Type 2 Diabetes Mellitus in China

Pang

Han

et al. 2017

International Journal of Endocrinology

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“…[ 23 , 25 , 26 ]. In another study that used age rather than duration of diabetes, greater age was an independent risk factor for poor glycemic control, which is consistent with our study [ 27 ]. Therefore, the age differences in our study may have arisen from the longer duration of diabetes.…”

Section: Discussionsupporting

confidence: 92%

Health inequalities in hypertension and diabetes management among the poor in urban areas: a population survey analysis in south Korea

et al. 2016

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BackgroundThis study investigated whether the prevalence, awareness, treatment, and control of hypertension and diabetes differed by residential areas. In addition, the rate of good hypertension or diabetes control was examined separately in men and women, and in urban and rural areas.MethodsThis study used Korea National Health and Nutrition Examination V (2010–2012) data, a nationwide cross-sectional survey of general South Korean population. Residential areas were categorized into urban and rural areas.To examine differences between the residential areas in terms of prevalence, awareness, treatment, and control of hypertension and diabetes we performed a multivariate logistic regression adjusting for age, body mass index, physical activity, alcohol use, smoking, marital status, monthly income, and educational level. To investigate control of hypertension or diabetes within each residential area, we performed a subgroup analysis in both urban and rural areas.ResultsThe prevalence of hypertension is higher among men in urban areas than among those in rural areas (OR = 0.80; 95 % CI = 0.67–0.96, reference group = urban areas). However, the subgroups did not differ in terms of diabetes prevalence, awareness, treatment, and control. Regardless of both sex and residential area, participants in good control of their hypertension and diabetes were younger. Inequality in good control of hypertension was observed in men who lived in urban (≤Elementary school, OR 0.74, 95 % CI 0.60–0.92) and rural areas (≤Elementary school, OR 0.67, 95 % CI 0.46–0.99). Inequality in health status was found in women who resided in urban areas (≤Elementary school, OR 0.53, 95 % CI 0.37–0.75). Good control of diabetes also showed inequalities in health status for both men (≤Elementary school, OR 0.61, 95 % CI 0.40–0.94; Middle/High school, OR 0.69, 95 % CI 0.49–0.96) and women in urban areas (≤1 million won, OR 0.56, 95 % CI 0.33–0.93) (Reference group = ‘≥College’ for education and ‘>3 million’ Korean won for income).ConclusionsAfter correction for individual socioeconomic status, differences by residential area were not observed. However, when the participants with good disease control were divided by region, inequality was confirmed in urban residents. Therefore, differentiated health policies to resolve individual and regional health inequalities are necessary.

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“…Diabetes mellitus, a chronic and systematic metabolic condition, has become a global health problem. The hyperglycemic condition is an important etiologic factor leading to numerous debilitating complications that also influence various cellular and organ functions [ 31 , 32 ]. In 1935, urological complications of diabetes were recognized, including DCP, which have a profound effect on the quality of life of diabetic patients [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Combination of Luteolin and Solifenacin Improves Urinary Dysfunction Induced by Diabetic Cystopathy in Rats

et al. 2018

Med Sci Monit

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BackgroundThe purpose of the present study was to assess the effect of luteolin and solifenacin on diabetic cystopathy (DCP) and to investigate the mechanism of action. A novel link between the overexpression of c-Kit in the bladder and voiding dysfunction was identified in rats with DCP.Material/MethodsA rat model of DCP was successfully established by intraperitoneal injection of streptozotocin and a diet high in glucose and lipids, and animals were treated with luteolin and solifenacin. The effect of luteolin and solifenacin on urinary dysfunction in DCP rats was investigated by assessing bladder pressure and performing a volume test. The protein levels of c-Kit, stem cell factor (SCF), p110, and phosphorylated p110 in the bladder were detected by Western blot analysis and immunohistochemical staining.ResultsIn DCP rats, the protein levels of c-Kit, SCF and phosphorylated p110 in the bladder were significantly increased. However, oral treatment of DCP rats with luteolin combined with solifenacin resulted in effective improvement of overactive bladder and reduced the protein expression of c-Kit, SCF, and phosphorylated p110. Moreover, the effect of luteolin combined with solifenacin on maximum voiding pressure and residual urine volume was improved compared to that of luteolin alone.ConclusionsLuteolin improved overactive bladder in DCP rats, which may be due to SCF/c-kit inhibition, as well as the downregulation of the phosphoinositide-3 kinase signaling pathway. Moreover, solifenacin enhanced the potential pharmacological effect of luteolin in the treatment of DCP.

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Glycemic Control Rate of T2DM Outpatients in China: A Multi-Center Survey

Cited by 44 publications

References 24 publications

Lower Extremity Peripheral Arterial Disease Is an Independent Predictor of Coronary Heart Disease and Stroke Risks in Patients with Type 2 Diabetes Mellitus in China

Lower Extremity Peripheral Arterial Disease Is an Independent Predictor of Coronary Heart Disease and Stroke Risks in Patients with Type 2 Diabetes Mellitus in China

Health inequalities in hypertension and diabetes management among the poor in urban areas: a population survey analysis in south Korea

Combination of Luteolin and Solifenacin Improves Urinary Dysfunction Induced by Diabetic Cystopathy in Rats

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