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Cited by 42 publications
(23 citation statements)
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References 28 publications
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“…In Goto-Kakizaki rats, a rodent model of nonobese type 2 diabetes, DJB improved glycemic control in as little as 1 week postoperatively, with no changes in body weight (62). Rapid weight-independent improvements in glycemia are also consistent with DJB in nonobese or mild obese type 2 diabetic humans (63)(64)(65)(66). These studies suggest that the rearrangement of the intestinal tract mediates the glucose-lowering effects of DJB.…”
Section: Jejunal Nutrient Sensingmentioning
confidence: 75%
“…In Goto-Kakizaki rats, a rodent model of nonobese type 2 diabetes, DJB improved glycemic control in as little as 1 week postoperatively, with no changes in body weight (62). Rapid weight-independent improvements in glycemia are also consistent with DJB in nonobese or mild obese type 2 diabetic humans (63)(64)(65)(66). These studies suggest that the rearrangement of the intestinal tract mediates the glucose-lowering effects of DJB.…”
Section: Jejunal Nutrient Sensingmentioning
confidence: 75%
“…This effect is achieved through a weight lossindependent mechanism. This phenomenon is supported by the absence of significant weight loss but also by other factors, such as the lack of improvement in insulin resistance [14] and the moderate increase in serum C-peptide that occurs a few months after the operation [13]. However, the positive impact that RYGB has on T2D has been repeatedly demonstrated in clinical studies over the last 20 years.…”
Section: Mechanismsmentioning
confidence: 93%
“…The GJB has been clinically tested, mostly in small studies of low-BMI patients, with a relatively short follow-up. The majority of these studies have shown significant improvement in patient glycemic status [12][13][14]. This effect is achieved through a weight lossindependent mechanism.…”
Section: Mechanismsmentioning
confidence: 99%
“…Gender, duration of T2DM, previous use of insulin, and preoperative HOMA-IR and C-peptide levels were not significant predictive factors for success or nonsuccess. The only factor that signifi cantly predicted postoperative positive outcomes was a waist circumference reduction of at least 7 % compared with the baseline within the fi rst 6 months after surgery [ 13 ].…”
Section: "Classic" Duodenal-jejunal Bypassmentioning
confidence: 99%